PMID- 28864368 OWN - NLM STAT- MEDLINE DCOM- 20170908 LR - 20180222 IS - 1538-2990 (Electronic) IS - 0002-9629 (Linking) VI - 354 IP - 2 DP - 2017 Aug TI - Triglyceride to High-Density Lipoprotein Cholesterol Ratio and Cardiovascular Events in Diabetics With Coronary Artery Disease. PG - 117-124 LID - S0002-9629(17)30199-4 [pii] LID - 10.1016/j.amjms.2017.03.032 [doi] AB - BACKGROUND: It has been demonstrated that an elevated ratio of triglycerides (TG) to high-density lipoprotein cholesterol (HDL-C) is a risk factor of coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM) and is also found to be associated with cardiovascular events (CVEs) in the general population. However, its prognostic value in patients with T2DM along with CAD remains to be determined. MATERIALS AND METHODS: A total of 1,447 consecutive patients with T2DM with angiographic-proven stable CAD were enrolled in the present study and followed-up for an average of 20.3 months. The characteristics of all patients including fasting lipid profile were obtained at baseline and multivariate Cox proportional hazards models were constructed using log TG/HDL-C as a predictor variable. The relationships between CVEs and total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), non-HDL-C, TC/HDL-C, LDL-C/HDL-C and apolipoprotein B/ apolipoprotein AI (apoB/apoAI) were also explored. RESULTS: Compared with patients without CVEs, the ones who experienced CVEs had a higher TG/HDL-C ratio. Univariable regression revealed a significant association of log TG/HDL-C with CVEs (hazard ratio = 2.5, P = 0.015). After adjusting for multiple traditional risk factors of cardiovascular disease, the association was still found (hazard ratio = 2.47, P = 0.047). Moreover, results suggested that the ratios of non-HDL-C, TC/HDL-C, LDL-C/HDL-C and apoB/apoAI were not predictors for CVEs in T2DM. CONCLUSIONS: In our primary study, data suggested that elevated TG/HDL-C value might be a useful predictor for future CVEs in Chinese patients with T2DM with stable CAD. Further study is needed to confirm our findings. CI - Copyright (c) 2017 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved. FAU - Yang, Sheng-Hua AU - Yang SH AD - Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, FuWai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. FAU - Du, Ying AU - Du Y AD - Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, FuWai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. FAU - Li, Xiao-Lin AU - Li XL AD - Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, FuWai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. FAU - Zhang, Yan AU - Zhang Y AD - Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, FuWai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. FAU - Li, Sha AU - Li S AD - Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, FuWai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. FAU - Xu, Rui-Xia AU - Xu RX AD - Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, FuWai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. FAU - Zhu, Cheng-Gang AU - Zhu CG AD - Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, FuWai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. FAU - Guo, Yuan-Lin AU - Guo YL AD - Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, FuWai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. FAU - Wu, Na-Qiong AU - Wu NQ AD - Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, FuWai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. FAU - Qing, Ping AU - Qing P AD - Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, FuWai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. FAU - Gao, Ying AU - Gao Y AD - Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, FuWai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. FAU - Cui, Chuan-Jue AU - Cui CJ AD - Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, FuWai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. FAU - Dong, Qian AU - Dong Q AD - Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, FuWai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. FAU - Sun, Jing AU - Sun J AD - Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, FuWai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. FAU - Li, Jian-Jun AU - Li JJ AD - Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, FuWai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. Electronic address: lijianjun938@126.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20170406 PL - United States TA - Am J Med Sci JT - The American journal of the medical sciences JID - 0370506 RN - 0 (Cholesterol, HDL) RN - 0 (Triglycerides) SB - IM MH - Aged MH - China/epidemiology MH - Cholesterol, HDL/*blood MH - Coronary Artery Disease/*complications/*epidemiology MH - Diabetes Mellitus, Type 2/*complications/*epidemiology MH - Female MH - Humans MH - Male MH - Middle Aged MH - Proportional Hazards Models MH - Risk Factors MH - Triglycerides/*blood OTO - NOTNLM OT - Coronary artery disease OT - High-density lipoprotein cholesterol OT - Ratio OT - Triglyceride OT - Type 2 diabetes EDAT- 2017/09/03 06:00 MHDA- 2017/09/09 06:00 CRDT- 2017/09/03 06:00 PHST- 2016/11/09 00:00 [received] PHST- 2017/03/07 00:00 [revised] PHST- 2017/03/20 00:00 [accepted] PHST- 2017/09/03 06:00 [entrez] PHST- 2017/09/03 06:00 [pubmed] PHST- 2017/09/09 06:00 [medline] AID - S0002-9629(17)30199-4 [pii] AID - 10.1016/j.amjms.2017.03.032 [doi] PST - ppublish SO - Am J Med Sci. 2017 Aug;354(2):117-124. doi: 10.1016/j.amjms.2017.03.032. Epub 2017 Apr 6.