PMID- 28867022
OWN - NLM
STAT- MEDLINE
DCOM- 20180601
LR  - 20180601
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 246
DP  - 2017 Nov 1
TI  - Cardiac magnetic resonance evaluation of left ventricular functional, 
      morphological, and structural features in children and adolescents vs. young 
      adults with isolated left ventricular non-compaction.
PG  - 68-73
LID - S0167-5273(17)32345-8 [pii]
LID - 10.1016/j.ijcard.2017.05.100 [doi]
AB  - AIM: To investigate the left ventricular (LV) functional, morphological, and 
      structural features revealed by cardiac magnetic resonance (CMR) in 
      children/adolescents with isolated LV non-compaction (iLVNC), and to compare them 
      with those observed in young adults with iLVNC and healthy controls. METHODS: 56 
      subjects were included: 12 children/adolescents (mean age 15+/-3years, 75% male) 
      and 20 young adults (mean age 35+/-7years, 75% male) with first diagnosis of iLVNC, 
      12 healthy children/adolescents (mean age 15+/-3years, 75% male) and 12 healthy 
      young adults (mean age 34+/-8years, 75% male). CMR with late gadolinium enhancement 
      (LGE) imaging was performed to evaluate LV function, extent of LV trabeculation, 
      and presence/extent of LV LGE, a surrogate of myocardial fibrosis. 
      Tissue-tracking analysis was applied to assess LV global longitudinal (GLS), 
      circumferential (GCS) and radial (GRS) strain. RESULTS: The extent of LVNC and 
      the presence/extent of LV LGE in children/adolescents and young adults with iLVNC 
      were similar. Compared to healthy subjects, young adults with iLVNC had 
      significantly lower LVEF; conversely, no significant difference in this parameter 
      was observed between children/adolescents with iLVNC and healthy subjects. 
      However, compared to healthy subjects, LV strain parameters were lower in both 
      children/adolescents and young adults with iLVNC. CONCLUSIONS: Complete 
      phenotypic expression, subclinical impairment of myocardial deformation 
      properties, and cardiac injury occur early in iLVNC patients, being already 
      noticeable in the pediatric age group. The application of CMR myocardial 
      deformation imaging permits earlier detection of LV functional impairment in 
      children/adolescents with iLVNC, which would otherwise be missed with standard 
      CMR imaging.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Nucifora, Gaetano
AU  - Nucifora G
AD  - Department of Heart Health, South Australian Health & Medical Research Institute, 
      Adelaide, Australia; School of Medicine, Flinders University, Bedford Park, 
      Adelaide, Australia; Northwest Heart Centre, Wythenshawe Hospital, University 
      Hospital of South Manchester NHS Foundation Trust, Manchester, UK. Electronic 
      address: gaetano.nucifora@flinders.edu.au.
FAU - Sree Raman, Karthigesh
AU  - Sree Raman K
AD  - Department of Heart Health, South Australian Health & Medical Research Institute, 
      Adelaide, Australia; School of Medicine, Flinders University, Bedford Park, 
      Adelaide, Australia.
FAU - Muser, Daniele
AU  - Muser D
AD  - Division of Cardiology, University Hospital "Santa Maria della Misericordia", 
      Udine, Italy.
FAU - Shah, Ranjit
AU  - Shah R
AD  - Department of Heart Health, South Australian Health & Medical Research Institute, 
      Adelaide, Australia; School of Medicine, Flinders University, Bedford Park, 
      Adelaide, Australia.
FAU - Perry, Rebecca
AU  - Perry R
AD  - Department of Heart Health, South Australian Health & Medical Research Institute, 
      Adelaide, Australia; School of Medicine, Flinders University, Bedford Park, 
      Adelaide, Australia; Department of Cardiovascular Medicine, Flinders Medical 
      Centre, Bedford Park, Adelaide, Australia.
FAU - Awang Ramli, Kama A
AU  - Awang Ramli KA
AD  - Department of Heart Health, South Australian Health & Medical Research Institute, 
      Adelaide, Australia.
FAU - Selvanayagam, Joseph B
AU  - Selvanayagam JB
AD  - Department of Heart Health, South Australian Health & Medical Research Institute, 
      Adelaide, Australia; School of Medicine, Flinders University, Bedford Park, 
      Adelaide, Australia; Department of Cardiovascular Medicine, Flinders Medical 
      Centre, Bedford Park, Adelaide, Australia.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
SB  - IM
CIN - Int J Cardiol. 2018 Nov 15;271:402. PMID: 30223377
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Ventricles/*diagnostic imaging/physiopathology
MH  - Humans
MH  - Isolated Noncompaction of the Ventricular Myocardium/*diagnosis/physiopathology
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Myocardium/*pathology
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Ventricular Function, Left/*physiology
MH  - Young Adult
OTO - NOTNLM
OT  - Cardiac magnetic resonance
OT  - Isolated left ventricular non-compaction
OT  - Late gadolinium enhancement
OT  - Myocardial fibrosis
OT  - Strain
OT  - Tissue-tracking
EDAT- 2017/09/05 06:00
MHDA- 2018/06/02 06:00
CRDT- 2017/09/05 06:00
PHST- 2017/04/15 00:00 [received]
PHST- 2017/05/21 00:00 [revised]
PHST- 2017/05/30 00:00 [accepted]
PHST- 2017/09/05 06:00 [entrez]
PHST- 2017/09/05 06:00 [pubmed]
PHST- 2018/06/02 06:00 [medline]
AID - S0167-5273(17)32345-8 [pii]
AID - 10.1016/j.ijcard.2017.05.100 [doi]
PST - ppublish
SO  - Int J Cardiol. 2017 Nov 1;246:68-73. doi: 10.1016/j.ijcard.2017.05.100.