PMID- 28867034
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20181211
IS  - 1769-664X (Electronic)
IS  - 0929-693X (Linking)
VI  - 24
IP  - 9S
DP  - 2017 Sep
TI  - [Neonatal arterial ischemic stroke: Which thrombotic biological risk factors to 
      investigate and which practical consequences?].
PG  - 9S28-9S34
LID - S0929-693X(17)30328-7 [pii]
LID - 10.1016/S0929-693X(17)30328-7 [doi]
AB  - All biological risk factors that have been previously identified to increase the 
      risk of thrombosis in adults, have also been studied in neonates with arterial 
      Ischemic Stroke (NAIS), but most studies were retrospective and included 
      relatively low numbers of affected children. We therefore could not suggest 
      recommendations with a strong level of evidence and only expert proposals 
      potentially useful for clinical practice will be presented in this text. Despite 
      these limitations, the extensive analysis of published data supported that factor 
      V Leiden (FVL) and increased levels of Lp(a) could be significant risk factors 
      for NAIS. Importantly, these 2 risk factors cannot be considered as having 
      provoked NAIS, and moreover, they do not influence the prognosis and the 
      immediate treatment. However, since the FVL may have an impact for the 
      prescription of a thromboprophylaxis when the neonate will become adult, to look 
      for its presence in affected patients may be justified. For clinical practice, 
      the following propositions can be applied: 1. Routine testing for thrombophilia 
      (AT, PC PS deficiency, FV Leiden or FII20210A) or for detecting other biological 
      risk factors such as antiphospholipid antibodies, high FVIII, homocystein or 
      Lp(a) levels, MTHFR thermolabile variant, should not be considered in neonates 
      with NAIS. 2. Testing for FV Leiden can be performed in case of documented family 
      history of venous thromboembolic disease. 3. Testing neonates for the presence of 
      antiphospholipid antibodies (APA) is mandatory in case of clinical events 
      suggesting antiphospholipid syndrome in the mother (vascular thrombosis, and/or 
      pregnancy morbidity). 4. Routine testing for thrombophilia is not proposed in 
      both parents in case of early death of the neonate, apart from APA in the mother.
CI  - (c) 2017 Elsevier Masson SAS. Tous droits reserves.
FAU - Perez, T
AU  - Perez T
AD  - Centre hospitalier regional universitaire, soins intensifs neonataux et 
      pediatriques, Hopital d'Enfants de Clocheville, 49 boulevard Beranger, Tours, 
      37044, France.
FAU - Valentin, J B
AU  - Valentin JB
AD  - Centre hospitalier regional universitaire, service d'hematologie-hemostase, 
      Hopital Trousseau, Avenue de la Republique, Tours, 37170, France.
FAU - Saliba, E
AU  - Saliba E
AD  - Centre hospitalier regional universitaire, soins intensifs neonataux et 
      pediatriques, Hopital d'Enfants de Clocheville, 49 boulevard Beranger, Tours, 
      37044, France.
FAU - Gruel, Y
AU  - Gruel Y
AD  - Centre hospitalier regional universitaire, service d'hematologie-hemostase, 
      Hopital Trousseau, Avenue de la Republique, Tours, 37170, France. Electronic 
      address: yves.gruel@univ-tours.fr.
LA  - fre
PT  - Journal Article
PT  - Review
TT  - Accident vasculaire cerebral ischemique du nouveau-ne : quels facteurs 
      biologiques de risque thrombotique rechercher et quelles consequences en pratique 
      ?
PL  - France
TA  - Arch Pediatr
JT  - Archives de pediatrie : organe officiel de la Societe francaise de pediatrie
JID - 9421356
SB  - IM
MH  - Brain Ischemia/diagnosis/*etiology
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Newborn, Diseases/diagnosis/etiology
MH  - Practice Guidelines as Topic
MH  - Risk Factors
MH  - Stroke/diagnosis/*etiology
MH  - Thrombosis/complications/*diagnosis
EDAT- 2017/09/05 06:00
MHDA- 2018/12/12 06:00
CRDT- 2017/09/05 06:00
PHST- 2017/09/05 06:00 [entrez]
PHST- 2017/09/05 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
AID - S0929-693X(17)30328-7 [pii]
AID - 10.1016/S0929-693X(17)30328-7 [doi]
PST - ppublish
SO  - Arch Pediatr. 2017 Sep;24(9S):9S28-9S34. doi: 10.1016/S0929-693X(17)30328-7.