PMID- 28867217
OWN - NLM
STAT- MEDLINE
DCOM- 20180731
LR  - 20180801
IS  - 1873-1708 (Electronic)
IS  - 0890-6238 (Linking)
VI  - 74
DP  - 2017 Dec
TI  - In utero and lactational exposure to metformin induces reproductive alterations 
      in male rat offspring.
PG  - 48-58
LID - S0890-6238(17)30178-8 [pii]
LID - 10.1016/j.reprotox.2017.08.023 [doi]
AB  - Metformin (MET) is prescribed for the treatment of type 2 diabetes mellitus and 
      gestational diabetes. Although MET crosses the placenta, it is considered safe 
      throughout gestation. However, it has been shown in humans that maternal exposure 
      to MET increases sex hormone binding globulin levels in newborns, and in rats it 
      decreases the testosterone concentration at gestational day (GD) 16.5. Therefore, 
      the present study evaluated if maternal exposure to MET could interfere with 
      reproductive parameters of male offspring. Wistar female rats were treated with 
      MET 293mg/kg/day, by gavage from GD0 to GD21 (METG) or GD0 until lactational day 
      (LD) 21 (METGL) and the control groups received water. Sexual behavior of male 
      offspring was affected in both MET groups. However, a decrease in the sperm count 
      was observed only in METGL group. These results suggest that MET exposure induced 
      alterations in reproductive parameters of male offspring in adulthood depending 
      on exposure time.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Forcato, Simone
AU  - Forcato S
AD  - Department of Physiological Sciences, Center of Biological Sciences, State 
      University of Londrina, Londrina, PR, Brazil.
FAU - Novi, Daniella Regina Barrionuevo da Silva
AU  - Novi DRBDS
AD  - Department of Physiological Sciences, Center of Biological Sciences, State 
      University of Londrina, Londrina, PR, Brazil.
FAU - Costa, Nathalia Orlandini
AU  - Costa NO
AD  - Department of Physiological Sciences, Center of Biological Sciences, State 
      University of Londrina, Londrina, PR, Brazil.
FAU - Borges, Lorena Ireno
AU  - Borges LI
AD  - Department of Physiological Sciences, Center of Biological Sciences, State 
      University of Londrina, Londrina, PR, Brazil.
FAU - Goes, Maria Luiza Marino de
AU  - Goes MLM
AD  - Department of Physiological Sciences, Center of Biological Sciences, State 
      University of Londrina, Londrina, PR, Brazil.
FAU - Ceravolo, Graziela Scalianti
AU  - Ceravolo GS
AD  - Department of Physiological Sciences, Center of Biological Sciences, State 
      University of Londrina, Londrina, PR, Brazil.
FAU - Gerardin, Daniela Cristina Ceccatto
AU  - Gerardin DCC
AD  - Department of Physiological Sciences, Center of Biological Sciences, State 
      University of Londrina, Londrina, PR, Brazil. Electronic address: 
      dcgerardin@uel.br.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170901
PL  - United States
TA  - Reprod Toxicol
JT  - Reproductive toxicology (Elmsford, N.Y.)
JID - 8803591
RN  - 0 (Hypoglycemic Agents)
RN  - 3XMK78S47O (Testosterone)
RN  - 9100L32L2N (Metformin)
SB  - IM
MH  - Animals
MH  - Body Weight/drug effects
MH  - Female
MH  - Fertility/drug effects
MH  - Genitalia, Male/drug effects
MH  - Hypoglycemic Agents/*toxicity
MH  - Lactation
MH  - Male
MH  - Maternal-Fetal Exchange
MH  - Metformin/*toxicity
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Rats, Wistar
MH  - Sexual Behavior, Animal/drug effects
MH  - Sexual Maturation/drug effects
MH  - Sperm Count
MH  - Sperm Motility/drug effects
MH  - Spermatozoa/drug effects/physiology
MH  - Testosterone/blood
OTO - NOTNLM
OT  - Antidiabetic drug
OT  - Maternal exposure
OT  - Sexual behavior
OT  - Sperm count
EDAT- 2017/09/05 06:00
MHDA- 2018/08/01 06:00
CRDT- 2017/09/05 06:00
PHST- 2017/04/06 00:00 [received]
PHST- 2017/08/28 00:00 [revised]
PHST- 2017/08/31 00:00 [accepted]
PHST- 2017/09/05 06:00 [pubmed]
PHST- 2018/08/01 06:00 [medline]
PHST- 2017/09/05 06:00 [entrez]
AID - S0890-6238(17)30178-8 [pii]
AID - 10.1016/j.reprotox.2017.08.023 [doi]
PST - ppublish
SO  - Reprod Toxicol. 2017 Dec;74:48-58. doi: 10.1016/j.reprotox.2017.08.023. Epub 2017 
      Sep 1.