PMID- 28867550
OWN - NLM
STAT- MEDLINE
DCOM- 20171003
LR  - 20231112
IS  - 1097-4199 (Electronic)
IS  - 0896-6273 (Print)
IS  - 0896-6273 (Linking)
VI  - 95
IP  - 6
DP  - 2017 Sep 13
TI  - Neurotransmitter Switching Regulated by miRNAs Controls Changes in Social 
      Preference.
PG  - 1319-1333.e5
LID - S0896-6273(17)30738-9 [pii]
LID - 10.1016/j.neuron.2017.08.023 [doi]
AB  - Changes in social preference of amphibian larvae result from sustained exposure 
      to kinship odorants. To understand the molecular and cellular mechanisms of this 
      neuroplasticity, we investigated the effects of olfactory system activation on 
      neurotransmitter (NT) expression in accessory olfactory bulb (AOB) interneurons 
      during development. We show that protracted exposure to kin or non-kin 
      odorants changes the number of dopamine (DA)- or gamma aminobutyric acid 
      (GABA)-expressing neurons, with corresponding changes in attraction/aversion 
      behavior. Changing the relative number of dopaminergic and GABAergic AOB 
      interneurons or locally introducing DA or GABA receptor antagonists alters 
      kinship preference. We then isolate AOB microRNAs (miRs) differentially regulated 
      across these conditions. Inhibition of miR-375 and miR-200b reveals that they 
      target Pax6 and Bcl11b to regulate the dopaminergic and GABAergic phenotypes. The 
      results illuminate the role of NT switching governing experience-dependent social 
      preference. VIDEO ABSTRACT.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Dulcis, Davide
AU  - Dulcis D
AD  - Neurobiology Section, Division of Biological Sciences and Center for Neural 
      Circuits and Behavior, Kavli Institute for Brain and Mind, University of 
      California San Diego, La Jolla, CA 92093-0357, USA; Department of Psychiatry, 
      School of Medicine, University of California San Diego, La Jolla, CA 92093-0603, 
      USA. Electronic address: ddulcis@ucsd.edu.
FAU - Lippi, Giordano
AU  - Lippi G
AD  - Neurobiology Section, Division of Biological Sciences and Center for Neural 
      Circuits and Behavior, Kavli Institute for Brain and Mind, University of 
      California San Diego, La Jolla, CA 92093-0357, USA.
FAU - Stark, Christiana J
AU  - Stark CJ
AD  - Neurobiology Section, Division of Biological Sciences and Center for Neural 
      Circuits and Behavior, Kavli Institute for Brain and Mind, University of 
      California San Diego, La Jolla, CA 92093-0357, USA; Department of Psychiatry, 
      School of Medicine, University of California San Diego, La Jolla, CA 92093-0603, 
      USA.
FAU - Do, Long H
AU  - Do LH
AD  - Department of Neuroscience, University of California San Diego, La Jolla, CA 
      92093-0649, USA.
FAU - Berg, Darwin K
AU  - Berg DK
AD  - Neurobiology Section, Division of Biological Sciences and Center for Neural 
      Circuits and Behavior, Kavli Institute for Brain and Mind, University of 
      California San Diego, La Jolla, CA 92093-0357, USA.
FAU - Spitzer, Nicholas C
AU  - Spitzer NC
AD  - Neurobiology Section, Division of Biological Sciences and Center for Neural 
      Circuits and Behavior, Kavli Institute for Brain and Mind, University of 
      California San Diego, La Jolla, CA 92093-0357, USA.
LA  - eng
GR  - R01 NS012601/NS/NINDS NIH HHS/United States
GR  - R01 NS015918/NS/NINDS NIH HHS/United States
GR  - R01 NS057690/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Video-Audio Media
DEP - 20170831
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
RN  - 0 (Bcl11b protein, Xenopus)
RN  - 0 (Dopamine Antagonists)
RN  - 0 (GABA Antagonists)
RN  - 0 (MicroRNAs)
RN  - 0 (Neurotransmitter Agents)
RN  - 0 (PAX6 Transcription Factor)
RN  - 0 (Pax6 protein, Xenopus)
RN  - 0 (Pheromones)
RN  - 0 (Transcription Factors)
RN  - 0 (Xenopus Proteins)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Choice Behavior/*physiology
MH  - Dopamine/*biosynthesis/physiology
MH  - Dopamine Antagonists/pharmacology
MH  - GABA Antagonists/pharmacology
MH  - Interneurons/physiology
MH  - MicroRNAs/antagonists & inhibitors/metabolism/*physiology
MH  - Neurons/metabolism/physiology
MH  - Neurotransmitter Agents/*biosynthesis/physiology
MH  - Olfactory Bulb/*metabolism
MH  - PAX6 Transcription Factor/physiology
MH  - Pheromones/physiology
MH  - Siblings
MH  - *Social Behavior
MH  - Transcription Factors/physiology
MH  - Xenopus Proteins/physiology
MH  - Xenopus laevis
MH  - gamma-Aminobutyric Acid/*biosynthesis/physiology
PMC - PMC5893310
MID - NIHMS954226
OTO - NOTNLM
OT  - GABA
OT  - Xenopus larvae
OT  - accessory olfactory bulb
OT  - dopamine
OT  - miR-200b
OT  - miR-375
OT  - microRNA
OT  - neurotransmitter switching
OT  - odorants
OT  - social preference
EDAT- 2017/09/05 06:00
MHDA- 2017/10/04 06:00
PMCR- 2018/04/10
CRDT- 2017/09/05 06:00
PHST- 2017/03/17 00:00 [received]
PHST- 2017/07/12 00:00 [revised]
PHST- 2017/08/11 00:00 [accepted]
PHST- 2017/09/05 06:00 [pubmed]
PHST- 2017/10/04 06:00 [medline]
PHST- 2017/09/05 06:00 [entrez]
PHST- 2018/04/10 00:00 [pmc-release]
AID - S0896-6273(17)30738-9 [pii]
AID - 10.1016/j.neuron.2017.08.023 [doi]
PST - ppublish
SO  - Neuron. 2017 Sep 13;95(6):1319-1333.e5. doi: 10.1016/j.neuron.2017.08.023. Epub 
      2017 Aug 31.