PMID- 28867569
OWN - NLM
STAT- MEDLINE
DCOM- 20180319
LR  - 20181202
IS  - 1525-5069 (Electronic)
IS  - 1525-5050 (Linking)
VI  - 75
DP  - 2017 Oct
TI  - Quality of life one year after epilepsy surgery.
PG  - 213-217
LID - S1525-5050(17)30470-5 [pii]
LID - 10.1016/j.yebeh.2017.08.014 [doi]
AB  - BACKGROUND: The aim of surgery for medically intractable epilepsy was to achieve 
      seizure freedom and improve overall quality of life (QOL) in patients. This 
      investigation looked at changes in QOL one year after epilepsy surgery and the 
      relationship of changes to mood, language, and seizure outcomes. METHOD: 
      Depressive symptoms, QOL, and naming were measured in 25 patients with temporal 
      lobe epilepsy before and one year after dominant temporal lobe resection. The 
      Quality of Life in Epilepsy-89 (QOLIE-89), Beck Depression Inventory II (BDI-II), 
      and Boston Naming Test (BNT) were used, respectively, and seizure outcome was 
      reported according to the Engel classifications. Minimum clinically important 
      differences (MCID) and reliable change indices (RCI) were used to assess the 
      proportion of patients who achieved meaningful improvement or worsening in the 
      respective areas of functioning, and the relationship between outcomes was 
      evaluated. Changes on the 17 individual items of the QOLIE-89 were also assessed. 
      RESULTS: Overall, there was a significant improvement in QOL, reduction in 
      depressive symptoms, and decline in naming one year after surgery. Positive 
      clinically important improvement in QOL was achieved in 76% of patients, 
      meaningful reduction of depressive symptoms was achieved in 20%, and clinically 
      important naming declines were observed in 48% of the cohort. Sixteen patients 
      were seizure-free one year after surgery, but there was no significant 
      correlation between changes in QOL and seizure outcome, depressive symptoms, or 
      naming. CONCLUSION: The results in the reported cohort of patients showed that 
      surgical treatment of temporal lobe epilepsy in the dominant hemisphere resulted 
      in clinically meaningful improvement in overall QOL and declines in naming but no 
      significant reduction of mood disturbance.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Ives-Deliperi, Victoria
AU  - Ives-Deliperi V
AD  - Department of Neurology, University of Cape Town, South Africa. Electronic 
      address: vives@mweb.co.za.
FAU - Butler, James Thomas
AU  - Butler JT
AD  - Department of Neurology, University of Cape Town, South Africa; Department of 
      Neurology, University of Stellenbosch, South Africa.
LA  - eng
PT  - Journal Article
DEP - 20170901
PL  - United States
TA  - Epilepsy Behav
JT  - Epilepsy & behavior : E&B
JID - 100892858
SB  - IM
MH  - Adult
MH  - Anomia/epidemiology
MH  - Depression/epidemiology
MH  - Epilepsy, Temporal Lobe/*psychology/*surgery
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Psychiatric Status Rating Scales
MH  - *Quality of Life
MH  - Temporal Lobe/surgery
MH  - Treatment Outcome
MH  - Young Adult
OTO - NOTNLM
OT  - Epilepsy
OT  - Epilepsy surgery
OT  - QOLIE-89
OT  - Temporal lobe epilepsy
EDAT- 2017/09/05 06:00
MHDA- 2018/03/20 06:00
CRDT- 2017/09/05 06:00
PHST- 2017/06/07 00:00 [received]
PHST- 2017/08/07 00:00 [revised]
PHST- 2017/08/07 00:00 [accepted]
PHST- 2017/09/05 06:00 [pubmed]
PHST- 2018/03/20 06:00 [medline]
PHST- 2017/09/05 06:00 [entrez]
AID - S1525-5050(17)30470-5 [pii]
AID - 10.1016/j.yebeh.2017.08.014 [doi]
PST - ppublish
SO  - Epilepsy Behav. 2017 Oct;75:213-217. doi: 10.1016/j.yebeh.2017.08.014. Epub 2017 
      Sep 1.