PMID- 28868944
OWN - NLM
STAT- MEDLINE
DCOM- 20190214
LR  - 20190215
IS  - 1476-4954 (Electronic)
IS  - 1476-4954 (Linking)
VI  - 32
IP  - 2
DP  - 2019 Jan
TI  - Prehypertension in early versus late pregnancy.
PG  - 188-192
LID - 10.1080/14767058.2017.1374363 [doi]
AB  - INTRODUCTION: Hypertensive disorders play a significant role in maternal 
      morbidity and mortality. Limited data on prehypertension (preHTN) in pregnancy 
      exist. We examine the risk of adverse outcomes in patients with preHTN in early 
      (<20 weeks) versus late pregnancy (>20 weeks). MATERIALS AND METHODS: 
      Retrospective cohort study of singleton gestations between August 2013 and June 
      2014. Patients were divided based on when they had the highest blood pressure in 
      pregnancy, as defined per the Joint National Committee 7 (JNC-7). Groups were 
      compared using chi(2), Fisher's exact, Student's t-test, and Mann-Whitney U test 
      with p < .05 used as significance. RESULTS: There were 125 control, 95 early 
      preHTN, 136 late preHTN, and 21 chronic hypertension (CHTN). Early preHTN had an 
      increased risk of pregnancy-related hypertension (PRH) (OR 12.26, p < .01) and 
      composite adverse outcomes (OR 2.32, p < .01). Late preHTN had an increased risk 
      for PRH (OR 4.39, p = .02) compared with normotensive and decreased risk for PRH 
      (OR 0.26, p = .02), and composite adverse outcomes (OR 0.379, p = .04) compared 
      with CHTN. Compared with late preHTN, early preHTN had more PRH (OR 2.85, 
      p < .01), and composite adverse outcomes (OR 1.68, p = .04). CONCLUSIONS: Early 
      prehypertension increases the risk of adverse obstetrical outcomes. Other than an 
      increased risk of PRH, patients with late prehypertension have outcomes similar 
      to normotensive women.
FAU - Rosner, Jonathan Y
AU  - Rosner JY
AUID- ORCID: 0000-0003-4998-2431
AD  - a Division of Maternal Fetal Medicine, Department of OBGYN and Women's Health , 
      Montefiore Medical Center, Albert Einstein College of Medicine , New York , NY , 
      USA.
FAU - Gutierrez, Megan
AU  - Gutierrez M
AD  - b Department of OBGYN , Saint Barnabas Medical Center , Livingston , NJ , USA.
FAU - Dziadosz, Margaret
AU  - Dziadosz M
AUID- ORCID: 0000-0003-4885-9191
AD  - b Department of OBGYN , Saint Barnabas Medical Center , Livingston , NJ , USA.
FAU - Bennett, Terri-Ann
AU  - Bennett TA
AD  - c Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology , 
      NYU Langone Medical Center, NYU School of Medicine , New York , NY , USA.
FAU - Dolin, Cara
AU  - Dolin C
AD  - c Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology , 
      NYU Langone Medical Center, NYU School of Medicine , New York , NY , USA.
FAU - Pham, Amelie
AU  - Pham A
AD  - d Department of Obstetrics and Gynecology , George Washington University School 
      of Medicine and Health Science , Washington, DC , USA.
FAU - Herbst, Allyson
AU  - Herbst A
AD  - e Department of Internal Medicine , Emory University School of Medicine , Atlanta 
      , GA , USA.
FAU - Lee, Sarah
AU  - Lee S
AD  - c Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology , 
      NYU Langone Medical Center, NYU School of Medicine , New York , NY , USA.
FAU - Roman, Ashley S
AU  - Roman AS
AD  - c Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology , 
      NYU Langone Medical Center, NYU School of Medicine , New York , NY , USA.
LA  - eng
PT  - Journal Article
DEP - 20170912
PL  - England
TA  - J Matern Fetal Neonatal Med
JT  - The journal of maternal-fetal & neonatal medicine : the official journal of the 
      European Association of Perinatal Medicine, the Federation of Asia and Oceania 
      Perinatal Societies, the International Society of Perinatal Obstetricians
JID - 101136916
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - Case-Control Studies
MH  - Female
MH  - Gestational Age
MH  - Humans
MH  - Pregnancy
MH  - Pregnancy Outcome/*epidemiology
MH  - Prehypertension/*epidemiology/*pathology/physiopathology
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Adverse outcomes
OT  - hypertension
OT  - pregnancy
OT  - prehypertension
EDAT- 2017/09/05 06:00
MHDA- 2019/02/15 06:00
CRDT- 2017/09/05 06:00
PHST- 2017/09/05 06:00 [pubmed]
PHST- 2019/02/15 06:00 [medline]
PHST- 2017/09/05 06:00 [entrez]
AID - 10.1080/14767058.2017.1374363 [doi]
PST - ppublish
SO  - J Matern Fetal Neonatal Med. 2019 Jan;32(2):188-192. doi: 
      10.1080/14767058.2017.1374363. Epub 2017 Sep 12.