PMID- 28868971
OWN - NLM
STAT- MEDLINE
DCOM- 20181108
LR  - 20181202
IS  - 1748-6963 (Electronic)
IS  - 1743-5889 (Linking)
VI  - 12
IP  - 19
DP  - 2017 Oct
TI  - Mucoadhesive solid lipid microparticles for controlled release of a 
      corticosteroid in the chronic obstructive pulmonary disease treatment.
PG  - 2287-2302
LID - 10.2217/nnm-2017-0072 [doi]
AB  - AIM: Therapeutic efficacy of pulmonary diseases is often limited and drug 
      delivery systems offer new solutions to clinical problems. Solid lipid 
      microparticles (SLMs) are suggested as systems for the delivery of therapeutics 
      to the lung as, because of their size, they are able to deposit into secondary 
      bronchi. MATERIALS & METHODS: Here, we describe two novel different SLMs using 
      chitosan and alginate such as mucoadhesive polymers and we also studied their 
      biocompatibility and their effectiveness compared with the free drug in 
      controlling senescence and inflammatory processes in cigarette smoke extracts. 
      RESULTS: Data reported show that fluticasone propionate (FP)-loaded SLMs are more 
      effective than FP alone in controlling oxidative stress. CONCLUSION: The 
      therapeutic approach using FP-loaded microparticles could be a promising strategy 
      for the treatment of the chronic inflammatory pulmonary diseases.
FAU - Amore, Erika
AU  - Amore E
AD  - Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche 
      (STEBICEF), Universita degli Studi di Palermo, Via Archirafi 32, 90123 Palermo, 
      Italy.
FAU - Ferraro, Maria
AU  - Ferraro M
AD  - Istituto di Biomedicina e Immunologia Molecolare (IBIM), CNR, Via Ugo La Malfa 
      153, 90146 Palermo, Italy.
FAU - Manca, Maria Letizia
AU  - Manca ML
AD  - Dipartimento Scienze della Vita e dell'Ambiente, Sezione Scienze del Farmaco, 
      Universita degli Studi di Cagliari, Via Ospedale 72, 09124 Cagliari, Italy.
FAU - Gjomarkaj, Mark
AU  - Gjomarkaj M
AD  - Istituto di Biomedicina e Immunologia Molecolare (IBIM), CNR, Via Ugo La Malfa 
      153, 90146 Palermo, Italy.
FAU - Giammona, Gaetano
AU  - Giammona G
AD  - Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche 
      (STEBICEF), Universita degli Studi di Palermo, Via Archirafi 32, 90123 Palermo, 
      Italy.
FAU - Pace, Elisabetta
AU  - Pace E
AD  - Istituto di Biomedicina e Immunologia Molecolare (IBIM), CNR, Via Ugo La Malfa 
      153, 90146 Palermo, Italy.
FAU - Bondi, Maria Luisa
AU  - Bondi ML
AD  - Istituto per lo Studio dei Materiali Nanostrutturati (ISMN), U.O.S. Palermo, CNR, 
      Via Ugo La Malfa 153, 90146 Palermo, Italy.
LA  - eng
PT  - Journal Article
DEP - 20170904
PL  - England
TA  - Nanomedicine (Lond)
JT  - Nanomedicine (London, England)
JID - 101278111
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (Alginates)
RN  - 0 (Biocompatible Materials)
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Drug Carriers)
RN  - 0 (Hexuronic Acids)
RN  - 0 (Lipids)
RN  - 8A5D83Q4RW (Glucuronic Acid)
RN  - 9012-76-4 (Chitosan)
RN  - CUT2W21N7U (Fluticasone)
SB  - IM
MH  - Administration, Inhalation
MH  - Adrenal Cortex Hormones/*administration & dosage
MH  - Alginates/chemistry
MH  - Biocompatible Materials/chemistry
MH  - Cell Survival
MH  - Chitosan/chemistry
MH  - Chromatography, High Pressure Liquid/methods
MH  - Delayed-Action Preparations
MH  - Drug Carriers/*chemistry
MH  - Drug Liberation
MH  - Drug Stability
MH  - Epithelial Cells
MH  - Fluticasone/*administration & dosage
MH  - Glucuronic Acid/chemistry
MH  - Hexuronic Acids/chemistry
MH  - Humans
MH  - Lipids/*chemistry
MH  - Lung/drug effects/metabolism
MH  - Microscopy, Electron, Scanning/methods
MH  - Microspheres
MH  - Oxidative Stress/drug effects
MH  - Particle Size
MH  - Pulmonary Disease, Chronic Obstructive/*drug therapy
MH  - Surface Properties
OTO - NOTNLM
OT  - aerodynamic diameter
OT  - chronic obstructive pulmonary disease (COPD)
OT  - mucoadhesive solid lipid microparticles (SLMs)
EDAT- 2017/09/05 06:00
MHDA- 2018/11/09 06:00
CRDT- 2017/09/05 06:00
PHST- 2017/09/05 06:00 [pubmed]
PHST- 2018/11/09 06:00 [medline]
PHST- 2017/09/05 06:00 [entrez]
AID - 10.2217/nnm-2017-0072 [doi]
PST - ppublish
SO  - Nanomedicine (Lond). 2017 Oct;12(19):2287-2302. doi: 10.2217/nnm-2017-0072. Epub 
      2017 Sep 4.