PMID- 28869392
OWN - NLM
STAT- MEDLINE
DCOM- 20180125
LR  - 20180125
IS  - 1752-0371 (Electronic)
IS  - 1752-0363 (Linking)
VI  - 11
IP  - 11
DP  - 2017 Nov
TI  - Intracranial pressure-induced optic nerve sheath response as a predictive 
      biomarker for optic disc edema in astronauts.
PG  - 1003-1008
LID - 10.2217/bmm-2017-0218 [doi]
AB  - A significant proportion of the astronauts who spend extended periods in 
      microgravity develop ophthalmic abnormalities. Understanding this syndrome, 
      called visual impairment and intracranial pressure (VIIP), has become a high 
      priority for National Aeronautics and Space Administration, especially in view of 
      future long-duration missions (e.g., Mars missions). Moreover, to ensure 
      selection of astronaut candidates who will be able to complete long-duration 
      missions with low risk of the VIIP syndrome, it is imperative to identify 
      biomarkers for VIIP risk prediction. Here, we hypothesize that the optic nerve 
      sheath response to alterations in intracranial pressure may be a potential 
      predictive biomarker for optic disc edema in astronauts. If confirmed, this 
      biomarker could be used for preflight identification of astronauts at risk for 
      developing VIIP-associated optic disc edema.
FAU - Wostyn, Peter
AU  - Wostyn P
AD  - Department of Psychiatry, PC Sint-Amandus, 8730 Beernem, Belgium.
FAU - De Deyn, Peter Paul
AU  - De Deyn PP
AD  - Laboratory of Neurochemistry & Behavior, Institute Born-Bunge, University of 
      Antwerp, Department of Biomedical Sciences, 2610 Antwerp, Belgium.
AD  - Department of Neurology & Alzheimer Research Center, University of Groningen & 
      University Medical Center Groningen, 9700 RB Groningen, The Netherlands.
AD  - Department of Neurology & Memory Clinic, Middelheim General Hospital (ZNA), 2020 
      Antwerp, Belgium.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170904
PL  - England
TA  - Biomark Med
JT  - Biomarkers in medicine
JID - 101312535
RN  - 0 (Biomarkers)
SB  - IM
MH  - *Astronauts
MH  - Biomarkers/metabolism
MH  - Female
MH  - Humans
MH  - *Intracranial Pressure
MH  - Male
MH  - Optic Nerve/*metabolism/pathology/physiopathology
MH  - Papilledema/*metabolism/pathology/physiopathology
MH  - Syndrome
MH  - Vision Disorders/*metabolism/pathology/physiopathology
OTO - NOTNLM
OT  - astronaut
OT  - biomarker
OT  - cerebrospinal fluid pressure
OT  - glymphatic system
OT  - intracranial pressure
OT  - intrathecal infusion test
OT  - long-duration spaceflight
OT  - optic disc edema
OT  - optic nerve sheath diameter
OT  - visual impairment and intracranial pressure syndrome
EDAT- 2017/09/05 06:00
MHDA- 2018/01/26 06:00
CRDT- 2017/09/05 06:00
PHST- 2017/09/05 06:00 [pubmed]
PHST- 2018/01/26 06:00 [medline]
PHST- 2017/09/05 06:00 [entrez]
AID - 10.2217/bmm-2017-0218 [doi]
PST - ppublish
SO  - Biomark Med. 2017 Nov;11(11):1003-1008. doi: 10.2217/bmm-2017-0218. Epub 2017 Sep 
      4.