PMID- 28869876
OWN - NLM
STAT- MEDLINE
DCOM- 20180307
LR  - 20181202
IS  - 1873-6750 (Electronic)
IS  - 0160-4120 (Linking)
VI  - 108
DP  - 2017 Nov
TI  - Associations between internal exposure levels of persistent organic pollutants in 
      adipose tissue and deep infiltrating endometriosis with or without concurrent 
      ovarian endometrioma.
PG  - 195-203
LID - S0160-4120(17)30853-X [pii]
LID - 10.1016/j.envint.2017.08.019 [doi]
AB  - Endometriosis is a gynaecological disease characterized by the presence of 
      ectopic endometrial tissue. Histologically, it appears as different sub-types, 
      being peritoneal endometriosis, ovarian endometrioma (OvE) and deep infiltrating 
      endometriosis (DIE), which are of major relevance due to their varying clinical 
      presentations. A number of persistent organic pollutants (POPs) have been 
      associated with the onset of endometriosis, yet the overall set of existing 
      studies remains fairly divergent. In this preliminary case-control study we aimed 
      to assess the potential associations between the internal exposure to POPs and 
      the presence of DIE with or without concurrent OvE. Adipose tissue and serum 
      samples were collected from surgically confirmed cases (n=55) and controls (n=44) 
      enrolled during 2013 and 2015 in Pays de la Loire, France. Targeted pollutants 
      (76 historical or more emerging POPs including dioxins, polychlorobiphenyls 
      (PCB), polybrominated diphenyl ethers (PBDEs), polybrominated biphenyls (PBBs), 
      hexabromocyclododecanes (HBCDs) and organochlorine pesticides (OCPs) were 
      quantified by chromatography coupled to mass spectrometry. Odds ratios (ORs) and 
      95% confidence intervals (CI) were estimated from unconditional logistic 
      regression adjusted for known confounding variables. The results showed 
      significant associations between DIE and adipose tissue levels of 1.2.3.7.8 - 
      PeCDD, OCDF, PCB 105, 114, 118 and 123, PBDE 183, PBB 153, and several OCPs 
      including trans‑nonachlor, cis‑heptachlor epoxide, dieldrin, 
      beta-hexachlorocyclohexane and hexachlorobenzene. The largest associations were 
      observed for OCDF followed by cis‑heptachlor epoxide, exhibiting adjusted ORs 
      (95% CI) of 5.42 (2.73-12.85) and 5.36 (2.44-14.84) per 1-SD increase, 
      respectively. The stratified analysis comparing both disease sub-types suggested 
      that adipose tissue exposure markers may be more associated with DIE concurrent 
      with OvE, however these results need to be confirmed in a larger population.
CI  - Copyright (c) 2017. Published by Elsevier Ltd.
FAU - Ploteau, Stephane
AU  - Ploteau S
AD  - LUNAM Universite, Oniris, UMR 1329 Laboratoire d'Etude des Residus et 
      Contaminants dans les Aliments (LABERCA), Nantes, France; Service de 
      gynecologie-obstetrique, CIC FEA, Hopital Mere Enfant, CHU Hotel Dieu, Nantes, 
      France.
FAU - Cano-Sancho, German
AU  - Cano-Sancho G
AD  - LUNAM Universite, Oniris, UMR 1329 Laboratoire d'Etude des Residus et 
      Contaminants dans les Aliments (LABERCA), Nantes, France; INRA Centre 
      Angers-Nantes, Nantes F-44307, France. Electronic address: 
      laberca@oniris-nantes.fr.
FAU - Volteau, Christelle
AU  - Volteau C
AD  - Plateforme Biometrie, CHU Hotel Dieu, Nantes, France.
FAU - Legrand, Arnaud
AU  - Legrand A
AD  - Service de gynecologie-obstetrique, CIC FEA, Hopital Mere Enfant, CHU Hotel Dieu, 
      Nantes, France.
FAU - Venisseau, Anais
AU  - Venisseau A
AD  - LUNAM Universite, Oniris, UMR 1329 Laboratoire d'Etude des Residus et 
      Contaminants dans les Aliments (LABERCA), Nantes, France.
FAU - Vacher, Vincent
AU  - Vacher V
AD  - LUNAM Universite, Oniris, UMR 1329 Laboratoire d'Etude des Residus et 
      Contaminants dans les Aliments (LABERCA), Nantes, France.
FAU - Marchand, Philippe
AU  - Marchand P
AD  - LUNAM Universite, Oniris, UMR 1329 Laboratoire d'Etude des Residus et 
      Contaminants dans les Aliments (LABERCA), Nantes, France.
FAU - Le Bizec, Bruno
AU  - Le Bizec B
AD  - LUNAM Universite, Oniris, UMR 1329 Laboratoire d'Etude des Residus et 
      Contaminants dans les Aliments (LABERCA), Nantes, France.
FAU - Antignac, Jean-Philippe
AU  - Antignac JP
AD  - LUNAM Universite, Oniris, UMR 1329 Laboratoire d'Etude des Residus et 
      Contaminants dans les Aliments (LABERCA), Nantes, France; INRA Centre 
      Angers-Nantes, Nantes F-44307, France.
LA  - eng
PT  - Journal Article
DEP - 20170903
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Pesticides)
SB  - IM
MH  - Adipose Tissue/*chemistry
MH  - Adult
MH  - Case-Control Studies
MH  - Endocrine Disruptors/adverse effects
MH  - Endometriosis/*chemically induced
MH  - *Environmental Exposure
MH  - Environmental Pollutants/*adverse effects/analysis
MH  - Female
MH  - Humans
MH  - Pesticides/adverse effects/analysis
OTO - NOTNLM
OT  - Deep infiltrating endometriosis
OT  - Dioxins
OT  - Endocrine-disrupting chemicals
OT  - Organochlorine pesticides
OT  - Ovarian endometrioma
OT  - Polychlorinated biphenyls
EDAT- 2017/09/05 06:00
MHDA- 2018/03/08 06:00
CRDT- 2017/09/05 06:00
PHST- 2017/05/11 00:00 [received]
PHST- 2017/08/29 00:00 [revised]
PHST- 2017/08/29 00:00 [accepted]
PHST- 2017/09/05 06:00 [pubmed]
PHST- 2018/03/08 06:00 [medline]
PHST- 2017/09/05 06:00 [entrez]
AID - S0160-4120(17)30853-X [pii]
AID - 10.1016/j.envint.2017.08.019 [doi]
PST - ppublish
SO  - Environ Int. 2017 Nov;108:195-203. doi: 10.1016/j.envint.2017.08.019. Epub 2017 
      Sep 3.