PMID- 2886996
OWN - NLM
STAT- MEDLINE
DCOM- 19870828
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 27
IP  - 1
DP  - 1987 May
TI  - MDMA as a discriminative stimulus: isomeric comparisons.
PG  - 41-4
AB  - Using a two-lever, food-motivated discrimination procedure, eight male rats were 
      trained to discriminate 1.5 mg/kg of racemic 3,4-methylenedioxymethamphetamine 
      (MDMA) from its vehicle, distilled water. Once trained, the rats demonstrated a 
      dose-related decrease in discriminative performance after administration of lower 
      doses of MDMA (ED50 = 0.27 mg/kg). Racemic MDMA-stimulus generalization occurred 
      with both isomers of MDMA with the ED50 of the (+) isomer calculated as 0.50 
      mg/kg and for the (-) isomer being 1.07. Time-course data indicate that racemic 
      MDMA has a peak effect from 20-60 min post-injection with a declining effect from 
      120-240 min. This time-course closely resembles that observed by subjective 
      reports in human abusers and, together with previous data, would indicate that 
      the discriminative paradigm would be useful in investigations as to the 
      neurochemical effects of MDMA.
FAU - Schechter, M D
AU  - Schechter MD
LA  - eng
GR  - 4181/PHS HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Amphetamines)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology
MH  - Amphetamines/*pharmacology
MH  - Animals
MH  - Conditioning, Operant/drug effects
MH  - Discrimination Learning/*drug effects
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Stereoisomerism
MH  - Time Factors
EDAT- 1987/05/01 00:00
MHDA- 1987/05/01 00:01
CRDT- 1987/05/01 00:00
PHST- 1987/05/01 00:00 [pubmed]
PHST- 1987/05/01 00:01 [medline]
PHST- 1987/05/01 00:00 [entrez]
AID - 0091-3057(87)90474-6 [pii]
AID - 10.1016/0091-3057(87)90474-6 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1987 May;27(1):41-4. doi: 10.1016/0091-3057(87)90474-6.