PMID- 28870510
OWN - NLM
STAT- MEDLINE
DCOM- 20181010
LR  - 20220318
IS  - 1876-4754 (Electronic)
IS  - 1876-4754 (Linking)
VI  - 10
IP  - 6
DP  - 2017 Nov-Dec
TI  - Repeated transcranial direct current stimulation improves cognitive dysfunction 
      and synaptic plasticity deficit in the prefrontal cortex of 
      streptozotocin-induced diabetic rats.
PG  - 1079-1087
LID - S1935-861X(17)30887-2 [pii]
LID - 10.1016/j.brs.2017.08.007 [doi]
AB  - BACKGROUND: Cognitive dysfunction is commonly observed in diabetic patients. We 
      have previously reported that anodal transcranial direct current stimulation 
      (tDCS) over the dorsolateral prefrontal cortex can facilitate visuospatial 
      working memory in diabetic patients with concomitant diabetic peripheral 
      neuropathy and mild cognitive impairment, but the underlying mechanisms remain 
      unclear. OBJECTIVE: We investigated the cellular mechanisms underlying the effect 
      of tDCS on cognitive decline in streptozotocin (STZ)-induced diabetic rats. 
      METHODS: STZ-induced diabetic rats were subjected to either repeated anodal tDCS 
      or sham stimulation over the medial prefrontal cortex (mPFC). Spatial working 
      memory performance in delayed nonmatch-to-place T maze task (DNMT), the induction 
      of long-term potentiation (LTP) in the mPFC, and dendritic morphology of 
      Golgi-stained pyramidal neurons in the mPFC were assessed. RESULTS: Repeated 
      applications of prefrontal anodal tDCS improved spatial working memory 
      performance in DNMT and restored the impaired mPFC LTP of diabetic rats. The mPFC 
      of tDCS-treated diabetic rats exhibited higher levels of brain-derived 
      neurotrophic factor (BDNF) protein and N-Methyl-d-aspartate receptor (NMDAR) 
      subunit mRNA and protein compared to sham stimulation group. Furthermore, anodal 
      tDCS significantly increased dendritic spine density on the apical dendrites of 
      mPFC layer V pyramidal cells in diabetic rats, whereas the complexity of basal 
      and apical dendritic trees was unaltered. CONCLUSIONS: Our findings suggest that 
      repeated anodal tDCS may improve spatial working memory performance in 
      streptozotocin-induced diabetic rats through augmentation of synaptic plasticity 
      that requires BDNF secretion and transcription/translation of NMDARs in the mPFC, 
      and support the therapeutic potential of tDCS for cognitive decline in diabetes 
      mellitus patients.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Wu, Yi-Jen
AU  - Wu YJ
AD  - Institute of Clinical Medicine, College of Medicine, National Cheng Kung 
      University, Tainan, Taiwan; Department of Neurology, National Cheng Kung 
      University Hospital, College of Medicine, National Cheng Kung University, Tainan, 
      Taiwan.
FAU - Lin, Chou-Ching
AU  - Lin CC
AD  - Department of Neurology, National Cheng Kung University Hospital, College of 
      Medicine, National Cheng Kung University, Tainan, Taiwan.
FAU - Yeh, Che-Ming
AU  - Yeh CM
AD  - Department of Pharmacology, College of Medicine, National Cheng Kung University, 
      Tainan, Taiwan.
FAU - Chien, Miao-Er
AU  - Chien ME
AD  - Department of Neurology, National Cheng Kung University Hospital, College of 
      Medicine, National Cheng Kung University, Tainan, Taiwan.
FAU - Tsao, Ming-Chung
AU  - Tsao MC
AD  - Department of Neurology, National Cheng Kung University Hospital, College of 
      Medicine, National Cheng Kung University, Tainan, Taiwan.
FAU - Tseng, Philip
AU  - Tseng P
AD  - Graduate Institute of Humanities in Medicine, Taipei Medical University, Taipei, 
      Taiwan; TMU Research Center for Brain and Consciousness, Taipei Medical 
      University, Taipei, Taiwan; Shuang Ho Hospital, Taipei Medical University, New 
      Taipei City, Taiwan.
FAU - Huang, Chin-Wei
AU  - Huang CW
AD  - Department of Neurology, National Cheng Kung University Hospital, College of 
      Medicine, National Cheng Kung University, Tainan, Taiwan.
FAU - Hsu, Kuei-Sen
AU  - Hsu KS
AD  - Department of Pharmacology, College of Medicine, National Cheng Kung University, 
      Tainan, Taiwan; Institute of Basic Medical Sciences, College of Medicine, 
      National Cheng Kung University, Tainan, Taiwan. Electronic address: 
      richard@mail.ncku.edu.tw.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170824
PL  - United States
TA  - Brain Stimul
JT  - Brain stimulation
JID - 101465726
RN  - 5W494URQ81 (Streptozocin)
SB  - IM
MH  - Animals
MH  - Cognitive Dysfunction/physiopathology/psychology/*therapy
MH  - Diabetes Mellitus, Experimental/physiopathology/psychology/*therapy
MH  - Long-Term Potentiation
MH  - Male
MH  - Memory, Short-Term/physiology
MH  - Neuronal Plasticity/*physiology
MH  - Prefrontal Cortex/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Streptozocin
MH  - Transcranial Direct Current Stimulation/*methods
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Cognitive function
OT  - Diabetes mellitus
OT  - Medial prefrontal cortex
OT  - N-Methyl-d-aspartate receptor
OT  - Transcranial direct current stimulation
EDAT- 2017/09/06 06:00
MHDA- 2018/10/12 06:00
CRDT- 2017/09/06 06:00
PHST- 2017/02/11 00:00 [received]
PHST- 2017/07/22 00:00 [revised]
PHST- 2017/08/22 00:00 [accepted]
PHST- 2017/09/06 06:00 [pubmed]
PHST- 2018/10/12 06:00 [medline]
PHST- 2017/09/06 06:00 [entrez]
AID - S1935-861X(17)30887-2 [pii]
AID - 10.1016/j.brs.2017.08.007 [doi]
PST - ppublish
SO  - Brain Stimul. 2017 Nov-Dec;10(6):1079-1087. doi: 10.1016/j.brs.2017.08.007. Epub 
      2017 Aug 24.