PMID- 28873980
OWN - NLM
STAT- MEDLINE
DCOM- 20180705
LR  - 20180718
IS  - 1460-2709 (Electronic)
IS  - 1369-3786 (Linking)
VI  - 55
IP  - 5
DP  - 2017 Jul 1
TI  - Human primary myeloid dendritic cells interact with the opportunistic fungal 
      pathogen Aspergillus fumigatus via the C-type lectin receptor Dectin-1.
PG  - 573-578
LID - 10.1093/mmy/myw105 [doi]
AB  - Aspergillus fumigatus is an opportunistic fungal pathogen causing detrimental 
      infections in immunocompromised individuals. Dendritic cells (DCs) are potent 
      antigen-presenting cells and recognize the A. fumigatus cell wall component beta-1,3 
      glucan via Dectin-1, followed by DC maturation and cytokine release. Here, we 
      demonstrate that human primary myeloid DCs (mDCs) interact with different 
      morphotypes of A. fumigatus. Dectin-1 is expressed on mDCs and is down-regulated 
      after contact with A. fumigatus, indicating that mDCs recognize A. fumigatus via 
      this receptor. Blocking of Dectin-1, followed by stimulation with depleted 
      zymosan diminished the up-regulation of the T-cell co-stimulatory molecules CD40, 
      CD80, HLA-DR and CCR7 on mDCs and led to decreased release of the cytokines 
      TNF-alpha, IL-8, IL-1beta and IL-10.
CI  - (c) The Author 2016. Published by Oxford University Press on behalf of The 
      International Society for Human and Animal Mycology. All rights reserved. For 
      permissions, please e-mail: journals.permissions@oup.com.
FAU - Hefter, Maike
AU  - Hefter M
AD  - Medizinische Klinik und Poliklinik II, University Hospital Wuerzburg, Wuerzburg, 
      Germany.
FAU - Lother, Jasmin
AU  - Lother J
AD  - Medizinische Klinik und Poliklinik II, University Hospital Wuerzburg, Wuerzburg, 
      Germany.
FAU - Weiss, Esther
AU  - Weiss E
AD  - Medizinische Klinik und Poliklinik II, University Hospital Wuerzburg, Wuerzburg, 
      Germany.
FAU - Schmitt, Anna Lena
AU  - Schmitt AL
AD  - Medizinische Klinik und Poliklinik II, University Hospital Wuerzburg, Wuerzburg, 
      Germany.
FAU - Fliesser, Mirjam
AU  - Fliesser M
AD  - Medizinische Klinik und Poliklinik II, University Hospital Wuerzburg, Wuerzburg, 
      Germany.
FAU - Einsele, Hermann
AU  - Einsele H
AD  - Medizinische Klinik und Poliklinik II, University Hospital Wuerzburg, Wuerzburg, 
      Germany.
FAU - Loeffler, Juergen
AU  - Loeffler J
AD  - Medizinische Klinik und Poliklinik II, University Hospital Wuerzburg, Wuerzburg, 
      Germany.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Med Mycol
JT  - Medical mycology
JID - 9815835
RN  - 0 (CLEC7A protein, human)
RN  - 0 (Cytokines)
RN  - 0 (Lectins, C-Type)
RN  - 0 (depleted zymosan)
RN  - 9010-72-4 (Zymosan)
SB  - IM
MH  - Aspergillus fumigatus/*immunology
MH  - Cells, Cultured
MH  - Cytokines/biosynthesis
MH  - Dendritic Cells/drug effects/*immunology/metabolism/microbiology
MH  - Down-Regulation/*immunology
MH  - Flow Cytometry
MH  - Host-Pathogen Interactions/*immunology
MH  - Humans
MH  - Lectins, C-Type/antagonists & inhibitors/drug effects/*immunology/metabolism
MH  - Zymosan/analogs & derivatives/pharmacology
OTO - NOTNLM
OT  - Aspergillus fumigatus
OT  - Dectin-1
OT  - blocking antibody
OT  - dendritic cells
OT  - myeloid
EDAT- 2017/09/07 06:00
MHDA- 2018/07/06 06:00
CRDT- 2017/09/07 06:00
PHST- 2016/05/24 00:00 [received]
PHST- 2016/09/22 00:00 [accepted]
PHST- 2017/09/07 06:00 [entrez]
PHST- 2017/09/07 06:00 [pubmed]
PHST- 2018/07/06 06:00 [medline]
AID - 2629005 [pii]
AID - 10.1093/mmy/myw105 [doi]
PST - ppublish
SO  - Med Mycol. 2017 Jul 1;55(5):573-578. doi: 10.1093/mmy/myw105.