PMID- 2887476
OWN - NLM
STAT- MEDLINE
DCOM- 19871008
LR  - 20190908
IS  - 0272-0590 (Print)
IS  - 0272-0590 (Linking)
VI  - 9
IP  - 1
DP  - 1987 Jul
TI  - Toxicity of methylenedioxymethamphetamine (MDMA) in the dog and the rat.
PG  - 110-9
AB  - Methylenedioxymethamphetamine (MDMA) was administered to dogs and rats orally 
      once a day for a 28-day period to evaluate the morphological and 
      neuropathological effects. Major clinical signs associated with the 
      administration of MDMA in the dog included circling, depression, dilated pupils, 
      hyperactivity, rapid breathing, and salivation. Major clinical signs in the rat 
      included hyperactivity, excitability, piloerection, exophthalmos, and salivation. 
      Gross observations at necropsy in the dog possibly related to administration of 
      the test article included reduced testicular size (one high and one medium dose) 
      and prostatic enlargement in two high-dose animals. No gross lesions were seen in 
      the rats at necropsy. The medium- and the high-dose groups in both sexes in both 
      the rats and the dogs gained significantly less weight than the control and 
      low-dose groups. Food consumption decreased the first week for the high- and 
      medium-dose groups, but a significant reversal toward more normal consumption was 
      noted in the following weeks in both the rats and the dogs. Hematologic, clinical 
      chemistry, and urinalysis values did not appear to be affected by the 
      administration of the test article in the dog. In the rat clinical pathology 
      variables showing a trend to decrease with dose included urinary pH, blood urea 
      nitrogen, glucose, creatinine (females), lactate dehydrogenase (LDH) (females), 
      and chloride. Clinical pathology variables showing a trend to increase with dose 
      included total white blood cell count and phosphorus. Microscopically, testicular 
      atrophy was present in one medium-dose and two high-dose male dogs. Prostatic 
      hyperplasia was present in two high-dose male dogs. No test article-related 
      lesions were seen in the brains of either species.
FAU - Frith, C H
AU  - Frith CH
FAU - Chang, L W
AU  - Chang LW
FAU - Lattin, D L
AU  - Lattin DL
FAU - Walls, R C
AU  - Walls RC
FAU - Hamm, J
AU  - Hamm J
FAU - Doblin, R
AU  - Doblin R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Fundam Appl Toxicol
JT  - Fundamental and applied toxicology : official journal of the Society of 
      Toxicology
JID - 8200838
RN  - 0 (Amphetamines)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/analogs & derivatives/*toxicity
MH  - Amphetamines/*toxicity
MH  - Animals
MH  - Body Weight/drug effects
MH  - Brain/drug effects
MH  - Dogs
MH  - Eating/drug effects
MH  - Female
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Organ Size/drug effects
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Substance-Related Disorders
EDAT- 1987/07/01 00:00
MHDA- 1987/07/01 00:01
CRDT- 1987/07/01 00:00
PHST- 1987/07/01 00:00 [pubmed]
PHST- 1987/07/01 00:01 [medline]
PHST- 1987/07/01 00:00 [entrez]
AID - 10.1016/0272-0590(87)90158-8 [doi]
PST - ppublish
SO  - Fundam Appl Toxicol. 1987 Jul;9(1):110-9. doi: 10.1016/0272-0590(87)90158-8.