PMID- 28877583 OWN - NLM STAT- MEDLINE DCOM- 20180124 LR - 20220129 IS - 2161-5063 (Electronic) IS - 2161-5063 (Linking) VI - 6 IP - 12 DP - 2017 Dec 15 TI - Leaf LIMS: A Flexible Laboratory Information Management System with a Synthetic Biology Focus. PG - 2273-2280 LID - 10.1021/acssynbio.7b00212 [doi] AB - This paper presents Leaf LIMS, a flexible laboratory information management system (LIMS) designed to address the complexity of synthetic biology workflows. At the project's inception there was a lack of a LIMS designed specifically to address synthetic biology processes, with most systems focused on either next generation sequencing or biobanks and clinical sample handling. Leaf LIMS implements integrated project, item, and laboratory stock tracking, offering complete sample and construct genealogy, materials and lot tracking, and modular assay data capture. Hence, it enables highly configurable task-based workflows and supports data capture from project inception to completion. As such, in addition to it supporting synthetic biology it is ideal for many laboratory environments with multiple projects and users. The system is deployed as a web application through Docker and is provided under a permissive MIT license. It is freely available for download at https://leaflims.github.io . FAU - Craig, Thomas AU - Craig T AUID- ORCID: 0000-0001-7029-310X AD - GeneMill, University of Liverpool , Liverpool L69 7ZB, U.K. FAU - Holland, Richard AU - Holland R AD - New Forest Ventures Ltd. , Fordingbridge SP6 1QX, U.K. FAU - D'Amore, Rosalinda AU - D'Amore R AD - Centre for Genomic Research, University of Liverpool , Liverpool L69 7ZB, U.K. FAU - Johnson, James R AU - Johnson JR AD - GeneMill, University of Liverpool , Liverpool L69 7ZB, U.K. FAU - McCue, Hannah V AU - McCue HV AD - GeneMill, University of Liverpool , Liverpool L69 7ZB, U.K. FAU - West, Anthony AU - West A AD - Earlham Institute , Norwich Research Park Innovation Centre, Colney Lane, Norwich NR4 7UH, U.K. FAU - Zulkower, Valentin AU - Zulkower V AD - Edinburgh Genome Foundry , Michael Swann Building, Max Born Crescent, Edinburgh EH9 3BF, U.K. FAU - Tekotte, Hille AU - Tekotte H AD - Edinburgh Genome Foundry , Michael Swann Building, Max Born Crescent, Edinburgh EH9 3BF, U.K. FAU - Cai, Yizhi AU - Cai Y AD - Edinburgh Genome Foundry , Michael Swann Building, Max Born Crescent, Edinburgh EH9 3BF, U.K. FAU - Swan, Daniel AU - Swan D AUID- ORCID: 0000-0001-8978-8129 AD - Earlham Institute , Norwich Research Park Innovation Centre, Colney Lane, Norwich NR4 7UH, U.K. FAU - Davey, Robert P AU - Davey RP AD - Earlham Institute , Norwich Research Park Innovation Centre, Colney Lane, Norwich NR4 7UH, U.K. FAU - Hertz-Fowler, Christiane AU - Hertz-Fowler C AD - Centre for Genomic Research, University of Liverpool , Liverpool L69 7ZB, U.K. FAU - Hall, Anthony AU - Hall A AD - Earlham Institute , Norwich Research Park Innovation Centre, Colney Lane, Norwich NR4 7UH, U.K. FAU - Caddick, Mark AU - Caddick M AD - GeneMill, University of Liverpool , Liverpool L69 7ZB, U.K. LA - eng GR - BB/M00029X/1/BB_/Biotechnology and Biological Sciences Research Council/United Kingdom GR - BB/M00094X/1/BB_/Biotechnology and Biological Sciences Research Council/United Kingdom GR - BB/M025659/1/BB_/Biotechnology and Biological Sciences Research Council/United Kingdom GR - BB/M005690/1/BB_/Biotechnology and Biological Sciences Research Council/United Kingdom GR - BB/M025640/1/BB_/Biotechnology and Biological Sciences Research Council/United Kingdom PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20170913 PL - United States TA - ACS Synth Biol JT - ACS synthetic biology JID - 101575075 SB - IM MH - *Database Management Systems MH - *Databases, Factual MH - *Synthetic Biology/instrumentation/methods OTO - NOTNLM OT - LIMS OT - automation OT - data management OT - lab information management system OT - synthetic biology EDAT- 2017/09/08 06:00 MHDA- 2018/01/25 06:00 CRDT- 2017/09/08 06:00 PHST- 2017/09/08 06:00 [pubmed] PHST- 2018/01/25 06:00 [medline] PHST- 2017/09/08 06:00 [entrez] AID - 10.1021/acssynbio.7b00212 [doi] PST - ppublish SO - ACS Synth Biol. 2017 Dec 15;6(12):2273-2280. doi: 10.1021/acssynbio.7b00212. Epub 2017 Sep 13.