PMID- 28879579
OWN - NLM
STAT- MEDLINE
DCOM- 20190523
LR  - 20191210
IS  - 1879-1123 (Electronic)
IS  - 1044-0305 (Linking)
VI  - 28
IP  - 12
DP  - 2017 Dec
TI  - Novel Selectivity-Based Forensic Toxicological Validation of a Paper Spray Mass 
      Spectrometry Method for the Quantitative Determination of Eight Amphetamines in 
      Whole Blood.
PG  - 2665-2676
LID - 10.1007/s13361-017-1790-0 [doi]
AB  - Paper spray tandem mass spectrometry is used to identify and quantify eight 
      individual amphetamines in whole blood in 1.3 min. The method has been optimized 
      and fully validated according to forensic toxicology guidelines, for the 
      quantification of amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine 
      (MDA), 3,4-methylenedioxy-N-methylamphetamine (MDMA), 
      3,4-methylenedioxy-N-ethylamphetamine (MDEA), para-methoxyamphetamine (PMA), 
      para-methoxymethamphetamine (PMMA), and 4-fluoroamphetamine (4-FA). Additionally, 
      a new concept of intrinsic and application-based selectivity is discussed, 
      featuring increased confidence in the power to discriminate the amphetamines from 
      other chemically similar compounds when applying an ambient mass spectrometric 
      method without chromatographic separation. Accuracy was within +/-15% and average 
      precision was better than 15%, and better than 20% at the LLOQ. Detection limits 
      between 15 and 50 ng/mL were obtained using only 12 muL of whole blood. Graphical 
      abstract ᅟ.
FAU - Teunissen, Sebastiaan F
AU  - Teunissen SF
AD  - ThoMSon Mass Spectrometry Laboratory, University of Campinas - UNICAMP, Campinas, 
      13083-970, Brazil.
AD  - Department of Chemistry and Center for Analytical Instrumentation, Purdue 
      University, West Lafayette, IN, 47907, USA.
FAU - Fedick, Patrick W
AU  - Fedick PW
AD  - Department of Chemistry and Center for Analytical Instrumentation, Purdue 
      University, West Lafayette, IN, 47907, USA.
FAU - Berendsen, Bjorn J A
AU  - Berendsen BJA
AD  - RIKILT, Wageningen Research, Akkermaalsbos 2, 6708 WB, P.O. Box 230, 6700 AE, 
      Wageningen, The Netherlands.
FAU - Nielen, Michel W F
AU  - Nielen MWF
AD  - RIKILT, Wageningen Research, Akkermaalsbos 2, 6708 WB, P.O. Box 230, 6700 AE, 
      Wageningen, The Netherlands.
AD  - Laboratory of Organic Chemistry, Wageningen University, Stippeneng 4, 6708 WE, 
      Wageningen, The Netherlands.
FAU - Eberlin, Marcos N
AU  - Eberlin MN
AD  - ThoMSon Mass Spectrometry Laboratory, University of Campinas - UNICAMP, Campinas, 
      13083-970, Brazil.
FAU - Graham Cooks, R
AU  - Graham Cooks R
AD  - Department of Chemistry and Center for Analytical Instrumentation, Purdue 
      University, West Lafayette, IN, 47907, USA.
FAU - van Asten, Arian C
AU  - van Asten AC
AD  - Netherlands Forensic Institute, P.O. Box 24044, 2490 AA, The Hague, The 
      Netherlands. a.van.asten@nfi.minvenj.nl.
AD  - Faculty of Science, Van 't Hoff Institute for Molecular Sciences, University of 
      Amsterdam, P.O. Box 94157, 1090 GD, Amsterdam, The Netherlands. 
      a.van.asten@nfi.minvenj.nl.
AD  - CLHC, Amsterdam Center for Forensic Science and Medicine, P.O. Box 94157, 1090 
      GD, Amsterdam, The Netherlands. a.van.asten@nfi.minvenj.nl.
LA  - eng
PT  - Journal Article
PT  - Validation Study
DEP - 20170906
PL  - United States
TA  - J Am Soc Mass Spectrom
JT  - Journal of the American Society for Mass Spectrometry
JID - 9010412
RN  - 0 (Central Nervous System Stimulants)
RN  - CK833KGX7E (Amphetamine)
SB  - IM
MH  - Amphetamine/analysis/*blood
MH  - Central Nervous System Stimulants/analysis/*blood
MH  - Forensic Toxicology/*methods
MH  - Humans
MH  - Limit of Detection
MH  - Mass Spectrometry/*methods
MH  - Paper
MH  - Reproducibility of Results
MH  - Substance Abuse Detection/methods
OTO - NOTNLM
OT  - Amphetamines
OT  - Forensic toxicology
OT  - Paper spray mass spectrometry
OT  - Selectivity
OT  - Validation
OT  - Whole blood
EDAT- 2017/09/08 06:00
MHDA- 2019/05/24 06:00
CRDT- 2017/09/08 06:00
PHST- 2017/06/26 00:00 [received]
PHST- 2017/08/10 00:00 [accepted]
PHST- 2017/08/09 00:00 [revised]
PHST- 2017/09/08 06:00 [pubmed]
PHST- 2019/05/24 06:00 [medline]
PHST- 2017/09/08 06:00 [entrez]
AID - 10.1007/s13361-017-1790-0 [pii]
AID - 10.1007/s13361-017-1790-0 [doi]
PST - ppublish
SO  - J Am Soc Mass Spectrom. 2017 Dec;28(12):2665-2676. doi: 
      10.1007/s13361-017-1790-0. Epub 2017 Sep 6.