PMID- 28879742
OWN - NLM
STAT- MEDLINE
DCOM- 20180515
LR  - 20181202
IS  - 1001-5302 (Print)
IS  - 1001-5302 (Linking)
VI  - 41
IP  - 7
DP  - 2016 Apr
TI  - [Effect of six class of Kaixin San formulas on pharmacological and preliminary 
      mechanism of Alzheimer's disease mice].
PG  - 1269-1274
LID - 10.4268/cjcmm20160718 [doi]
AB  - The efficacy of Chinese herbal formulas in treating Alzheimer has been proved in 
      many studies. In this study, six different Kaixin San formulas were compared to 
      investigate their effects on learning and memory decline, brain-derived 
      neurotrophic factor (BDNF) in the hippocampus, tau protein, acetylcholinesterase 
      (AChE) and N-terminal pro-brain natriuretic peptide (NT-proBNP). Kunming mice 
      were selected and established a mouse model of Alzheimer's by intraperitoneal 
      injection of D-galactose and sodium nitrite, continued intragastric 4 weeks, 
      using the ability of learning and memory in Morris water maze test to evaluate 
      the animals in each group; the content of BDNF in the hippocampus of mice with 
      Western blotting detected; ELISA method for the detection of each group of mice 
      hippocampal tau protein,p-Tau protein, Abeta,Ach,AchE and serum NT-proBNP levels. 
      The results showed that, Kaixin San of Qianjin Yaofang three dose recorded 
      significantly improved learning and memory ability of mice; increased the content 
      of BDNF and Ach in the hippocampus; decreased the content of Abeta, Tau protein, 
      p-Tau protein in the hippocampus; high, middle dose significantly decreased the 
      serum NT-proBNP and AchE in hippocampus, the effect is most significant. Part 
      dose of Kaixin San of Yixin Fang, Kaixin Wan of Yimen Fang, Dingzhi Xiaowan of 
      Beji Qianjin Yaofang and Dingzhi Wan of Guji Luyan could improve the learning and 
      memory ability evaluation indicators, significantly increased BDNF and Ach in the 
      hippocampus of AD model mice, reduced the Abeta, Tau protein, p-Tau protein in 
      hippocampus of AD model mice, decreased the NT-proBNP and AchE in serum of AD 
      mice, the effect is more significant. Three does of Buxin Tang of Qianjin Yi had 
      no effects of treatment in Alzheimer's disease. The results showed the treatment 
      in AD of Kaixin San of Qianjin Yaofang is the most significant.
CI  - Copyright(c) by the Chinese Pharmaceutical Association.
FAU - Li, Mu-Han
AU  - Li MH
AD  - Beijing University of Chinese Medicine, Beijing 100029, China.
AD  - Department of Clinical Pharmacology and Pharmacy, Chinese PLA General Hospital, 
      Beijing 100853, China.
FAU - Zhang, Jing
AU  - Zhang J
AD  - Department of Clinical Pharmacology and Pharmacy, Chinese PLA General Hospital, 
      Beijing 100853, China.
FAU - Zhao, Run-Qing
AU  - Zhao RQ
AD  - Department of Clinical Pharmacology and Pharmacy, Chinese PLA General Hospital, 
      Beijing 100853, China.
FAU - Dong, Xian-Zhe
AU  - Dong XZ
AD  - Department of Clinical Pharmacology and Pharmacy, Chinese PLA General Hospital, 
      Beijing 100853, China.
FAU - Hu, Yuan
AU  - Hu Y
AD  - Department of Clinical Pharmacology and Pharmacy, Chinese PLA General Hospital, 
      Beijing 100853, China.
FAU - Chen, Ting
AU  - Chen T
AD  - Department of Clinical Pharmacology and Pharmacy, Chinese PLA General Hospital, 
      Beijing 100853, China.
FAU - Li, Jie
AU  - Li J
AD  - Department of Clinical Pharmacology and Pharmacy, Chinese PLA General Hospital, 
      Beijing 100853, China.
FAU - Liu, Li
AU  - Liu L
AD  - Department of Clinical Pharmacology and Pharmacy, Chinese PLA General Hospital, 
      Beijing 100853, China.
FAU - Liu, Ping
AU  - Liu P
AD  - Department of Clinical Pharmacology and Pharmacy, Chinese PLA General Hospital, 
      Beijing 100853, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhongguo Zhong Yao Za Zhi
JT  - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese 
      materia medica
JID - 8913656
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (GPI-Linked Proteins)
RN  - 0 (Peptide Fragments)
RN  - 0 (kaixin)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 0 (tau Proteins)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - EC 3.1.1.7 (Acetylcholinesterase)
RN  - EC 3.1.1.7 (Ache protein, mouse)
SB  - IM
MH  - Acetylcholinesterase/blood
MH  - Alzheimer Disease/*drug therapy
MH  - Amyloid beta-Peptides
MH  - Animals
MH  - Disease Models, Animal
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - GPI-Linked Proteins/blood
MH  - Hippocampus/drug effects
MH  - Maze Learning
MH  - Mice
MH  - Natriuretic Peptide, Brain/blood
MH  - Peptide Fragments/blood
MH  - tau Proteins/blood
OTO - NOTNLM
OT  - Alzheimer
OT  - Alzheimer disease mouse model
OT  - Kaixin San formulas
OT  - Tau protein
COIS- The authors of this article and the planning committee members and staff have no 
      relevant financial relationships with commercial interests to disclose.
EDAT- 2016/04/01 00:00
MHDA- 2018/05/16 06:00
CRDT- 2017/09/08 06:00
PHST- 2015/12/08 00:00 [received]
PHST- 2017/09/08 06:00 [entrez]
PHST- 2016/04/01 00:00 [pubmed]
PHST- 2018/05/16 06:00 [medline]
AID - 10.4268/cjcmm20160718 [doi]
PST - ppublish
SO  - Zhongguo Zhong Yao Za Zhi. 2016 Apr;41(7):1269-1274. doi: 10.4268/cjcmm20160718.