PMID- 28880430
OWN - NLM
STAT- MEDLINE
DCOM- 20180608
LR  - 20191207
IS  - 1744-9987 (Electronic)
IS  - 1744-9979 (Print)
IS  - 1744-9979 (Linking)
VI  - 21
IP  - 5
DP  - 2017 Oct
TI  - Human Leukocyte Antigen Sensitization in Solid Organ Transplantation: A Primer on 
      Terminology, Testing, and Clinical Significance for the Apheresis Practitioner.
PG  - 441-450
LID - 10.1111/1744-9987.12570 [doi]
AB  - The human leukocyte antigen (HLA) system is an important immunologic barrier that 
      must be considered for successful solid organ transplantation. Formation of 
      donor-specific HLA antibodies in solid organ transplantation is an important 
      cause of allograft injury and may contribute to recipient morbidity and 
      mortality. Therapeutic plasma exchange is often requested to lower HLA antibody 
      levels prior to or after transplantation and for management of HLA antibodies in 
      the context of organ rejection. In this review, we summarize the current 
      terminology, laboratory testing, and clinical significance of HLA sensitization 
      in the solid organ transplant population. Furthermore, to illustrate applications 
      of HLA testing in clinical practice, we summarize our own lung and kidney 
      institutional protocols for managing HLA antibodies in the peri-transplant 
      setting.
CI  - (c) 2017 International Society for Apheresis, Japanese Society for Apheresis, and 
      Japanese Society for Dialysis Therapy.
FAU - Abbes, Sarah
AU  - Abbes S
AD  - Institut du thorax, Service de pneumologie et unite de transplantation 
      thoracique, Centre Hospitalier Universitaire, Nantes, France.
AD  - Department of Medicine, Division of Hematology, Duke University School of 
      Medicine, Durham, NC, USA.
FAU - Metjian, Ara
AU  - Metjian A
AD  - Department of Medicine, Division of Hematology, Duke University School of 
      Medicine, Durham, NC, USA.
FAU - Gray, Alice
AU  - Gray A
AD  - Department of Medicine, Division of Pulmonary, Allergy, and Critical Care 
      Medicine, Duke University School of Medicine, Durham, NC, USA.
FAU - Martinu, Tereza
AU  - Martinu T
AD  - Department of Medicine, Division of Pulmonary, Allergy, and Critical Care 
      Medicine, Duke University School of Medicine, Durham, NC, USA.
AD  - Department of Medicine, Division of Respirology, University of Toronto, Toronto, 
      ON, Canada.
FAU - Snyder, Laurie
AU  - Snyder L
AD  - Department of Medicine, Division of Pulmonary, Allergy, and Critical Care 
      Medicine, Duke University School of Medicine, Durham, NC, USA.
FAU - Chen, Dong-Feng
AU  - Chen DF
AD  - Department of Pathology, Division of Pathology Clinical Services, Duke University 
      School of Medicine, Durham, NC, USA.
FAU - Ellis, Matthew
AU  - Ellis M
AD  - Department of Medicine, Division of Nephrology, Duke University School of 
      Medicine, Durham, NC, USA.
FAU - Arepally, Gowthami M
AU  - Arepally GM
AD  - Department of Medicine, Division of Hematology, Duke University School of 
      Medicine, Durham, NC, USA.
FAU - Onwuemene, Oluwatoyosi
AU  - Onwuemene O
AUID- ORCID: 0000-0001-7266-7101
AD  - Department of Medicine, Division of Hematology, Duke University School of 
      Medicine, Durham, NC, USA.
LA  - eng
GR  - K12 HL087097/HL/NHLBI NIH HHS/United States
GR  - L30 HL129439/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20170907
PL  - Australia
TA  - Ther Apher Dial
JT  - Therapeutic apheresis and dialysis : official peer-reviewed journal of the 
      International Society for Apheresis, the Japanese Society for Apheresis, the 
      Japanese Society for Dialysis Therapy
JID - 101181252
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Blood Component Removal/*methods
MH  - Graft Rejection/immunology
MH  - HLA Antigens/*immunology
MH  - Humans
MH  - Kidney Transplantation/methods
MH  - Lung Transplantation/methods
MH  - Organ Transplantation/*methods
MH  - Plasma Exchange/methods
MH  - Terminology as Topic
MH  - Tissue Donors
PMC - PMC6890204
MID - NIHMS1058257
OTO - NOTNLM
OT  - Human leukocyte antigen antibodies
OT  - Human leukocyte antigen sensitization
OT  - Solid organ transplantation
OT  - Therapeutic plasma exchange
EDAT- 2017/09/08 06:00
MHDA- 2018/06/09 06:00
PMCR- 2019/12/03
CRDT- 2017/09/08 06:00
PHST- 2016/12/20 00:00 [received]
PHST- 2017/03/24 00:00 [revised]
PHST- 2017/04/25 00:00 [accepted]
PHST- 2017/09/08 06:00 [pubmed]
PHST- 2018/06/09 06:00 [medline]
PHST- 2017/09/08 06:00 [entrez]
PHST- 2019/12/03 00:00 [pmc-release]
AID - 10.1111/1744-9987.12570 [doi]
PST - ppublish
SO  - Ther Apher Dial. 2017 Oct;21(5):441-450. doi: 10.1111/1744-9987.12570. Epub 2017 
      Sep 7.