PMID- 28881103
OWN - NLM
STAT- MEDLINE
DCOM- 20181024
LR  - 20181024
IS  - 1365-3148 (Electronic)
IS  - 0958-7578 (Linking)
VI  - 27
IP  - 6
DP  - 2017 Dec
TI  - HLA polymorphisms and risk of red blood cell alloimmunisation in polytransfused 
      patients with sickle cell anaemia.
PG  - 437-443
LID - 10.1111/tme.12459 [doi]
AB  - BACKGROUND: Red blood cell (RBC) alloimmunisation is an event that may occur due 
      to factors such as numerous blood transfusions, age, gender and genetic factors 
      such as human leukocyte antigen (HLA). AIMS/OBJECTIVES: The aim of the present 
      study was to investigate the possibility of alloimmunisation to red blood cell 
      group antigens associated with the HLA of individuals and to relate 
      alloimmunisation to risk factors. METHODS: A total of 172 polytransfused patients 
      with sickle cell anaemia (SCA) (44 alloimmunised, 128 non-alloimmunised) 
      participated in this study. Blood group genotyping was performed by the DNA 
      microarray method and HLA genotyping by polymerase chain reaction - specific 
      sequence of oligonucleotides. RESULTS: The number of transfusions received 
      directly influenced the incidence of alloimmunisation, and the most common 
      alloantibodies were against Rh (48.8%) and Kell (17%) systems. The HLA-C*06 and 
      HLA-DQB1*03 variants were significantly higher in alloimmunised patients. The 
      HLA-DRB1*04 and HLA-DRB1*11 were more often found in individuals who developed 
      the alloantibodies anti-Fy(a) and anti-K, respectively. CONCLUSION: This study 
      suggests that polytransfused patients with SCA possessing the HLA-DQB1*03 and 
      HLA-C*06 allele variants are more susceptible to alloimmunisation. In addition, 
      HLA-DRB1*04 and HLA-DRB1*11 alleles were seen to be associated with the 
      production of anti-Fy(a) and anti-K antibodies, respectively.
CI  - (c) 2017 British Blood Transfusion Society.
FAU - Rodrigues, C
AU  - Rodrigues C
AD  - Immunogenetics Laboratory, Basic Health Sciences Department, State University of 
      Maringa, Maringa, PR, Brazil.
FAU - Sell, A M
AU  - Sell AM
AD  - Immunogenetics Laboratory, Basic Health Sciences Department, State University of 
      Maringa, Maringa, PR, Brazil.
FAU - Guelsin, G A S
AU  - Guelsin GAS
AD  - Research Laboratory of Molecular Blood Group, Hematology and HemotherapyCenter, 
      State University of Campinas, Campinas, SP, Brazil.
FAU - Higa, T T
AU  - Higa TT
AD  - Maringa Regional Blood Center, Maringa, PR, Brazil.
FAU - Pagliarini E Silva, S
AU  - Pagliarini E Silva S
AD  - Maringa Cancer Hospital, Maringa, PR, Brazil.
FAU - Macedo, L C
AU  - Macedo LC
AD  - Immunogenetics Laboratory, Basic Health Sciences Department, State University of 
      Maringa, Maringa, PR, Brazil.
FAU - Sippert, E A
AU  - Sippert EA
AD  - Research Laboratory of Molecular Blood Group, Hematology and HemotherapyCenter, 
      State University of Campinas, Campinas, SP, Brazil.
FAU - de Alencar, J B
AU  - de Alencar JB
AD  - Immunogenetics Laboratory, Basic Health Sciences Department, State University of 
      Maringa, Maringa, PR, Brazil.
FAU - Zanette, A
AU  - Zanette A
AD  - Bahia Hematology and HemotherapyCenter, Salvador, BA, Brazil.
FAU - Acorsi, C R L
AU  - Acorsi CRL
AD  - Department of Statistics, State University of Maringa, Maringa, PR, Brazil.
FAU - Castilho, L
AU  - Castilho L
AD  - Research Laboratory of Molecular Blood Group, Hematology and HemotherapyCenter, 
      State University of Campinas, Campinas, SP, Brazil.
FAU - Visentainer, J E L
AU  - Visentainer JEL
AD  - Immunogenetics Laboratory, Basic Health Sciences Department, State University of 
      Maringa, Maringa, PR, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20170907
PL  - England
TA  - Transfus Med
JT  - Transfusion medicine (Oxford, England)
JID - 9301182
RN  - 0 (HLA Antigens)
RN  - 0 (Isoantibodies)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Anemia, Sickle Cell/genetics/immunology/therapy
MH  - *Blood Transfusion
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - *HLA Antigens/genetics/immunology
MH  - Humans
MH  - Isoantibodies/immunology
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Risk Factors
MH  - *Transfusion Reaction/genetics/immunology
OTO - NOTNLM
OT  - blood transfusion
OT  - erythrocyte antigen alloimmunisation
OT  - human leucocyte antigen
OT  - sickle cell anaemia
EDAT- 2017/09/08 06:00
MHDA- 2018/10/26 06:00
CRDT- 2017/09/08 06:00
PHST- 2016/11/16 00:00 [received]
PHST- 2017/07/05 00:00 [revised]
PHST- 2017/08/09 00:00 [accepted]
PHST- 2017/09/08 06:00 [pubmed]
PHST- 2018/10/26 06:00 [medline]
PHST- 2017/09/08 06:00 [entrez]
AID - 10.1111/tme.12459 [doi]
PST - ppublish
SO  - Transfus Med. 2017 Dec;27(6):437-443. doi: 10.1111/tme.12459. Epub 2017 Sep 7.