PMID- 28881704
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20170925
LR  - 20200309
IS  - 1949-2553 (Electronic)
IS  - 1949-2553 (Linking)
VI  - 8
IP  - 31
DP  - 2017 Aug 1
TI  - Chaperone-mediated autophagy substrate proteins in cancer.
PG  - 51970-51985
LID - 10.18632/oncotarget.17583 [doi]
AB  - All intracellular proteins undergo continuous synthesis and degradation. 
      Chaperone-mediated autophagy (CMA) is necessary to maintain cellular homeostasis 
      through turnover of cytosolic proteins (substrate proteins). This degradation 
      involves a series of substrate proteins including both cancer promoters and 
      suppressors. Since activating or inhibiting CMA pathway to treat cancer is still 
      debated, targeting to the CMA substrate proteins provides a novel direction. We 
      summarize the cancer-associated substrate proteins which are degraded by CMA. 
      Consequently, CMA substrate proteins catalyze the glycolysis which contributes to 
      the Warburg effect in cancer cells. The fact that the degradation of substrate 
      proteins based on the CMA can be altered by posttranslational modifications such 
      as phosphorylation or acetylation. In conclusion, targeting to CMA substrate 
      proteins develops into a new anticancer therapeutic approach.
FAU - Tang, Ying
AU  - Tang Y
AD  - Department of Oncology, The First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, 
      China.
FAU - Wang, Xiong-Wen
AU  - Wang XW
AD  - Department of Oncology, The First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, 
      China.
FAU - Liu, Zhan-Hua
AU  - Liu ZH
AD  - Department of Oncology, The First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, 
      China.
FAU - Sun, Yun-Ming
AU  - Sun YM
AD  - Department of Gynecology and Obstetrics, Maternal and Child Health Hospital of 
      Zhoushan, Zhoushan 316000, China.
FAU - Tang, Yu-Xin
AU  - Tang YX
AD  - Department of Gynecology and Obstetrics, Maternal and Child Health Hospital of 
      Zhoushan, Zhoushan 316000, China.
FAU - Zhou, Dai-Han
AU  - Zhou DH
AD  - Department of Oncology, The First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, 
      China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170503
PL  - United States
TA  - Oncotarget
JT  - Oncotarget
JID - 101532965
PMC - PMC5584305
OTO - NOTNLM
OT  - Warburg effect
OT  - cancer
OT  - chaperone-mediated autophagy
OT  - glycolysis
OT  - substrate proteins
COIS- CONFLICTS OF INTEREST The authors have declared no potential conflicts of 
      interest.
EDAT- 2017/09/09 06:00
MHDA- 2017/09/09 06:01
PMCR- 2017/08/01
CRDT- 2017/09/09 06:00
PHST- 2017/01/09 00:00 [received]
PHST- 2017/04/07 00:00 [accepted]
PHST- 2017/09/09 06:00 [entrez]
PHST- 2017/09/09 06:00 [pubmed]
PHST- 2017/09/09 06:01 [medline]
PHST- 2017/08/01 00:00 [pmc-release]
AID - 17583 [pii]
AID - 10.18632/oncotarget.17583 [doi]
PST - epublish
SO  - Oncotarget. 2017 May 3;8(31):51970-51985. doi: 10.18632/oncotarget.17583. 
      eCollection 2017 Aug 1.