PMID- 28883090
OWN - NLM
STAT- Publisher
LR  - 20240227
IS  - 1468-3296 (Electronic)
IS  - 0040-6376 (Linking)
DP  - 2017 Sep 7
TI  - Validity, responsiveness and minimum clinically important difference of the 
      incremental shuttle walk in idiopathic pulmonary fibrosis: a prospective study.
LID - thoraxjnl-2017-210589 [pii]
LID - 10.1136/thoraxjnl-2017-210589 [doi]
AB  - The incremental shuttle walk (ISW) is well validated in COPD but limited 
      psychometric data restrict its use in idiopathic pulmonary fibrosis (IPF). Study 
      1: 50 patients performed the ISW and 6 min walk test (6MWT). Study 2: 72 patients 
      completed the ISW before and after pulmonary rehabilitation (PR). The ISW 
      correlated strongly with 6MWT distance (r=0.81,p<0.0001). Mean (95% confidence 
      interval) improvement in ISW with PR was 54 (38 to 70) m with an effect size of 
      0.29. Distribution-based and anchor-based minimum clinically important difference 
      (MCID) estimates ranged from 31 to 46 m. The ISW is valid and responsive in IPF, 
      with an anchor-based MCID estimate similar to that observed in chronic 
      obstructive pulmonary disease. TRIAL REGISTRATION NUMBER: Pre-results; 
      NCT02530736, NCT02436278.
CI  - (c) Article author(s) (or their employer(s) unless otherwise stated in the text of 
      the article) 2017. All rights reserved. No commercial use is permitted unless 
      otherwise expressly granted.
FAU - Nolan, Claire M
AU  - Nolan CM
AD  - Harefield Pulmonary Rehabilitation and Muscle Research Laboratory, Harefield 
      Hospital, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK.
AD  - National Heart and Lung Institute, Imperial College, London, UK.
FAU - Delogu, Veronica
AU  - Delogu V
AD  - Harefield Pulmonary Rehabilitation and Muscle Research Laboratory, Harefield 
      Hospital, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK.
FAU - Maddocks, Matthew
AU  - Maddocks M
AD  - Cicely Saunders Institute of Palliative Care, Policy and Rehabilitation, King's 
      College London, London, UK.
FAU - Patel, Suhani
AU  - Patel S
AD  - Harefield Pulmonary Rehabilitation and Muscle Research Laboratory, Harefield 
      Hospital, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK.
FAU - Barker, Ruth E
AU  - Barker RE
AD  - Harefield Pulmonary Rehabilitation and Muscle Research Laboratory, Harefield 
      Hospital, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK.
FAU - Jones, Sarah E
AU  - Jones SE
AD  - Harefield Pulmonary Rehabilitation and Muscle Research Laboratory, Harefield 
      Hospital, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK.
FAU - Kon, Samantha S C
AU  - Kon SSC
AD  - Harefield Pulmonary Rehabilitation and Muscle Research Laboratory, Harefield 
      Hospital, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK.
AD  - Department of Respiratory Medicine, The Hillingdon Hospitals NHS Foundation 
      Trust, London, UK.
FAU - Maher, Toby M
AU  - Maher TM
AUID- ORCID: 0000-0001-7192-9149
AD  - National Heart and Lung Institute, Imperial College, London, UK.
AD  - Department of Interstitial Lung Disease Unit, Royal Brompton and Harefield NHS 
      Foundation Trust, London, UK.
FAU - Cullinan, Paul
AU  - Cullinan P
AD  - National Heart and Lung Institute, Imperial College, London, UK.
FAU - Man, William D-C
AU  - Man WD
AD  - Harefield Pulmonary Rehabilitation and Muscle Research Laboratory, Harefield 
      Hospital, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK.
AD  - National Heart and Lung Institute, Imperial College, London, UK.
LA  - eng
SI  - ClinicalTrials.gov/NCT02530736
SI  - ClinicalTrials.gov/NCT02436278
GR  - CTF-01-12-04/DH_/Department of Health/United Kingdom
GR  - DHCS/07/07/009/DH_/Department of Health/United Kingdom
GR  - PB-PG-0213-30003/DH_/Department of Health/United Kingdom
GR  - DRF-2014-07-089/DH_/Department of Health/United Kingdom
GR  - CDF-2017-10-009/DH_/Department of Health/United Kingdom
PT  - Journal Article
DEP - 20170907
PL  - England
TA  - Thorax
JT  - Thorax
JID - 0417353
OTO - NOTNLM
OT  - IPF
OT  - incremental shuttle walk test
COIS- Competing interests: VD, SP and REB are funded by the NIHR Respiratory Biomedical 
      Research Unit, Royal Brompton and Harefield NHS Foundation Trust and Imperial 
      College. VD is funded by NIHR Collaboration for Leadership in Applied Health 
      Research and Care (CLAHRC) for Northwest London. MM is supported by Cicely 
      Saunders International and CLAHRC for South London. SSCK is funded by The 
      Hillingdon Hospital and The Royal Brompton and Harefield NHS Foundation Trust. 
      TMM is supported by an NIHR Clinician Scientist Fellowship (NIHR Ref: 
      CS-2013-13-017). WDCM is partly funded by the NIHR CLAHRC for NW London. The 
      views expressed in this publication are those of the authors and not necessarily 
      those of the NHS, the NIHR or the Department of Health. All other author have no 
      competing interest to declare.
EDAT- 2017/09/09 06:00
MHDA- 2017/09/09 06:00
CRDT- 2017/09/09 06:00
PHST- 2017/05/30 00:00 [received]
PHST- 2017/08/11 00:00 [revised]
PHST- 2017/08/29 00:00 [accepted]
PHST- 2017/09/09 06:00 [entrez]
PHST- 2017/09/09 06:00 [pubmed]
PHST- 2017/09/09 06:00 [medline]
AID - thoraxjnl-2017-210589 [pii]
AID - 10.1136/thoraxjnl-2017-210589 [doi]
PST - aheadofprint
SO  - Thorax. 2017 Sep 7:thoraxjnl-2017-210589. doi: 10.1136/thoraxjnl-2017-210589.