PMID- 28885451
OWN - NLM
STAT- MEDLINE
DCOM- 20200331
LR  - 20230825
IS  - 1536-5166 (Electronic)
IS  - 1070-8022 (Linking)
VI  - 38
IP  - 3
DP  - 2018 Sep
TI  - Visual Structure and Function in Collision Sport Athletes.
PG  - 285-291
LID - 10.1097/WNO.0000000000000572 [doi]
AB  - BACKGROUND: Vision-based measures have been shown to be useful markers in 
      multiple sclerosis (MS), Alzheimer and Parkinson disease. Therefore, these 
      testing paradigms may have applications to populations explaining repetitive head 
      trauma that has been associated with long-term neurodegenerative sequelae. We 
      investigated retinal structure and visual function in professional collision 
      sport athletes compared to age- and race-matched control participants. METHODS: 
      In this cross-sectional study, participants underwent spectral-domain optical 
      coherence tomography (OCT) measurements of peripapillary retinal nerve fiber 
      layer (RNFL) and macular ganglion cell complex (GCC = ganglion cell + inner 
      plexiform layers) thickness. High-contrast visual acuity (100% level), 
      low-contrast letter acuity (LCLA) (1.25% and 2.5% levels), and King-Devick Test 
      of rapid number naming performance were administered. Vision-specific quality of 
      life (QOL) measures were assessed. RESULTS: Among 46 collision sport athletes 
      (boxing, n = 14; football, n = 29; ice hockey, n = 3) and 104 control 
      participants, average RNFL thickness was a significant predictor of athlete vs 
      control status with athletes demonstrating 4.8-mum of thinning compared to 
      controls (P = 0.01, generalized estimating equation [GEE] models accounting for 
      age and within-subject, intereye correlations). Athlete vs control status was not 
      a predictor of RNFL thickness for the subgroup of football players in this cohort 
      (P = 0.60). Binocular (P = 0.001) and monocular (P = 0.02) LCLA at 2.5% contrast 
      and vision-specific QOL (P = 0.04) were significant predictors of athlete vs 
      control status (GEE models accounting for age and within-subject, intereye 
      correlations). Rapid number naming performance times were not significantly 
      different between the control and athlete groups. CONCLUSIONS: This study showed 
      that retinal axonal and neuronal loss is present among collision sport athletes, 
      with most notable differences seen in boxers. These findings are accompanied by 
      reductions in visual function and QOL, similar to patterns observed in multiple 
      sclerosis, Alzheimer and Parkinson diseases. Vision-based changes associated with 
      head trauma exposure that have the potential to be detected in vivo represent a 
      unique opportunity for further study to determine if these changes in collision 
      sport athletes are predictive of future neurodegeneration.
FAU - Leong, Danielle
AU  - Leong D
AD  - Illinois Eye Institute (DL, CM, LVM, RJS, YP), Illinois College of Optometry, 
      Chicago, Illinois; and Departments of Neurology, Ophthalmology, Population Health 
      (SLG, LJB), New York University, New York, New York.
FAU - Morettin, Christina
AU  - Morettin C
FAU - Messner, Leonard V
AU  - Messner LV
FAU - Steinmetz, Robert J
AU  - Steinmetz RJ
FAU - Pang, Yi
AU  - Pang Y
FAU - Galetta, Steven L
AU  - Galetta SL
FAU - Balcer, Laura J
AU  - Balcer LJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neuroophthalmol
JT  - Journal of neuro-ophthalmology : the official journal of the North American 
      Neuro-Ophthalmology Society
JID - 9431308
SB  - IM
CIN - Eye (Lond). 2023 Aug;37(12):2385-2390. PMID: 36801966
MH  - Adult
MH  - *Athletes
MH  - Athletic Injuries/*complications/diagnosis
MH  - Brain Concussion/*complications/diagnosis
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retinal Diseases/*diagnosis/etiology
MH  - Retinal Ganglion Cells/*pathology
MH  - Tomography, Optical Coherence/*methods
MH  - *Visual Acuity
EDAT- 2017/09/09 06:00
MHDA- 2020/04/01 06:00
CRDT- 2017/09/09 06:00
PHST- 2017/09/09 06:00 [pubmed]
PHST- 2020/04/01 06:00 [medline]
PHST- 2017/09/09 06:00 [entrez]
AID - 10.1097/WNO.0000000000000572 [doi]
PST - ppublish
SO  - J Neuroophthalmol. 2018 Sep;38(3):285-291. doi: 10.1097/WNO.0000000000000572.