PMID- 28886321
OWN - NLM
STAT- MEDLINE
DCOM- 20180515
LR  - 20181023
IS  - 1165-158X (Electronic)
IS  - 0145-5680 (Linking)
VI  - 63
IP  - 8
DP  - 2017 Aug 30
TI  - Relationship between MCP1 (-2518A>G) gene variants and ovarian cancer in Turkish 
      population.
PG  - 100-103
LID - 10.14715/cmb/2017.63.8.21 [doi]
AB  - The monocyte chemoattractant protein-1 (MCP-1) gene polymorphism(-2518A>G)  in 
      the regulatory region of the MCP-1 protein has been reported to be associated 
      with cancer risk. In this study we aimed to investigate the relationship of MCP-1 
      (-2518A>G) gene polymorphism and ovarian cancer. MCP-1 genotyping was 
      performed using polymerase chain reaction from blood samples ofovarian cancer 
      patient (n=56) and a control groups (n=52).There was a significant difference in 
      MCP1 (-2518A>G) genotypes between the patient and control groups (p=0.049; 
      x2=6.042). AA carriers were significantly higher in the control group (p=0.014) 
      whereas AG genotype and G allele carriers were significantly higher in the 
      ovarian cancer group (p=0.029, p=0.014, respectively). This study suggests that 
      MCP-1 (-2518A>G) AG genotype and G allele could be considered as risk factor 
      for susceptibility to ovarian cancer.
FAU - Attar, R
AU  - Attar R
AD  - Department of Obstetrics and Gynecology, Faculty of Medicine, Yeditepe 
      University, Istanbul, Turkey.
FAU - Yilmaz, S G
AU  - Yilmaz SG
AD  - Department of Molecular Medicine, Institute of Health Sciences, Yeditepe 
      University, Istanbul, Turkey.
FAU - Cakmakoglu, B
AU  - Cakmakoglu B
AD  - Department of Molecular Medicine, ASDETAE, Istanbul University, Istanbul, Turkey.
FAU - Duman, S
AU  - Duman S
AD  - Department of Molecular Medicine, Institute of Health Sciences, Yeditepe 
      University, Istanbul, Turkey.
FAU - Yildirim, G
AU  - Yildirim G
AD  - Department of Obstetrics and Gynecology, Faculty of Medicine, Yeditepe 
      University, Istanbul, Turkey.
FAU - Gormus, U
AU  - Gormus U
AD  - Department of Medical Genetics, Faculty of Medicine, Istinye University, Istinye 
      University.
FAU - Isbir, T
AU  - Isbir T
AD  - Department of Medical Biology, Faculty of Medicine, Yeditepe University, 
      Istanbul, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20170830
PL  - France
TA  - Cell Mol Biol (Noisy-le-grand)
JT  - Cellular and molecular biology (Noisy-le-Grand, France)
JID - 9216789
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Alleles
MH  - Case-Control Studies
MH  - Chemokine CCL2/*genetics
MH  - Female
MH  - Gene Expression
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Ovarian Neoplasms/diagnosis/*genetics/pathology
MH  - *Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic
MH  - Risk Factors
MH  - Turkey
OTO - NOTNLM
OT  - Case-control study
OT  - Genetic variability
OT  - MCP1 (-2518A>G)
OT  - Ovarian cancer.
OT  - Single nucleotide polymorphism
EDAT- 2017/09/09 06:00
MHDA- 2018/05/16 06:00
CRDT- 2017/09/09 06:00
PHST- 2017/04/14 00:00 [received]
PHST- 2017/07/19 00:00 [accepted]
PHST- 2017/06/15 00:00 [revised]
PHST- 2017/09/09 06:00 [entrez]
PHST- 2017/09/09 06:00 [pubmed]
PHST- 2018/05/16 06:00 [medline]
AID - 10.14715/cmb/2017.63.8.21 [doi]
PST - epublish
SO  - Cell Mol Biol (Noisy-le-grand). 2017 Aug 30;63(8):100-103. doi: 
      10.14715/cmb/2017.63.8.21.