PMID- 28886425
OWN - NLM
STAT- MEDLINE
DCOM- 20180131
LR  - 20180131
IS  - 1872-7077 (Electronic)
IS  - 1382-6689 (Linking)
VI  - 56
DP  - 2017 Dec
TI  - Enhanced thymocyte apoptosis induced by maternal undernutrition in late gestation 
      results in declined mature T cells in rat fetal thymus.
PG  - 50-55
LID - S1382-6689(17)30238-7 [pii]
LID - 10.1016/j.etap.2017.08.018 [doi]
AB  - This study was designed to observe the effects of maternal food restriction (MFR) 
      on the development of fetal thymus in different gestation periods. Timed pregnant 
      rats were randomized into 3 groups: CN (free access to standard chow throughout 
      gestation), MFR(0-21) (50% MFR throughout gestation), MFR(0-14) (50% MFR from 
      gestational day (GD) 0 to GD14, early-mid gestation). Results showed that MFR 
      during early-mid period had few impact on the fetal thymus and T cell 
      subpopulations. However, MFR throughout gestation resulted in thymic atrophy, 
      deceased frequency of both CD4(+) and CD8(+) single positive (SP) T cells and 
      enhanced thymocyte apoptosis in fetus. Our results suggest the fetal thymus is 
      more vulnerable to the adverse intrauterine environments in the late gestation 
      period, and the decreased number of SP T cells could result from the enhanced 
      thymocyte apoptosis.
CI  - Copyright (c) 2017. Published by Elsevier B.V.
FAU - Qu, Wen
AU  - Qu W
AD  - Department of Pharmacology, Wuhan University School of Basic Medical Sciences, 
      Wuhan 430071, China; Hubei Provincial Center for Disease Control and Prevention, 
      Wuhan 430079, China. Electronic address: 18802714142@163.com.
FAU - Ma, Liang-Peng
AU  - Ma LP
AD  - Department of Pharmacy, Wuhan First Hospital, Wuhan 430022, China. Electronic 
      address: 176051469@qq.com.
FAU - Yan, Hui-Yi
AU  - Yan HY
AD  - Department of Pharmacology, Wuhan University School of Basic Medical Sciences, 
      Wuhan 430071, China.
FAU - Liu, Sha
AU  - Liu S
AD  - Department of Pharmacology, Wuhan University School of Basic Medical Sciences, 
      Wuhan 430071, China.
FAU - Liu, Han-Xiao
AU  - Liu HX
AD  - Department of Pharmacology, Wuhan University School of Basic Medical Sciences, 
      Wuhan 430071, China.
FAU - Chen, Ting
AU  - Chen T
AD  - Department of Pharmacology, Wuhan University School of Basic Medical Sciences, 
      Wuhan 430071, China.
FAU - Hou, Li-Fang
AU  - Hou LF
AD  - Department of Pharmacology, Wuhan University School of Basic Medical Sciences, 
      Wuhan 430071, China.
FAU - Ping, Jie
AU  - Ping J
AD  - Department of Pharmacology, Wuhan University School of Basic Medical Sciences, 
      Wuhan 430071, China. Electronic address: pingjie@whu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20170824
PL  - Netherlands
TA  - Environ Toxicol Pharmacol
JT  - Environmental toxicology and pharmacology
JID - 9612020
SB  - IM
MH  - Animals
MH  - Apoptosis
MH  - CD4-Positive T-Lymphocytes/cytology
MH  - CD8-Positive T-Lymphocytes/cytology
MH  - Female
MH  - Gestational Age
MH  - Lymphocyte Count
MH  - Malnutrition/*complications/immunology
MH  - Maternal-Fetal Exchange
MH  - Pregnancy
MH  - Rats
MH  - Rats, Wistar
MH  - T-Lymphocytes/*cytology
MH  - Thymocytes/*cytology
MH  - Thymus Gland/*immunology
OTO - NOTNLM
OT  - Apoptosis
OT  - Food restriction
OT  - IUGR
OT  - T cells
OT  - Thymus
EDAT- 2017/09/09 06:00
MHDA- 2018/02/01 06:00
CRDT- 2017/09/09 06:00
PHST- 2017/07/10 00:00 [received]
PHST- 2017/08/17 00:00 [revised]
PHST- 2017/08/18 00:00 [accepted]
PHST- 2017/09/09 06:00 [pubmed]
PHST- 2018/02/01 06:00 [medline]
PHST- 2017/09/09 06:00 [entrez]
AID - S1382-6689(17)30238-7 [pii]
AID - 10.1016/j.etap.2017.08.018 [doi]
PST - ppublish
SO  - Environ Toxicol Pharmacol. 2017 Dec;56:50-55. doi: 10.1016/j.etap.2017.08.018. 
      Epub 2017 Aug 24.