PMID- 28886901
OWN - NLM
STAT- MEDLINE
DCOM- 20180605
LR  - 20240213
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Print)
IS  - 0165-1781 (Linking)
VI  - 258
DP  - 2017 Dec
TI  - Perceptual abnormalities in clinical high risk youth and the role of trauma, 
      cannabis use and anxiety.
PG  - 462-468
LID - S0165-1781(17)30315-3 [pii]
LID - 10.1016/j.psychres.2017.08.045 [doi]
AB  - Recent research suggests that perceptual abnormalities are a group of diverse 
      experiences, which have been associated with trauma, cannabis use, and anxiety. 
      Of the attenuated psychotic symptoms that are present in youth at clinical high 
      risk (CHR) of psychosis, perceptual abnormalities tend to be one of the most 
      frequently endorsed symptoms. However, very few studies have explored perceptual 
      abnormalities and their relationships with the above environmental and affective 
      factors in a CHR sample. Four hundred and forty-one CHR individuals who met 
      criteria for attenuated psychotic symptom syndrome (APSS) determined by the 
      Structured Interview for Psychosis-risk Syndromes (SIPS) were assessed on the 
      content of their perceptual abnormalities, early traumatic experience, cannabis 
      use and self-reported anxiety. Logistic regression analyses suggested that both 
      simple auditory and simple visual perceptual abnormalities were more likely to be 
      reported by CHR who had early traumatic experiences, who are current cannabis 
      users, and who have higher levels of anxiety. Multiple regression analysis 
      revealed that only trauma and anxiety were independent predictors of both simple 
      auditory and simple visual perceptual abnormalities. It is possible that 
      examining subtypes of perceptual abnormalities in CHR leads to an improved 
      understanding of the prevalence of such symptoms.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Lu, Yun
AU  - Lu Y
AD  - Hotchkiss Brain Institute, Department of Psychiatry, University of Calgary, 
      Calgary, Alberta, Canada.
FAU - Marshall, Catherine
AU  - Marshall C
AD  - Hotchkiss Brain Institute, Department of Psychiatry, University of Calgary, 
      Calgary, Alberta, Canada.
FAU - Cadenhead, Kristin S
AU  - Cadenhead KS
AD  - Department of Psychiatry, University of California at San Diego, La Jolla, CA, 
      USA.
FAU - Cannon, Tyrone D
AU  - Cannon TD
AD  - Department of Psychology, Yale University, New Haven, CT, USA.
FAU - Cornblatt, Barbara A
AU  - Cornblatt BA
AD  - Department of Psychiatry, Zucker Hillside Hospital, Long Island, NY, USA.
FAU - McGlashan, Thomas H
AU  - McGlashan TH
AD  - Department of Psychiatry, Yale University, New Haven, CT, USA.
FAU - Perkins, Diana O
AU  - Perkins DO
AD  - Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA.
FAU - Seidman, Larry J
AU  - Seidman LJ
AD  - Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
FAU - Tsuang, Ming T
AU  - Tsuang MT
AD  - Department of Psychiatry, University of California at San Diego, La Jolla, CA, 
      USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
FAU - Walker, Elaine F
AU  - Walker EF
AD  - Departments of Psychology and Psychiatry, Emory University, Atlanta, GA, USA.
FAU - Woods, Scott W
AU  - Woods SW
AD  - Department of Psychiatry, Yale University, New Haven, CT, USA.
FAU - Bearden, Carrie E
AU  - Bearden CE
AD  - Department of Psychiatry & Biobehavioral Sciences and Psychology University of 
      California at Los Angeles, Los Angeles, CA, USA.
FAU - Mathalon, Daniel
AU  - Mathalon D
AD  - Department of Psychiatry, University of California at San Francisco and SFVA 
      Medical Center, San Francisco, CA, USA.
FAU - Addington, Jean
AU  - Addington J
AD  - Hotchkiss Brain Institute, Department of Psychiatry, University of Calgary, 
      Calgary, Alberta, Canada. Electronic address: jmadding@ucalgary.ca.
LA  - eng
GR  - U01 MH081902/MH/NIMH NIH HHS/United States
GR  - P50 MH080272/MH/NIMH NIH HHS/United States
GR  - U01 MH081988/MH/NIMH NIH HHS/United States
GR  - P50 MH066286/MH/NIMH NIH HHS/United States
GR  - K24 MH076191/MH/NIMH NIH HHS/United States
GR  - U01 MH082022/MH/NIMH NIH HHS/United States
GR  - U01 MH081984/MH/NIMH NIH HHS/United States
GR  - R01 MH060720/MH/NIMH NIH HHS/United States
GR  - U01 MH081928/MH/NIMH NIH HHS/United States
GR  - U01 MH081857/MH/NIMH NIH HHS/United States
GR  - U01 MH082004/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20170831
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
SB  - IM
MH  - Adolescent
MH  - Anxiety/*psychology
MH  - Anxiety Disorders/psychology
MH  - Female
MH  - Humans
MH  - Male
MH  - Marijuana Use/*psychology
MH  - Prevalence
MH  - Psychotic Disorders/*psychology
MH  - Risk
MH  - Self Report
MH  - Syndrome
PMC - PMC5915322
MID - NIHMS904429
OTO - NOTNLM
OT  - Attenuated psychotic symptoms
OT  - Clinical high risk
OT  - Hallucinations
OT  - Perceptual abnormalities
EDAT- 2017/09/10 06:00
MHDA- 2018/06/06 06:00
PMCR- 2018/12/01
CRDT- 2017/09/10 06:00
PHST- 2017/02/24 00:00 [received]
PHST- 2017/07/12 00:00 [revised]
PHST- 2017/08/18 00:00 [accepted]
PHST- 2017/09/10 06:00 [pubmed]
PHST- 2018/06/06 06:00 [medline]
PHST- 2017/09/10 06:00 [entrez]
PHST- 2018/12/01 00:00 [pmc-release]
AID - S0165-1781(17)30315-3 [pii]
AID - 10.1016/j.psychres.2017.08.045 [doi]
PST - ppublish
SO  - Psychiatry Res. 2017 Dec;258:462-468. doi: 10.1016/j.psychres.2017.08.045. Epub 
      2017 Aug 31.