PMID- 28886990
OWN - NLM
STAT- MEDLINE
DCOM- 20180606
LR  - 20221207
IS  - 1873-460X (Electronic)
IS  - 1056-8727 (Linking)
VI  - 31
IP  - 11
DP  - 2017 Nov
TI  - Comparison of traditional diabetes risk scores and HbA1c to predict type 2 
      diabetes mellitus in a population based cohort study.
PG  - 1602-1607
LID - S1056-8727(17)30710-9 [pii]
LID - 10.1016/j.jdiacomp.2017.07.016 [doi]
AB  - AIMS: Compare performances of diabetes risk scores and glycated hemoglobin 
      (HbA1c) to estimate the risk of incident type 2 diabetes mellitus (T2DM) in 
      Northeast Germany. METHODS: We studied 2916 subjects (20 to 81years) from the 
      Study of Health in Pomerania (SHIP) in a 5-year follow-up period. Diabetes risk 
      scores included the Cooperative Health Research in the Region of Augsburg (KORA) 
      base model, the Danish diabetes risk score and the Data from the Epidemiological 
      Study on the Insulin Resistance syndrome (D.E.S.I.R) clinical risk score. We 
      assessed the performance of each of the diabetes risk scores and the HbA1c for 
      5-year risk of T2DM by the area under the receiver-operating characteristic curve 
      (AUC) and calibration plots. RESULTS: In SHIP, the incidence of T2DM was 5.4% 
      (n=157) in the 5-year follow-up period. Diabetes risk scores and HbA1c achieved 
      AUCs ranging from 0.76 for the D.E.S.I.R. clinical risk score to 0.82 for the 
      KORA base model. For diabetes risk scores, the discriminative ability was lower 
      for the age group 55 to 74years. For HbA1c, the discriminative ability also 
      decreased for the group 55 to 74years while it was stable in the age group 30 to 
      64years old. CONCLUSIONS: All diabetes risk scores and the HbA1c showed a good 
      prediction for the risk of T2DM in SHIP. Which model or biomarker should be used 
      is driven by its context of use, e.g. the practicability, implementation of 
      interventions and availability of measurement.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Krabbe, Christine Emma Maria
AU  - Krabbe CEM
AD  - Department of Study of Health in Pomerania/Clinical-Epidemiological Research, 
      Institute for Community Medicine, University Medicine Greifswald, Greifswald, 
      Germany.
FAU - Schipf, Sabine
AU  - Schipf S
AD  - Department of Study of Health in Pomerania/Clinical-Epidemiological Research, 
      Institute for Community Medicine, University Medicine Greifswald, Greifswald, 
      Germany; German Center for Diabetes Research (DZD), partner site Greifswald, 
      Greifswald, Germany.
FAU - Ittermann, Till
AU  - Ittermann T
AD  - Department of Study of Health in Pomerania/Clinical-Epidemiological Research, 
      Institute for Community Medicine, University Medicine Greifswald, Greifswald, 
      Germany.
FAU - Dorr, Marcus
AU  - Dorr M
AD  - Department of Internal Medicine B, University Medicine Greifswald, Greifswald, 
      Germany; German Centre for Cardiovascular Research (DZHK), partner site 
      Greifswald, Greifswald, Germany.
FAU - Nauck, Matthias
AU  - Nauck M
AD  - German Centre for Cardiovascular Research (DZHK), partner site Greifswald, 
      Greifswald, Germany; Institute of Clinical Chemistry and Laboratory Medicine, 
      University Medicine Greifswald, Greifswald, Germany.
FAU - Chenot, Jean-Francois
AU  - Chenot JF
AD  - Department of General Practice, Institute for Community Medicine, University 
      Medicine Greifswald, Greifswald, Germany.
FAU - Markus, Marcello Ricardo Paulista
AU  - Markus MRP
AD  - Department of Study of Health in Pomerania/Clinical-Epidemiological Research, 
      Institute for Community Medicine, University Medicine Greifswald, Greifswald, 
      Germany; German Center for Diabetes Research (DZD), partner site Greifswald, 
      Greifswald, Germany; Department of Internal Medicine B, University Medicine 
      Greifswald, Greifswald, Germany; German Centre for Cardiovascular Research 
      (DZHK), partner site Greifswald, Greifswald, Germany. Electronic address: 
      marcello.markus@uni-greifswald.de.
FAU - Volzke, Henry
AU  - Volzke H
AD  - Department of Study of Health in Pomerania/Clinical-Epidemiological Research, 
      Institute for Community Medicine, University Medicine Greifswald, Greifswald, 
      Germany; German Centre for Cardiovascular Research (DZHK), partner site 
      Greifswald, Greifswald, Germany.
LA  - eng
PT  - Journal Article
PT  - Validation Study
DEP - 20170801
PL  - United States
TA  - J Diabetes Complications
JT  - Journal of diabetes and its complications
JID - 9204583
RN  - 0 (Biomarkers)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/blood/*diagnosis/epidemiology
MH  - Female
MH  - Follow-Up Studies
MH  - Germany/epidemiology
MH  - Glycated Hemoglobin/*analysis
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Mass Screening/*methods
MH  - Middle Aged
MH  - *Practice Guidelines as Topic
MH  - Predictive Value of Tests
MH  - Prevalence
MH  - Risk Factors
MH  - Sensitivity and Specificity
MH  - Young Adult
OTO - NOTNLM
OT  - Epidemiology
OT  - Health care delivery
OT  - Prediction of diabetes
OT  - Prevention of diabetes
OT  - Screening
EDAT- 2017/09/10 06:00
MHDA- 2018/06/07 06:00
CRDT- 2017/09/10 06:00
PHST- 2017/05/16 00:00 [received]
PHST- 2017/07/24 00:00 [revised]
PHST- 2017/07/27 00:00 [accepted]
PHST- 2017/09/10 06:00 [pubmed]
PHST- 2018/06/07 06:00 [medline]
PHST- 2017/09/10 06:00 [entrez]
AID - S1056-8727(17)30710-9 [pii]
AID - 10.1016/j.jdiacomp.2017.07.016 [doi]
PST - ppublish
SO  - J Diabetes Complications. 2017 Nov;31(11):1602-1607. doi: 
      10.1016/j.jdiacomp.2017.07.016. Epub 2017 Aug 1.