PMID- 28887135
OWN - NLM
STAT- MEDLINE
DCOM- 20180725
LR  - 20180725
IS  - 1873-4995 (Electronic)
IS  - 0168-3659 (Linking)
VI  - 268
DP  - 2017 Dec 28
TI  - Progress in brain targeting drug delivery system by nasal route.
PG  - 364-389
LID - S0168-3659(17)30825-8 [pii]
LID - 10.1016/j.jconrel.2017.09.001 [doi]
AB  - The blood-brain barrier (BBB) restricts the transport of potential therapeutic 
      moieties to the brain. Direct targeting the brain via olfactory and trigeminal 
      neural pathways by passing the BBB has gained an important consideration for 
      delivery of wide range of therapeutics to brain. Intranasal route of 
      transportation directly delivers the drugs to brain without systemic absorption, 
      thus avoiding the side effects and enhancing the efficacy of neurotherapeutics. 
      Over the last several decades, different drug delivery systems (DDSs) have been 
      studied for targeting the brain by the nasal route. Novel DDSs such as 
      nanoparticles (NPs), liposomes and polymeric micelles have gained potential as 
      useful tools for targeting the brain without toxicity in nasal mucosa and central 
      nervous system (CNS). Complex geometry of the nasal cavity presented a big 
      challenge to effective delivery of drugs beyond the nasal valve. Recently, 
      pharmaceutical firms utilized latest and emerging nasal drug delivery 
      technologies to overcome these barriers. This review aims to describe the latest 
      development of brain targeted DDSs via nasal administration. CHEMICAL COMPOUNDS 
      STUDIED IN THIS ARTICLE: Carbopol 934p (PubChem CID: 6581) Carboxy 
      methylcellulose (PubChem CID: 24748) Penetratin (PubChem CID: 101111470) Poly 
      lactic-co-glycolic acid (PubChem CID: 23111554) Tween 80 (PubChem CID: 5284448).
CI  - Copyright (c) 2017. Published by Elsevier B.V.
FAU - Khan, Abdur Rauf
AU  - Khan AR
AD  - Department of Pharmaceutics, College of Pharmacy, Shandong University, 44 Wenhua 
      Xilu, Jinan 250012, China.
FAU - Liu, Mengrui
AU  - Liu M
AD  - Department of Pharmaceutics, College of Pharmacy, Shandong University, 44 Wenhua 
      Xilu, Jinan 250012, China.
FAU - Khan, Muhammad Wasim
AU  - Khan MW
AD  - Department of Pharmaceutics, College of Pharmacy, Shandong University, 44 Wenhua 
      Xilu, Jinan 250012, China.
FAU - Zhai, Guangxi
AU  - Zhai G
AD  - Department of Pharmaceutics, College of Pharmacy, Shandong University, 44 Wenhua 
      Xilu, Jinan 250012, China. Electronic address: zkyjd@sdu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170906
PL  - Netherlands
TA  - J Control Release
JT  - Journal of controlled release : official journal of the Controlled Release 
      Society
JID - 8607908
SB  - IM
MH  - *Administration, Intranasal
MH  - Animals
MH  - Brain/*metabolism
MH  - *Drug Delivery Systems
MH  - Humans
OTO - NOTNLM
OT  - Blood-brain barrier
OT  - Intranasal delivery
OT  - Liposomes
OT  - Nanoparticles
OT  - Polymeric micelles
EDAT- 2017/09/10 06:00
MHDA- 2018/07/26 06:00
CRDT- 2017/09/10 06:00
PHST- 2017/05/03 00:00 [received]
PHST- 2017/08/31 00:00 [revised]
PHST- 2017/09/01 00:00 [accepted]
PHST- 2017/09/10 06:00 [pubmed]
PHST- 2018/07/26 06:00 [medline]
PHST- 2017/09/10 06:00 [entrez]
AID - S0168-3659(17)30825-8 [pii]
AID - 10.1016/j.jconrel.2017.09.001 [doi]
PST - ppublish
SO  - J Control Release. 2017 Dec 28;268:364-389. doi: 10.1016/j.jconrel.2017.09.001. 
      Epub 2017 Sep 6.