PMID- 28887447
OWN - NLM
STAT- MEDLINE
DCOM- 20180129
LR  - 20181113
IS  - 2041-1723 (Electronic)
IS  - 2041-1723 (Linking)
VI  - 8
IP  - 1
DP  - 2017 Sep 8
TI  - interleukin-11 induces and maintains progenitors of different cell lineages 
      during Xenopus tadpole tail regeneration.
PG  - 495
LID - 10.1038/s41467-017-00594-5 [doi]
LID - 495
AB  - Unlike mammals, Xenopus laevis tadpoles possess high ability to regenerate their 
      lost organs. In amphibians, the main source of regenerated tissues is 
      lineage-restricted tissue stem cells, but the mechanisms underlying induction, 
      maintenance and differentiation of these stem/progenitor cells in the 
      regenerating organs are poorly understood. We previously reported that 
      interleukin-11 (il-11) is highly expressed in the proliferating cells of 
      regenerating Xenopus tadpole tails. Here, we show that il-11 knockdown (KD) 
      shortens the regenerated tail length, and the phenotype is rescued by 
      forced-il-11-expression in the KD tadpoles. Moreover, marker genes for 
      undifferentiated notochord, muscle, and sensory neurons are downregulated in the 
      KD tadpoles, and the forced-il-11-expression in intact tadpole tails induces 
      expression of these marker genes. Our findings demonstrate that il-11 is 
      necessary for organ regeneration, and suggest that IL-11 plays a key role in the 
      induction and maintenance of undifferentiated progenitors across cell lineages 
      during Xenopus tail regeneration. Xenopus laevis tadpoles have maintained their 
      ability to regenerate various organs. Here, the authors show that interleukin-11 
      is necessary for organ regeneration, by inducing and maintaining undifferentiated 
      progenitors across cell lineages during Xenopus tail regeneration.
FAU - Tsujioka, Hiroshi
AU  - Tsujioka H
AUID- ORCID: 0000-0001-7484-4191
AD  - Department of Biological Sciences, Graduate School of Science, The University of 
      Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
FAU - Kunieda, Takekazu
AU  - Kunieda T
AUID- ORCID: 0000-0002-6256-1335
AD  - Department of Biological Sciences, Graduate School of Science, The University of 
      Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
FAU - Katou, Yuki
AU  - Katou Y
AD  - Insutitute of Molecular and Cellular Biosciences, the University of Tokyo, 1-1-1, 
      Yayoi, Bunkyo-ku, Tokyo, 113-0032, Japan.
FAU - Shirahige, Katsuhiko
AU  - Shirahige K
AD  - Insutitute of Molecular and Cellular Biosciences, the University of Tokyo, 1-1-1, 
      Yayoi, Bunkyo-ku, Tokyo, 113-0032, Japan.
FAU - Fukazawa, Taro
AU  - Fukazawa T
AUID- ORCID: 0000-0003-1380-4924
AD  - Department of Biological Sciences, Graduate School of Science, The University of 
      Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. 
      tfukazawa@bs.s.u-tokyo.ac.jp.
FAU - Kubo, Takeo
AU  - Kubo T
AD  - Department of Biological Sciences, Graduate School of Science, The University of 
      Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170908
PL  - England
TA  - Nat Commun
JT  - Nature communications
JID - 101528555
RN  - 0 (Genetic Markers)
RN  - 0 (Interleukin-11)
SB  - IM
MH  - Animals
MH  - Cell Differentiation
MH  - Cell Line
MH  - Gene Expression Regulation, Developmental
MH  - Gene Knockdown Techniques
MH  - Genetic Markers
MH  - Interleukin-11/genetics/metabolism/*physiology
MH  - *Regeneration
MH  - Tail/cytology/*physiology
MH  - Xenopus
PMC - PMC5591189
COIS- The authors declare no competing financial interests.
EDAT- 2017/09/10 06:00
MHDA- 2018/01/30 06:00
PMCR- 2017/09/08
CRDT- 2017/09/10 06:00
PHST- 2016/11/01 00:00 [received]
PHST- 2017/07/10 00:00 [accepted]
PHST- 2017/09/10 06:00 [entrez]
PHST- 2017/09/10 06:00 [pubmed]
PHST- 2018/01/30 06:00 [medline]
PHST- 2017/09/08 00:00 [pmc-release]
AID - 10.1038/s41467-017-00594-5 [pii]
AID - 594 [pii]
AID - 10.1038/s41467-017-00594-5 [doi]
PST - epublish
SO  - Nat Commun. 2017 Sep 8;8(1):495. doi: 10.1038/s41467-017-00594-5.