PMID- 28887539
OWN - NLM
STAT- MEDLINE
DCOM- 20190507
LR  - 20190507
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 7
IP  - 1
DP  - 2017 Sep 8
TI  - Neurogenetic plasticity and sex influence the link between corticolimbic 
      structural connectivity and trait anxiety.
PG  - 10959
LID - 10.1038/s41598-017-11497-2 [doi]
LID - 10959
AB  - Corticolimbic pathways connecting the amygdala and ventral prefrontal cortex 
      (vPFC) are linked with trait anxiety, but it remains unclear what potential 
      genetic moderators contribute to this association. We sought to address this by 
      examining the inter-individual variability in neuroplasticity as modeled by a 
      functional polymorphism (rs6265) in the human gene for brain derived neurotrophic 
      factor (BDNF). Amygdala-vPFC pathway fractional anisotropy (FA) from 669 
      diffusion magnetic resonance images was used to examine associations with trait 
      anxiety as a function of rs6265 genotype. We first replicated the inverse 
      correlation between trait anxiety and amygdala-vPFC pathway FA in women. 
      Furthermore, we found a moderating influence of rs6265 genotype such that the 
      association between trait anxiety and right amygdala-vPFC pathway FA was 
      strongest in women carrying the Met allele, which is linked with decreased 
      activity-dependent neuroplasticity. Results indicate that the microstructural 
      integrity of pathways supporting communication between the amygdala and vPFC help 
      shape the expression of trait anxiety in women, and that this association is 
      further modulated by genetically driven variability in neuroplasticity.
FAU - Kim, M Justin
AU  - Kim MJ
AD  - Laboratory of NeuroGenetics, Department of Psychology and Neuroscience, Duke 
      University, Durham, NC, 27708, USA. justin.kim@duke.edu.
FAU - Avinun, Reut
AU  - Avinun R
AD  - Laboratory of NeuroGenetics, Department of Psychology and Neuroscience, Duke 
      University, Durham, NC, 27708, USA.
FAU - Knodt, Annchen R
AU  - Knodt AR
AD  - Laboratory of NeuroGenetics, Department of Psychology and Neuroscience, Duke 
      University, Durham, NC, 27708, USA.
FAU - Radtke, Spenser R
AU  - Radtke SR
AD  - Laboratory of NeuroGenetics, Department of Psychology and Neuroscience, Duke 
      University, Durham, NC, 27708, USA.
FAU - Hariri, Ahmad R
AU  - Hariri AR
AD  - Laboratory of NeuroGenetics, Department of Psychology and Neuroscience, Duke 
      University, Durham, NC, 27708, USA.
LA  - eng
GR  - R01 AG049789/AG/NIA NIH HHS/United States
GR  - R01 DA031579/DA/NIDA NIH HHS/United States
GR  - R01 DA033369/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20170908
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adolescent
MH  - Amygdala/*diagnostic imaging/physiology
MH  - Anxiety/diagnostic imaging/*genetics
MH  - Brain-Derived Neurotrophic Factor/genetics
MH  - Cerebral Cortex/*diagnostic imaging/physiology
MH  - Connectome
MH  - Female
MH  - Humans
MH  - Male
MH  - *Neuronal Plasticity
MH  - *Polymorphism, Single Nucleotide
MH  - Sex Factors
MH  - Young Adult
PMC - PMC5591318
COIS- The authors declare that they have no competing interests.
EDAT- 2017/09/10 06:00
MHDA- 2019/05/08 06:00
PMCR- 2017/09/08
CRDT- 2017/09/10 06:00
PHST- 2017/05/18 00:00 [received]
PHST- 2017/08/25 00:00 [accepted]
PHST- 2017/09/10 06:00 [entrez]
PHST- 2017/09/10 06:00 [pubmed]
PHST- 2019/05/08 06:00 [medline]
PHST- 2017/09/08 00:00 [pmc-release]
AID - 10.1038/s41598-017-11497-2 [pii]
AID - 11497 [pii]
AID - 10.1038/s41598-017-11497-2 [doi]
PST - epublish
SO  - Sci Rep. 2017 Sep 8;7(1):10959. doi: 10.1038/s41598-017-11497-2.