PMID- 28888148
OWN - NLM
STAT- MEDLINE
DCOM- 20180319
LR  - 20220316
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 133
DP  - 2017 Nov
TI  - Hypoglycemia awareness among insulin-treated patients with diabetes in Malaysia: 
      A cohort subanalysis of the HAT study.
PG  - 40-49
LID - S0168-8227(16)30390-4 [pii]
LID - 10.1016/j.diabres.2017.08.007 [doi]
AB  - AIMS: The present Malaysian cohort analysis determined the prevalence of 
      hypoglycemia among patients with type 1 diabetes mellitus (T1DM) or type 2 
      diabetes mellitus (T2DM) attending primary care- or hospital-based diabetes 
      clinics in Malaysia and their awareness of the symptoms of hypoglycemia. METHODS: 
      The Hypoglycemia Assessment Tool (HAT) study was a non-interventional, 6-month 
      retrospective and 4-week prospective analysis of hypoglycemic events in 24 
      countries, using self-assessment questionnaires and diaries among patients with 
      T1DM/T2DM aged >/=18years, using insulin for >12months. This report focuses on 
      prospective data, as they are less prone to recall bias. RESULTS: There were 1153 
      participants in the Malaysian cohort (114 T1DM; 1039 T2DM). In the prospective 
      period, 50.4% and 33.4% of patients reported >/=1 hypoglycemic events, with 
      estimated rates of 20.3 and 13.1 events per patient-year of exposure in patients 
      with T1DM and T2DM, respectively. 24.8% and 16.1% of patients with T1DM or T2DM, 
      respectively, reported >/=1 nocturnal hypoglycemic event. The majority of patients 
      (96.5%, T1DM; 91.8%, T2DM) knew what hypoglycemia was prior to the study. 
      Impaired awareness was present in 48.0% (T1DM) and 36.9% (T2DM) of patients. In 
      the prospective period, 50% of patients with T1DM or T2DM consulted a doctor or 
      nurse following a hypoglycemia episode. CONCLUSIONS: Half of patients with T1DM 
      and a third of patients with T2DM reported >/=1 hypoglycemic event during the 
      prospective period. Although the majority of patients knew the typical features 
      of hypoglycemia, many reported impaired ability to recognize symptoms in real 
      life. The present findings highlight the importance of patient education and 
      physician awareness in dealing with hypoglycemia, in particular the burden of 
      hypoglycemic unawareness. CLINICAL TRIAL NUMBER: This trial was registered at 
      www.clinicaltrials.gov as NCT01696266 on 26 September 2012.
CI  - Copyright (c) 2017. Published by Elsevier B.V.
FAU - Hussein, Zanariah
AU  - Hussein Z
AD  - Department of Medicine, Hospital Putrajaya, Putrajaya, Malaysia. Electronic 
      address: zanariahh@hotmail.com.
FAU - Kamaruddin, Nor Azmi
AU  - Kamaruddin NA
AD  - Department of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala 
      Lumpur, Malaysia.
FAU - Chan, Siew Pheng
AU  - Chan SP
AD  - Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
FAU - Jain, Anand
AU  - Jain A
AD  - Medical Affairs, Novo Nordisk Region International Operations AG, Zurich, 
      Switzerland.
FAU - Uppal, Shweta
AU  - Uppal S
AD  - Clinical, Medical, Regulatory, and Quality, Novo Nordisk Pharma (Malaysia) Sdn 
      Bhd, Kuala Lumpur, Malaysia.
FAU - Bebakar, Wan Mohamad Wan
AU  - Bebakar WMW
AD  - Department of Medicine, Hospital Universiti Sains Malaysia, Kota Baru, Kelantan, 
      Malaysia.
CN  - HAT study investigators in Malaysia
LA  - eng
SI  - ClinicalTrials.gov/NCT01696266
PT  - Journal Article
PT  - Multicenter Study
DEP - 20170814
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
SB  - IM
MH  - Adult
MH  - Awareness
MH  - Cohort Studies
MH  - Diabetes Complications/*diagnosis
MH  - Diabetes Mellitus, Type 1/*drug therapy
MH  - Female
MH  - Humans
MH  - Hypoglycemia/*chemically induced/diagnosis
MH  - Hypoglycemic Agents/*therapeutic use
MH  - Insulin/*therapeutic use
MH  - Malaysia
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Diabetes
OT  - HAT study
OT  - Hypoglycemia
OT  - Insulin
EDAT- 2017/09/10 06:00
MHDA- 2018/03/20 06:00
CRDT- 2017/09/10 06:00
PHST- 2016/08/19 00:00 [received]
PHST- 2017/04/26 00:00 [revised]
PHST- 2017/08/08 00:00 [accepted]
PHST- 2017/09/10 06:00 [pubmed]
PHST- 2018/03/20 06:00 [medline]
PHST- 2017/09/10 06:00 [entrez]
AID - S0168-8227(16)30390-4 [pii]
AID - 10.1016/j.diabres.2017.08.007 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2017 Nov;133:40-49. doi: 10.1016/j.diabres.2017.08.007. 
      Epub 2017 Aug 14.