PMID- 28889008
OWN - NLM
STAT- MEDLINE
DCOM- 20180611
LR  - 20180611
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 660
DP  - 2017 Nov 1
TI  - The interplay between ventro striatal BDNF levels and the effects of valproic 
      acid on the acquisition of ethanol-induced conditioned place preference in mice.
PG  - 86-89
LID - S0304-3940(17)30743-7 [pii]
LID - 10.1016/j.neulet.2017.09.009 [doi]
AB  - Alcohol addiction is a chronic, relapsing and progressive brain disease with 
      serious consequences for health. Compulsive use of alcohol is associated with the 
      capacity to change brain structures involved with the reward pathway, such as 
      ventral striatum. Recent evidence suggests a role of chromatin remodeling in the 
      pathophysiology of alcohol dependence and addictive-like behaviors. In addition, 
      neuroadaptive changes mediated by the brain-derived neurotrophic factor (BDNF) 
      seems to be an interesting pharmacological target for alcoholism treatment. In 
      the present study, we evaluated the effects of the deacetylase inhibitor valproic 
      acid (VPA) (300mg/kg) on the conditioned rewarding effects of ethanol using 
      conditioned place preference (CPP) (15% v/v; 2g/kg). Ethanol rewarding effect was 
      investigated using a biased protocol of CPP. BDNF levels were measured in the 
      ventral striatum. Ethanol administration induced CPP. VPA pretreatment did not 
      reduce ethanol-CPP acquisition. VPA pretreatment increased BDNF levels when 
      compared to ethanol induced-CPP. VPA pretreatment increased BDNF levels even in 
      saline conditioned mice. Taken together, our results indicate a modulatory effect 
      of VPA on the BDNF levels in the ventral striatum. Overall, this study brings 
      initial insights into the involvement of neurotrophic mechanisms in the ventral 
      striatum in ethanol-induced addictive-like behavior.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Dos Santos, Manuel Alves Junior
AU  - Dos Santos MA Junior
AD  - Neuropsychopharmacology Laboratory, Drug Research and Development Center, Faculty 
      of Medicine, Universidade Federal do Ceara/UFC, Brazil.
FAU - Escudeiro, Sarah Sousa
AU  - Escudeiro SS
AD  - Neuropsychopharmacology Laboratory, Drug Research and Development Center, Faculty 
      of Medicine, Universidade Federal do Ceara/UFC, Brazil.
FAU - Vasconcelos, Germana Silva
AU  - Vasconcelos GS
AD  - Neuropsychopharmacology Laboratory, Drug Research and Development Center, Faculty 
      of Medicine, Universidade Federal do Ceara/UFC, Brazil.
FAU - Matos, Natalia Castelo Branco
AU  - Matos NCB
AD  - Neuropsychopharmacology Laboratory, Drug Research and Development Center, Faculty 
      of Medicine, Universidade Federal do Ceara/UFC, Brazil.
FAU - de Souza, Marcos Romario Matos
AU  - de Souza MRM
AD  - Neuropsychopharmacology Laboratory, Drug Research and Development Center, Faculty 
      of Medicine, Universidade Federal do Ceara/UFC, Brazil.
FAU - Patrocinio, Manoel Claudio Azevedo
AU  - Patrocinio MCA
AD  - Pharmacology Laboratory, Medicine School, Unichristus University 
      Center/Unichristus, Fortaleza, Brazil; Department of Anesthesiology, Dr. Jose 
      Frota Institute Hospital/IJF, Fortaleza, Brazil.
FAU - Dantas, Leonardo Pimentel
AU  - Dantas LP
AD  - General Hospital of Fortaleza, Fortaleza, Ceara, Brazil.
FAU - Macedo, Danielle
AU  - Macedo D
AD  - Neuropsychopharmacology Laboratory, Drug Research and Development Center, Faculty 
      of Medicine, Universidade Federal do Ceara/UFC, Brazil.
FAU - Vasconcelos, Silvania Maria Mendes
AU  - Vasconcelos SMM
AD  - Neuropsychopharmacology Laboratory, Drug Research and Development Center, Faculty 
      of Medicine, Universidade Federal do Ceara/UFC, Brazil. Electronic address: 
      silvania_vasconcelos@yahoo.com.br.
LA  - eng
PT  - Journal Article
DEP - 20170906
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 3K9958V90M (Ethanol)
RN  - 614OI1Z5WI (Valproic Acid)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Conditioning, Classical/drug effects
MH  - *Drug-Seeking Behavior
MH  - Ethanol/*administration & dosage
MH  - Male
MH  - Mice
MH  - Reward
MH  - Valproic Acid/*administration & dosage
MH  - Ventral Striatum/*drug effects/*metabolism
OTO - NOTNLM
OT  - BDNF
OT  - Conditioned place preference
OT  - Ethanol
OT  - Valproic acid
OT  - Ventral striatum
EDAT- 2017/09/11 06:00
MHDA- 2018/06/12 06:00
CRDT- 2017/09/11 06:00
PHST- 2017/05/30 00:00 [received]
PHST- 2017/08/25 00:00 [revised]
PHST- 2017/09/05 00:00 [accepted]
PHST- 2017/09/11 06:00 [pubmed]
PHST- 2018/06/12 06:00 [medline]
PHST- 2017/09/11 06:00 [entrez]
AID - S0304-3940(17)30743-7 [pii]
AID - 10.1016/j.neulet.2017.09.009 [doi]
PST - ppublish
SO  - Neurosci Lett. 2017 Nov 1;660:86-89. doi: 10.1016/j.neulet.2017.09.009. Epub 2017 
      Sep 6.