PMID- 28889180
OWN - NLM
STAT- MEDLINE
DCOM- 20180612
LR  - 20191210
IS  - 1432-5195 (Electronic)
IS  - 0341-2695 (Linking)
VI  - 41
IP  - 11
DP  - 2017 Nov
TI  - The degree of cartilage degradation assessed by serum biomarker levels changes 
      after arthroscopic knee synovectomy in rheumatoid arthritis patients.
PG  - 2259-2264
LID - 10.1007/s00264-017-3634-8 [doi]
AB  - PURPOSE: In order to test the validity of the selected surgical technique as a 
      way to manage persistent synovitis of the knee joint, as well as to slow down the 
      cartilage and bone destruction, we studied the dynamics of biomarkers of 
      inflammatory conditions, and bone and cartilage destruction after total 
      arthroscopic synovectomy (TAS) of the knee joint. METHODS: The sampling comprised 
      124 RA patients (158 knees) who had undergone the TAS procedure between 2003 and 
      2015. Before surgery the rheumatoid factor (IgM), C-reactive protein (CRP), 
      erythrocyte sedimentation rate test was completed for all patients. Blood serum 
      samples were collected (prior to surgery, and three, six and 12 months after 
      surgery) and frozen at -70 degrees capital ES, Cyrillic. The content of CRP, Matrix metalloproteinase-3 
      (MMP-3), Cartilage Oligomeric Matrix Protein, as well as cross-linked 
      Ctelopeptides of types I and II were measured in blood serum by means of 
      polarization fluoroimmunoassay with the use of a standard set of reagents. 
      RESULTS: The average duration of the disease in the studied group was 
      8.7 +/- 6.6 years. Concentration of the inflammation markers showed that only MMP-3 
      displayed statistical significance. CONCLUSIONS: The obtained results can be used 
      as basis in assessing the efficiency and effectiveness of this method of 
      treatment of persistent knee joint synovitis associated with the RA.
FAU - Lipina, Marina
AU  - Lipina M
AUID- ORCID: 0000-0003-1240-4064
AD  - V.A. Nasonova Research Institute of Rheumatology, Moscow, Russian Federation. 
      marina.lipina@icloud.com.
FAU - Makarov, Maxim
AU  - Makarov M
AD  - V.A. Nasonova Research Institute of Rheumatology, Moscow, Russian Federation.
FAU - Makarov, Sergey
AU  - Makarov S
AD  - V.A. Nasonova Research Institute of Rheumatology, Moscow, Russian Federation.
FAU - Novikov, Alexander
AU  - Novikov A
AD  - V.A. Nasonova Research Institute of Rheumatology, Moscow, Russian Federation.
LA  - eng
PT  - Journal Article
PT  - Validation Study
DEP - 20170909
PL  - Germany
TA  - Int Orthop
JT  - International orthopaedics
JID - 7705431
RN  - 0 (Biomarkers)
RN  - 0 (COMP protein, human)
RN  - 0 (Cartilage Oligomeric Matrix Protein)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Arthritis, Rheumatoid/complications/*surgery
MH  - Arthroscopy/*adverse effects/methods
MH  - Biomarkers/*blood
MH  - Bone and Bones/pathology
MH  - C-Reactive Protein/analysis
MH  - Cartilage/pathology
MH  - Cartilage Diseases/*etiology/surgery
MH  - Cartilage Oligomeric Matrix Protein/blood
MH  - Female
MH  - Fluorescence Polarization Immunoassay
MH  - Humans
MH  - Knee Joint/pathology/surgery
MH  - Male
MH  - Matrix Metalloproteinase 3/blood
MH  - Middle Aged
MH  - ROC Curve
MH  - Synovectomy/*adverse effects/methods
MH  - Synovial Membrane
MH  - Synovitis/etiology/*surgery
OTO - NOTNLM
OT  - Biomarkers of bone and cartilage destruction
OT  - Rheumatoid arthritis
OT  - Total knee synovectomy
EDAT- 2017/09/11 06:00
MHDA- 2018/06/13 06:00
CRDT- 2017/09/11 06:00
PHST- 2017/04/22 00:00 [received]
PHST- 2017/08/28 00:00 [accepted]
PHST- 2017/09/11 06:00 [pubmed]
PHST- 2018/06/13 06:00 [medline]
PHST- 2017/09/11 06:00 [entrez]
AID - 10.1007/s00264-017-3634-8 [pii]
AID - 10.1007/s00264-017-3634-8 [doi]
PST - ppublish
SO  - Int Orthop. 2017 Nov;41(11):2259-2264. doi: 10.1007/s00264-017-3634-8. Epub 2017 
      Sep 9.