PMID- 28889782
OWN - NLM
STAT- MEDLINE
DCOM- 20180806
LR  - 20220409
IS  - 1651-2251 (Electronic)
IS  - 0001-6489 (Linking)
VI  - 138
IP  - 1
DP  - 2018 Jan
TI  - Sex-related hormone receptor in laryngeal squamous cell carcinoma: correlation 
      with androgen estrogen-a and prolactin receptor expression and influence of 
      prognosis.
PG  - 66-72
LID - 10.1080/00016489.2017.1373851 [doi]
AB  - BACKGROUND: The expression and function of androgen receptors (AR) and estrogen 
      receptor alpha (ER-a) in laryngeal squamous cell carcinoma (LSCC) have remained 
      controversial for decades. Prolactin receptor (PRLR) is a sex-related hormone, 
      that has been rarely documented in terms of expression or function compared with 
      data on other hormone receptors in laryngeal carcinoma. METHODS: This study 
      reports on immunohistochemical and reverse transcription-polymerase chain 
      reaction (RT-PCR) analysis of tumour tissue and adjacent normal tissue in 96 
      patients with LSCC (82 males and 14 females). The expression levels of the 
      receptors were related to clinicopathologic parameters and survival data. 
      RESULTS: At both protein and mRNA levels, the expression level of AR, ER-a, and 
      PRLR was much higher in LSCC than in adjacent normal tissues (p < .05). Among 
      them, higher PRLR expression in tumour tissues tended to have a significantly 
      poorer survival rate (p = .03) for patients with LSCC. Furthermore, higher 
      expression of ER-a in tumours was correlated with higher expression level of PRLR 
      (r = .823, p = .03). CONCLUSION: The findings of this study indicate that the 
      sex-related hormone receptors play an important role in the development of LSCC. 
      The PRLR represents a novel prognosticator, because of its negative effect on 
      survival and its interaction with ER-a.
FAU - Fei, Mengjia
AU  - Fei M
AD  - a Department of Head and Neck Surgery , Renji Hospital, School of Medicine, 
      Shanghai Jiao Tong University , Shanghai , China.
FAU - Zhang, Jingwen
AU  - Zhang J
AD  - b Department of Ultrasound , Ruijin Hospital, Shanghai Jiao Tong University 
      School of Medicine , Shanghai , China.
FAU - Zhou, Jiaqing
AU  - Zhou J
AD  - a Department of Head and Neck Surgery , Renji Hospital, School of Medicine, 
      Shanghai Jiao Tong University , Shanghai , China.
FAU - Xu, Yanan
AU  - Xu Y
AD  - a Department of Head and Neck Surgery , Renji Hospital, School of Medicine, 
      Shanghai Jiao Tong University , Shanghai , China.
FAU - Wang, Jiadong
AU  - Wang J
AD  - a Department of Head and Neck Surgery , Renji Hospital, School of Medicine, 
      Shanghai Jiao Tong University , Shanghai , China.
LA  - eng
PT  - Journal Article
DEP - 20170911
PL  - England
TA  - Acta Otolaryngol
JT  - Acta oto-laryngologica
JID - 0370354
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Androgen)
RN  - 0 (Receptors, Prolactin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/genetics/metabolism
MH  - Carcinoma, Squamous Cell/*metabolism/mortality
MH  - Estrogen Receptor alpha/genetics/*metabolism
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Kaplan-Meier Estimate
MH  - Laryngeal Neoplasms/*metabolism/mortality
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - RNA, Messenger/metabolism
MH  - Receptors, Androgen/genetics/*metabolism
MH  - Receptors, Prolactin/genetics/*metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Survival Rate
OTO - NOTNLM
OT  - Laryngeal carcinoma
OT  - androgen receptor
OT  - estrogen receptor alpha
OT  - overall survival
OT  - prolactin receptor
EDAT- 2017/09/12 06:00
MHDA- 2018/08/07 06:00
CRDT- 2017/09/12 06:00
PHST- 2017/09/12 06:00 [pubmed]
PHST- 2018/08/07 06:00 [medline]
PHST- 2017/09/12 06:00 [entrez]
AID - 10.1080/00016489.2017.1373851 [doi]
PST - ppublish
SO  - Acta Otolaryngol. 2018 Jan;138(1):66-72. doi: 10.1080/00016489.2017.1373851. Epub 
      2017 Sep 11.