PMID- 28890029
OWN - NLM
STAT- MEDLINE
DCOM- 20180507
LR  - 20220331
IS  - 1532-2653 (Electronic)
IS  - 0967-5868 (Linking)
VI  - 46
DP  - 2017 Dec
TI  - Natural course and predictors of severe disability and death in Thai patients 
      with dementia.
PG  - 37-40
LID - S0967-5868(17)30998-0 [pii]
LID - 10.1016/j.jocn.2017.08.040 [doi]
AB  - More than half of patients with dementia lived in countries with low and middle 
      incomes. However, there have been few studies on the natural course of disease in 
      these countries. The purpose of this study was to study the natural course and 
      the predictive factors of advanced stage and death in Thai patients with 
      dementia. Patients with dementia who were treated in neurologic and psychiatric 
      clinic from September 2004 to February 2016, were included. Data about natural 
      course of diseases, behavioral and psychological symptoms in dementia (BPSD) and 
      complications were studied. 207 patients were included. Mean age was 77years old. 
      Mean Thai Mental State Examination (TMSE) was 17.5. Alzheimer's disease was the 
      most common cause of dementia (55%). With the mean follow-up of 39months (range 
      from 2 to 126months), 64% of the patients had BPSD. Sixty-two patients (30%) had 
      complications required admission. Seven patients died. Fifty-four patients (29%) 
      ended in the advanced stage of dementia. Mean duration from diagnosis to the 
      advanced stage was 49months. Complications that required admission usually 
      occurred in moderate to severe dementia and were strongly associated with the 
      advanced stage or death (OR 6.1, 95%CI 2.57-14.49, p-value<0.0001). Alzheimer's 
      disease was the most common cause of dementia in the study. Most demented 
      patients presented in moderate severity of dementia. Mean duration from diagnosis 
      to the advanced stage of dementia was approximate 4-5years. Complications 
      required admissions related to the progression to advanced stage or death.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Dharmasaroja, Pornpatr A
AU  - Dharmasaroja PA
AD  - Stroke and Neurodegenerative Diseases Research Unit, Faculty of Medicine, 
      Thammasat University, Klong 1, Klong Luang, Pathumthani 12120, Thailand. 
      Electronic address: pornpatr1@hotmail.com.
FAU - Lolekha, Praween
AU  - Lolekha P
AD  - Stroke and Neurodegenerative Diseases Research Unit, Faculty of Medicine, 
      Thammasat University, Klong 1, Klong Luang, Pathumthani 12120, Thailand.
FAU - Kulkantrakorn, Kongkiat
AU  - Kulkantrakorn K
AD  - Department of Internal Medicine, Faculty of Medicine, Thammasat University, Klong 
      1, Klong Luang, Pathumthani 12120, Thailand.
FAU - Charernboon, Thammanard
AU  - Charernboon T
AD  - Stroke and Neurodegenerative Diseases Research Unit, Faculty of Medicine, 
      Thammasat University, Klong 1, Klong Luang, Pathumthani 12120, Thailand.
FAU - Watcharakorn, Arvemas
AU  - Watcharakorn A
AD  - Stroke and Neurodegenerative Diseases Research Unit, Faculty of Medicine, 
      Thammasat University, Klong 1, Klong Luang, Pathumthani 12120, Thailand.
FAU - Piyabhan, Pritsana
AU  - Piyabhan P
AD  - Stroke and Neurodegenerative Diseases Research Unit, Faculty of Medicine, 
      Thammasat University, Klong 1, Klong Luang, Pathumthani 12120, Thailand.
LA  - eng
PT  - Journal Article
DEP - 20170908
PL  - Scotland
TA  - J Clin Neurosci
JT  - Journal of clinical neuroscience : official journal of the Neurosurgical Society 
      of Australasia
JID - 9433352
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Dementia/complications/mortality
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Thailand
OTO - NOTNLM
OT  - Advanced dementia
OT  - Alzheimer's disease
OT  - Asian
OT  - Dementia
OT  - Thai
EDAT- 2017/09/12 06:00
MHDA- 2018/05/08 06:00
CRDT- 2017/09/12 06:00
PHST- 2017/05/25 00:00 [received]
PHST- 2017/08/15 00:00 [accepted]
PHST- 2017/09/12 06:00 [pubmed]
PHST- 2018/05/08 06:00 [medline]
PHST- 2017/09/12 06:00 [entrez]
AID - S0967-5868(17)30998-0 [pii]
AID - 10.1016/j.jocn.2017.08.040 [doi]
PST - ppublish
SO  - J Clin Neurosci. 2017 Dec;46:37-40. doi: 10.1016/j.jocn.2017.08.040. Epub 2017 
      Sep 8.