PMID- 28890466
OWN - NLM
STAT- MEDLINE
DCOM- 20171212
LR  - 20220409
IS  - 2186-1005 (Electronic)
IS  - 1341-1098 (Print)
IS  - 1341-1098 (Linking)
VI  - 23
IP  - 5
DP  - 2017 Oct 20
TI  - Changes in Aortic Pulse Wave Velocity and the Predictors of Improvement in 
      Arterial Stiffness Following Aortic Valve Replacement.
PG  - 248-255
LID - 10.5761/atcs.oa.17-00062 [doi]
AB  - BACKGROUND: The interaction between valvular aortic stenosis (AS) and arterial 
      stiffness, as well as the impact of aortic valve replacement (AVR) on arterial 
      stiffness, remains unclear. In this study, we aimed to evaluate the degree of AS 
      severity on non-invasive pulse wave velocity (PWV) measurements. We also searched 
      whether the AVR procedure favorably affects PWV. METHODS: In all, 38 patients 
      undergoing AVR for chronic AS were included. The degree of aortic stiffness was 
      measured with PWV at both baseline and 6 months after AVR. Improvement in aortic 
      stiffness was defined as the absolute decrease in PWV at 6 months compared to the 
      baseline value. RESULTS: The study population had a mean age of 59 +/- 16 years, 
      mean aortic gradient of 47.1 +/- 6.4 mmHg, and mean aortic valve area (AVA) index 
      of 0.45 +/- 0.11 cm(2) /m(2) . Baseline PWV values correlated positively with the mean 
      aortic gradient (r = 0.350, p = 0.031) and negatively with the AVA index (r = 
      -0.512, p = 0.001). The mean PWV improved in 20 patients (53%) and worsened in 18 
      patients (47%). The baseline New York Heart Association (NYHA) class (odds ratio 
      [OR] = 1.023, 95% confidence interval [CI] = 1.005-1.041, p = 0.041) and AVA 
      index (OR = 1.040, 96% CI = 1.023-1.057, p = 0.028) emerged as the independent 
      predictors of improvement in PWV following AVR. CONCLUSION: The severity of AS 
      was significantly associated with baseline PWV. In general, the mean PWV did not 
      change with AVR. Baseline NYHA class and the AVA index independently predicted 
      PWV improvement following AVR. Since the change in PWV after AVR was polarized 
      based on the patients' characteristics, such as preoperative NYHA functional 
      class or AVA index, further studies are needed to confirm clinical significance 
      of PWV change following AVR in severe AS patients.
FAU - Canturk, Emir
AU  - Canturk E
AD  - Department of Cardiovascular Surgery, Dragos Hospital, Bezm-i Alem University, 
      Istanbul, Turkey.
FAU - Cakal, Beytullah
AU  - Cakal B
AD  - Department of Cardiology, Istanbul Medipol University, Istanbul, Turkey.
FAU - Karaca, Oguz
AU  - Karaca O
AD  - Department of Cardiology, Istanbul Medipol University, Istanbul, Turkey.
FAU - Omaygenc, Onur
AU  - Omaygenc O
AD  - Department of Cardiology, Istanbul Medipol University, Istanbul, Turkey.
FAU - Salihi, Salih
AU  - Salihi S
AD  - Department of Cardiovascular Surgery, Okan University, Istanbul, Turkey.
FAU - Ozyuksel, Arda
AU  - Ozyuksel A
AD  - Department of Cardiovascular Surgery, Istanbul Medipol University, Istanbul, 
      Turkey.
FAU - Akcevin, Atif
AU  - Akcevin A
AD  - Department of Cardiovascular Surgery, Istanbul Medipol University, Istanbul, 
      Turkey.
LA  - eng
PT  - Journal Article
DEP - 20170908
PL  - Japan
TA  - Ann Thorac Cardiovasc Surg
JT  - Annals of thoracic and cardiovascular surgery : official journal of the 
      Association of Thoracic and Cardiovascular Surgeons of Asia
JID - 9703158
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aortic Valve/diagnostic imaging/physiopathology/*surgery
MH  - Aortic Valve Stenosis/diagnosis/physiopathology/*surgery
MH  - Chi-Square Distribution
MH  - Disease Progression
MH  - Female
MH  - *Heart Valve Prosthesis Implantation/adverse effects
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Odds Ratio
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - *Pulse Wave Analysis
MH  - Recovery of Function
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Time Factors
MH  - Treatment Outcome
MH  - *Vascular Stiffness
PMC - PMC5655337
OTO - NOTNLM
OT  - aortic stenosis
OT  - aortic stiffness
OT  - pulse wave velocity
EDAT- 2017/09/12 06:00
MHDA- 2017/12/13 06:00
PMCR- 2017/01/01
CRDT- 2017/09/12 06:00
PHST- 2017/09/12 06:00 [pubmed]
PHST- 2017/12/13 06:00 [medline]
PHST- 2017/09/12 06:00 [entrez]
PHST- 2017/01/01 00:00 [pmc-release]
AID - atcs.oa.17-00062 [pii]
AID - 10.5761/atcs.oa.17-00062 [doi]
PST - ppublish
SO  - Ann Thorac Cardiovasc Surg. 2017 Oct 20;23(5):248-255. doi: 
      10.5761/atcs.oa.17-00062. Epub 2017 Sep 8.