PMID- 28891092
OWN - NLM
STAT- MEDLINE
DCOM- 20171003
LR  - 20180424
IS  - 1749-6632 (Electronic)
IS  - 0077-8923 (Linking)
VI  - 1401
IP  - 1
DP  - 2017 Aug
TI  - Plant non-starch polysaccharides that inhibit key enzymes linked to type 2 
      diabetes mellitus.
PG  - 28-36
LID - 10.1111/nyas.13430 [doi]
AB  - Type 2 diabetes mellitus (T2DM), a metabolic disease becoming ever more common, 
      is the result of disturbed glyco- and lipid metabolism. On the basis of their 
      inhibitory effects against several key enzymes linked to T2DM, synthetic 
      antidiabetic agents have been developed and used for diabetic therapy, some with 
      adverse side effects. Fortunately, many plant non-starch polysaccharides (NSPs) 
      have been shown to possess inhibitory effects on the same T2DM-related enzymes. 
      Through a simple literature search we found that alpha-amylase, alpha-glucosidase, 
      lipase, and dipeptidyl-peptidase IV are the enzymes most often reported in the 
      context of T2DM. In this short review we discuss published evidence for 
      inhibition of these enzymes and the implications for treating T2DM.
CI  - (c) 2017 New York Academy of Sciences.
FAU - Liu, Dan
AU  - Liu D
AD  - State Key Laboratory of Food Science and Technology, Nanchang University, 
      Nanchang, Jiangxi, China.
FAU - Gao, He
AU  - Gao H
AD  - State Key Laboratory of Food Science and Technology, Nanchang University, 
      Nanchang, Jiangxi, China.
FAU - Tang, Wei
AU  - Tang W
AD  - State Key Laboratory of Food Science and Technology, Nanchang University, 
      Nanchang, Jiangxi, China.
FAU - Nie, Shaoping
AU  - Nie S
AD  - State Key Laboratory of Food Science and Technology, Nanchang University, 
      Nanchang, Jiangxi, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Plant Extracts)
RN  - 0 (Polysaccharides)
RN  - EC 3.1.1.3 (Lipase)
RN  - EC 3.2.1.1 (alpha-Amylases)
RN  - EC 3.4.14.5 (Dipeptidyl Peptidase 4)
SB  - IM
MH  - Diabetes Mellitus, Type 2/drug therapy/*enzymology
MH  - Dipeptidyl Peptidase 4/metabolism
MH  - Enzyme Inhibitors/chemistry/*pharmacology/therapeutic use
MH  - Humans
MH  - Lipase/antagonists & inhibitors/metabolism
MH  - Plant Extracts/chemistry/*pharmacology/therapeutic use
MH  - Polysaccharides/chemistry/*pharmacology/therapeutic use
MH  - alpha-Amylases/antagonists & inhibitors/metabolism
OTO - NOTNLM
OT  - inhibition activity
OT  - key enzymes
OT  - plant non-starch polysaccharides
OT  - type 2 diabetes mellitus
EDAT- 2017/09/12 06:00
MHDA- 2017/10/04 06:00
CRDT- 2017/09/12 06:00
PHST- 2017/04/04 00:00 [received]
PHST- 2017/06/12 00:00 [revised]
PHST- 2017/06/12 00:00 [accepted]
PHST- 2017/09/12 06:00 [entrez]
PHST- 2017/09/12 06:00 [pubmed]
PHST- 2017/10/04 06:00 [medline]
AID - 10.1111/nyas.13430 [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2017 Aug;1401(1):28-36. doi: 10.1111/nyas.13430.