PMID- 28891383
OWN - NLM
STAT- MEDLINE
DCOM- 20181127
LR  - 20181127
IS  - 1557-8577 (Electronic)
IS  - 1549-1684 (Linking)
VI  - 21
IP  - 5
DP  - 2018 Oct
TI  - A Hypothesis: Moderate Consumption of Alcohol Contributes to Lower Prevalence of 
      Type 2 Diabetes Due to the Scavenging of Alpha-Dicarbonyls by Dietary 
      Polyphenols.
PG  - 389-404
LID - 10.1089/rej.2017.1974 [doi]
AB  - The world is experiencing an epidemic of type-2-diabetes mellitus (T2DM). This 
      has led to increased morbidity and mortality, explosive growth in health care 
      budgets, and an even greater adverse, if indirect, impact on societies and 
      economies of affected countries. While genetic susceptibility to T2DM is a major 
      determinant of its prevalence, changes in lifestyles also play a role. One such 
      change has been a transition from traditional diets characterized by low caloric 
      and high nutrient density to calorie-rich but nutrient-poor Western diets. Given 
      this, one solution to the epidemic of T2DM would be to abandon Western diets and 
      revert to traditional eating patterns. However, traditional diets cannot provide 
      enough calories for the increasing global population, so transition from 
      traditional to Western foodstuffs appears to be irreversible. Consequently, the 
      only practical solution to problems caused by these changes is to modify Western 
      diets, possibly by supplementing them with functional foods containing nutrients 
      that would compensate for these dietary deficits. I present in this study a 
      hypothesis to explain why shifts from traditional to Western diets have been so 
      problematic and to suggest nutrients that may counteract these adverse effects. I 
      postulate that the components of traditional diets that may compensate for 
      deficiencies of Westerns diets are scavengers of reactive alpha-dicarbonyls produced 
      as unavoidable by-products of glucose and lipid metabolism. Most important among 
      these scavengers are some plant secondary metabolites: polyphenols, 
      phlorotannins, and carotenoids. They are found in alcoholic beverages and are 
      abundant in seasonings, cocoa, coffee, tea, whole grains, pigmented vegetables, 
      fruits, and berries.
FAU - Szwergold, Benjamin
AU  - Szwergold B
AD  - SeroClear, Inc. , Newark, New Jersey.
LA  - eng
PT  - Journal Article
DEP - 20171101
PL  - United States
TA  - Rejuvenation Res
JT  - Rejuvenation research
JID - 101213381
RN  - 0 (Free Radical Scavengers)
RN  - 0 (Polyphenols)
RN  - 3352-57-6 (Hydroxyl Radical)
RN  - 9G2MP84A8W (Deoxyglucose)
SB  - IM
MH  - *Alcohol Drinking
MH  - Deoxyglucose/*analogs & derivatives/chemistry
MH  - Diabetes Mellitus, Type 2/epidemiology/*prevention & control
MH  - *Diet
MH  - Free Radical Scavengers/*therapeutic use
MH  - Humans
MH  - Hydroxyl Radical/*chemistry
MH  - Life Style
MH  - Polyphenols/*therapeutic use
OTO - NOTNLM
OT  - alcohol
OT  - diabetes
OT  - dicarbonyl
OT  - diet
OT  - phytochemical
EDAT- 2017/09/12 06:00
MHDA- 2018/11/28 06:00
CRDT- 2017/09/12 06:00
PHST- 2017/09/12 06:00 [pubmed]
PHST- 2018/11/28 06:00 [medline]
PHST- 2017/09/12 06:00 [entrez]
AID - 10.1089/rej.2017.1974 [doi]
PST - ppublish
SO  - Rejuvenation Res. 2018 Oct;21(5):389-404. doi: 10.1089/rej.2017.1974. Epub 2017 
      Nov 1.