PMID- 28893360
OWN - NLM
STAT- MEDLINE
DCOM- 20171018
LR  - 20171018
IS  - 1473-5644 (Electronic)
IS  - 0022-2615 (Linking)
VI  - 66
IP  - 10
DP  - 2017 Oct
TI  - Borderline oxacillin-resistant Staphylococcus aureus (BORSA) - a more common 
      problem than expected?
PG  - 1367-1373
LID - 10.1099/jmm.0.000585 [doi]
AB  - Borderline oxacillin-resistant Staphylococcus aureus (BORSA) represents a quite 
      poorly understood and inadequately defined phenotype of methicillin resistance. 
      BORSA strains show low, borderline resistance to penicillinase-resistant 
      penicillins (PRPs), with oxacillin MICs typically equal to 1-8 microg ml(-1), and in 
      contrast to methicillin-resistant S. aureus (MRSA), do not have an altered 
      penicillin-binding protein, PBP2a, encoded by the mecA or mecC gene. Their 
      resistance is typically associated with hyperproduction of beta-lactamases or, in 
      some cases, point mutations in PBP genes. BORSA cannot be classified as either 
      truly methicillin-resistant or truly methicillin-susceptible strains. However, 
      they are frequently misidentified, which poses an obvious epidemiological and 
      therapeutic threat. BORSA strains are commonly isolated from humans and animals, 
      and are found both in hospitals and in a community setting. The epidemiology and 
      clinical presentation of BORSA infections seem to be similar to those for MRSA; 
      these infections are usually more severe than those caused by 
      methicillin-sensitive S. aureus (MSSA). Treatment of severe infections caused by 
      BORSA may be ineffective, even with larger doses of oxacillin. The available 
      evidence suggests that BORSA represent a frequently neglected problem, and their 
      emergence in new environments implies that they need to be monitored and 
      accurately distinguished from MSSA and MRSA.
FAU - Hryniewicz, Maria M
AU  - Hryniewicz MM
AD  - Department of Oral Microbiology, Medical University of Gdansk, Debowa 25, 80-204 
      Gdansk, Poland.
FAU - Garbacz, Katarzyna
AU  - Garbacz K
AD  - Department of Oral Microbiology, Medical University of Gdansk, Debowa 25, 80-204 
      Gdansk, Poland.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170912
PL  - England
TA  - J Med Microbiol
JT  - Journal of medical microbiology
JID - 0224131
RN  - 0 (Anti-Bacterial Agents)
RN  - UH95VD7V76 (Oxacillin)
SB  - IM
MH  - Anti-Bacterial Agents/*pharmacology
MH  - *Drug Resistance, Bacterial
MH  - Humans
MH  - Microbial Sensitivity Tests
MH  - Oxacillin/*pharmacology
MH  - Staphylococcal Infections/*drug therapy/*microbiology
MH  - Staphylococcus aureus/*drug effects
OTO - NOTNLM
OT  - Antibiotic resistance
OT  - BORSA
OT  - MRSA
EDAT- 2017/09/13 06:00
MHDA- 2017/10/19 06:00
CRDT- 2017/09/13 06:00
PHST- 2017/09/13 06:00 [pubmed]
PHST- 2017/10/19 06:00 [medline]
PHST- 2017/09/13 06:00 [entrez]
AID - 10.1099/jmm.0.000585 [doi]
PST - ppublish
SO  - J Med Microbiol. 2017 Oct;66(10):1367-1373. doi: 10.1099/jmm.0.000585. Epub 2017 
      Sep 12.