PMID- 28895099
OWN - NLM
STAT- MEDLINE
DCOM- 20180720
LR  - 20201209
IS  - 1538-2443 (Electronic)
IS  - 1355-0284 (Linking)
VI  - 23
IP  - 6
DP  - 2017 Dec
TI  - Neurological and multiple organ involvement due to Paracoccidioides brasiliensis 
      and HIV co-infection diagnosed at autopsy.
PG  - 913-918
LID - 10.1007/s13365-017-0577-1 [doi]
AB  - Paracoccidioidomycosis (PCM), caused by Paracoccidioides brasiliensis, is the 
      most prevalent systemic mycosis among immunocompetent patients in Latin America; 
      it is rare in immunocompromised patients. The estimated frequency of central 
      nervous system (CNS) involvement in the HIV/PCM population was 2.5%. We report a 
      case of HIV/P. brasiliensis co-infection, with neurological (NPCM) and multiple 
      organ involvement, indicating a diagnosis of AIDS. PCM diagnosis was established 
      during the autopsy. This is the first described case of HIV/P. brasiliensis 
      co-infection with CNS involvement diagnosed at autopsy. In conclusion, the 
      diagnosis of NPCM is challenging, and it must be considered in the differential 
      diagnosis in HIV-positive patients who reside in or have visited areas in which 
      the condition is endemic and who present with neurological symptoms.
FAU - de Almeida, Sergio Monteiro
AU  - de Almeida SM
AD  - Medical Pathology Department, Medicine School, Universidade Federal do Parana, 
      Curitiba, Parana, Brazil. sergio.ma@ufpr.br.
AD  - Virology Laboratory, Hospital de Clinicas, Universidade Federal do Parana, 
      Curitiba, Parana, Brazil. sergio.ma@ufpr.br.
AD  - Faculdades Pequeno Principe, Curitiba, Parana, Brazil. sergio.ma@ufpr.br.
AD  - Instituto de Pesquisa Pele Pequeno Principe, Curitiba, Parana, Brazil. 
      sergio.ma@ufpr.br.
AD  - Hospital de Clinicas-UFPR, Secao de Virologia, Setor Analises Clinicas, Rua Padre 
      Camargo, 280, Curitiba, PR, Brazil. sergio.ma@ufpr.br.
FAU - Roza, Thiago H
AU  - Roza TH
AD  - Medical Pathology Department, Medicine School, Universidade Federal do Parana, 
      Curitiba, Parana, Brazil.
FAU - Salvador, Gabriel L O
AU  - Salvador GLO
AD  - Medical Pathology Department, Medicine School, Universidade Federal do Parana, 
      Curitiba, Parana, Brazil.
FAU - Franca, Joao C B
AU  - Franca JCB
AD  - Infectious Diseases Unit, Hospital de Clinicas, Universidade Federal do Parana, 
      Curitiba, Parana, Brazil.
FAU - Vidal, Luine Rosele Renaud
AU  - Vidal LRR
AD  - Virology Laboratory, Hospital de Clinicas, Universidade Federal do Parana, 
      Curitiba, Parana, Brazil.
FAU - Nogueira, Meri Bordignon
AU  - Nogueira MB
AD  - Virology Laboratory, Hospital de Clinicas, Universidade Federal do Parana, 
      Curitiba, Parana, Brazil.
FAU - Oliva, Lubomira Veronica
AU  - Oliva LV
AD  - Medical Pathology Department, Medicine School, Universidade Federal do Parana, 
      Curitiba, Parana, Brazil.
FAU - Torres, Luis Fernando Bleggi
AU  - Torres LFB
AD  - Medical Pathology Department, Medicine School, Universidade Federal do Parana, 
      Curitiba, Parana, Brazil.
FAU - de Noronha, Lucia Helena
AU  - de Noronha LH
AD  - Medical Pathology Department, Medicine School, Universidade Federal do Parana, 
      Curitiba, Parana, Brazil.
AD  - Laboratorio de Patologia Experimental, Escola de Medicina- Pontificia 
      Universidade Catolica do Parana, Curitiba, Parana, Brazil.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20170911
PL  - United States
TA  - J Neurovirol
JT  - Journal of neurovirology
JID - 9508123
SB  - IM
MH  - Acute Kidney Injury/*diagnosis/immunology/microbiology/virology
MH  - Adult
MH  - Autopsy
MH  - Brazil
MH  - Central Nervous System/immunology/microbiology/*pathology/virology
MH  - Coinfection
MH  - Diagnosis, Differential
MH  - Fatal Outcome
MH  - HIV Infections/*diagnosis/immunology/pathology/virology
MH  - HIV-1/immunology/isolation & purification/pathogenicity
MH  - Humans
MH  - *Immunocompromised Host
MH  - Male
MH  - Paracoccidioides/immunology/isolation & purification/pathogenicity
MH  - Paracoccidioidomycosis/*diagnosis/immunology/microbiology/pathology
OTO - NOTNLM
OT  - Central nervous system
OT  - Co-infection
OT  - HIV
OT  - Neuro-paracoccidioidomycosis
OT  - Paracoccidioides brasiliensis
OT  - Paracoccidioidomycosis
EDAT- 2017/09/13 06:00
MHDA- 2018/07/22 06:00
CRDT- 2017/09/13 06:00
PHST- 2017/06/27 00:00 [received]
PHST- 2017/08/24 00:00 [accepted]
PHST- 2017/08/04 00:00 [revised]
PHST- 2017/09/13 06:00 [pubmed]
PHST- 2018/07/22 06:00 [medline]
PHST- 2017/09/13 06:00 [entrez]
AID - 10.1007/s13365-017-0577-1 [pii]
AID - 10.1007/s13365-017-0577-1 [doi]
PST - ppublish
SO  - J Neurovirol. 2017 Dec;23(6):913-918. doi: 10.1007/s13365-017-0577-1. Epub 2017 
      Sep 11.