PMID- 28895569
OWN - NLM
STAT- MEDLINE
DCOM- 20181120
LR  - 20230201
IS  - 1740-634X (Electronic)
IS  - 0893-133X (Print)
IS  - 0893-133X (Linking)
VI  - 43
IP  - 3
DP  - 2018 Feb
TI  - The Effects of the Monoamine Stabilizer (-)-OSU6162 on Binge-Like Eating and 
      Cue-Controlled Food-Seeking Behavior in Rats.
PG  - 617-626
LID - 10.1038/npp.2017.215 [doi]
AB  - Binge-eating disorder (BED) is characterized by recurring episodes of excessive 
      consumption of palatable food and an increased sensitivity to food cues. Patients 
      with BED display an addiction-like symptomatology and the dopamine system might 
      be a potential treatment target. The clinically safe monoamine stabilizer 
      (-)-OSU6162 (OSU6162) restores dopaminergic dysfunction in long-term 
      alcohol-drinking rats and shows promise as a novel treatment for alcohol use 
      disorder. Here, the effects of OSU6162 on consummatory (binge-like eating) and 
      appetitive (cue-controlled seeking) behavior motivated by chocolate-flavored 
      sucrose pellets were evaluated in non-food-restricted male Lister Hooded rats. 
      OSU6162 significantly reduced binge-like intake of chocolate-flavored sucrose 
      pellets without affecting prior chow intake. Furthermore, OSU6162 significantly 
      reduced the cue-controlled seeking of chocolate-flavored sucrose pellets under a 
      second-order schedule of reinforcement before, but not after, the delivery and 
      ingestion of reward, indicating a selective effect on incentive motivational 
      processes. In contrast, the dopamine D2/D3 receptor antagonist raclopride reduced 
      the seeking of chocolate-flavored sucrose pellets both pre- and post reward 
      ingestion and also reduced responding under simpler schedules of seeking 
      behavior. The D1/5 receptor antagonist SCH23390 had no effect on instrumental 
      behavior under any reinforcement schedule tested. Finally, local administration 
      of OSU6162 into the nucleus accumbens core, but not dorsolateral striatum, 
      selectively reduced cue-controlled sucrose seeking. In conclusion, the present 
      results show that OSU6162 reduces binge-like eating behavior and attenuates the 
      impact of cues on seeking of palatable food. This indicates that OSU6162 might 
      serve as a novel BED medication.
FAU - Feltmann, Kristin
AU  - Feltmann K
AUID- ORCID: 0000-0002-4928-9111
AD  - Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska 
      Institutet and Stockholm Health Care Services, Stockholm County Council, 
      Stockholm, Sweden.
FAU - Giuliano, Chiara
AU  - Giuliano C
AD  - Department of Psychology and Behavioural and Clinical Neuroscience Institute, 
      University of Cambridge, Cambridge, UK.
FAU - Everitt, Barry J
AU  - Everitt BJ
AD  - Department of Psychology and Behavioural and Clinical Neuroscience Institute, 
      University of Cambridge, Cambridge, UK.
FAU - Steensland, Pia
AU  - Steensland P
AD  - Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska 
      Institutet and Stockholm Health Care Services, Stockholm County Council, 
      Stockholm, Sweden.
FAU - Alsio, Johan
AU  - Alsio J
AD  - Department of Psychology and Behavioural and Clinical Neuroscience Institute, 
      University of Cambridge, Cambridge, UK.
AD  - Department of Neuroscience, Unit of Functional Neurobiology, University of 
      Uppsala, Uppsala, Sweden.
LA  - eng
GR  - G0001354/MRC_/Medical Research Council/United Kingdom
GR  - G1000183/MRC_/Medical Research Council/United Kingdom
GR  - G1002231/MRC_/Medical Research Council/United Kingdom
GR  - MR/N02530X/1/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170912
PL  - England
TA  - Neuropsychopharmacology
JT  - Neuropsychopharmacology : official publication of the American College of 
      Neuropsychopharmacology
JID - 8904907
RN  - 0 (Benzazepines)
RN  - 0 (Dietary Sucrose)
RN  - 0 (Neurotransmitter Agents)
RN  - 0 (Piperidines)
RN  - 0 (SCH 23390)
RN  - 0D21EQAQQA (OSU 6162)
RN  - 430K3SOZ7G (Raclopride)
SB  - IM
MH  - Animals
MH  - Appetitive Behavior/drug effects/physiology
MH  - Benzazepines/pharmacology
MH  - Binge-Eating Disorder/*drug therapy/metabolism
MH  - Bulimia/drug therapy/metabolism
MH  - Conditioning, Operant/drug effects/physiology
MH  - Cues
MH  - Dietary Sucrose
MH  - Dose-Response Relationship, Drug
MH  - Feeding Behavior/*drug effects/physiology
MH  - Male
MH  - Neurotransmitter Agents/*pharmacology
MH  - Nucleus Accumbens/drug effects/metabolism
MH  - Piperidines/*pharmacology
MH  - Raclopride/pharmacology
MH  - Rats
MH  - *Reward
PMC - PMC5770763
EDAT- 2017/09/13 06:00
MHDA- 2018/11/21 06:00
PMCR- 2018/02/01
CRDT- 2017/09/13 06:00
PHST- 2017/06/12 00:00 [received]
PHST- 2017/08/28 00:00 [revised]
PHST- 2017/09/06 00:00 [accepted]
PHST- 2017/09/13 06:00 [pubmed]
PHST- 2018/11/21 06:00 [medline]
PHST- 2017/09/13 06:00 [entrez]
PHST- 2018/02/01 00:00 [pmc-release]
AID - npp2017215 [pii]
AID - 10.1038/npp.2017.215 [doi]
PST - ppublish
SO  - Neuropsychopharmacology. 2018 Feb;43(3):617-626. doi: 10.1038/npp.2017.215. Epub 
      2017 Sep 12.