PMID- 28899213
OWN - NLM
STAT- MEDLINE
DCOM- 20190820
LR  - 20190820
IS  - 0001-5385 (Print)
IS  - 0001-5385 (Linking)
VI  - 73
IP  - 1
DP  - 2018 Feb
TI  - Serum paraoxonase activity in patients with ischaemic and nonischaemic dilated 
      cardiomyopathy.
PG  - 85-90
LID - 10.1080/00015385.2017.1351237 [doi]
AB  - BACKGROUND: This study examined whether the serum PON1 activity is different in 
      patients with ischaemic dilated cardiomyopathy (IDCM) and nonischaemic dilated 
      cardiomyopathy (NDCM) and the relation between the serum PON1 activity and serum 
      pro-BNP levels. METHODS AND RESULTS: In this study, we enrolled 60 patients with 
      left ventricular systolic failure (New York Heart Association [NYHA] class 
      III-IV) and a left ventricular ejection fraction (EF) < 40% as determined by 
      echocardiography and 30 healthy subjects. The patients with systolic heart 
      failure were divided into two groups: patients with IDCM and patients with NDCM. 
      Blood samples were obtained to measure the serum PON1 activity and the serum 
      pro-BNP levels. The median serum PON1 activities were lower among the patients 
      with IDCM or with NDCM compared with the control subjects (p < .001, p = .043, 
      respectively). Compared with the control subjects, the patients with IDCM or with 
      NDCM had higher serum pro-BNP levels (p < .001, p < .001, respectively). The 
      serum PON1 activity was negatively correlated with the serum pro-BNP levels in 
      patients with IDCM (r = -0.548, p < .001). The area under the ROC curve of the 
      serum PON1 activity was 0.798. Using a serum PON1 activity of 201.3 U/L as a 
      cut-off value, the sensitivity was 86.84% and specificity was 66.67% for the 
      diagnosis of IDCM. CONCLUSIONS: In this study, the serum PON1 activity was 
      significantly reduced in the patients with IDCM or with NDCM compared with the 
      control subjects. The serum PON1 activity of the patients with IDCM was 
      negatively correlated with the serum pro-BNP levels.
FAU - Gungoren, Fatih
AU  - Gungoren F
AD  - a Department of Cardiology, Faculty of Medicine , Uludag University , Bursa , 
      Turkey.
FAU - Senturk, Tunay
AU  - Senturk T
AD  - a Department of Cardiology, Faculty of Medicine , Uludag University , Bursa , 
      Turkey.
FAU - Ozturk, Alper
AU  - Ozturk A
AD  - a Department of Cardiology, Faculty of Medicine , Uludag University , Bursa , 
      Turkey.
FAU - Koz, Kerem
AU  - Koz K
AD  - a Department of Cardiology, Faculty of Medicine , Uludag University , Bursa , 
      Turkey.
FAU - Sarandol, Emre
AU  - Sarandol E
AD  - b Department of Clinical Biochemistry, Faculty of Medicine , Uludag University , 
      Bursa , Turkey.
FAU - Yesilbursa, Dilek
AU  - Yesilbursa D
AD  - a Department of Cardiology, Faculty of Medicine , Uludag University , Bursa , 
      Turkey.
FAU - Gullulu, Sumeyye
AU  - Gullulu S
AD  - a Department of Cardiology, Faculty of Medicine , Uludag University , Bursa , 
      Turkey.
FAU - Ozkaya, Guven
AU  - Ozkaya G
AD  - c Department of Bioistatistics, Faculty of Medicine , Uludag University , Bursa , 
      Turkey.
FAU - Aydinlar, Ali
AU  - Aydinlar A
AD  - a Department of Cardiology, Faculty of Medicine , Uludag University , Bursa , 
      Turkey.
LA  - eng
PT  - Journal Article
DEP - 20170912
PL  - England
TA  - Acta Cardiol
JT  - Acta cardiologica
JID - 0370570
RN  - 0 (Biomarkers)
RN  - EC 3.1.8.1 (Aryldialkylphosphatase)
MH  - Aryldialkylphosphatase/*blood
MH  - Biomarkers/blood
MH  - Cardiomyopathy, Dilated/diagnosis/*enzymology/physiopathology
MH  - Disease Progression
MH  - Echocardiography
MH  - Electrocardiography
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Ischemia/diagnosis/*enzymology/physiopathology
MH  - Stroke Volume/physiology
OTO - NOTNLM
OT  - Serum paraoxonase
OT  - heart failure
OT  - ischaemic
OT  - nonischaemic dilated cardiomyopathy
EDAT- 2017/09/14 06:00
MHDA- 2019/08/21 06:00
CRDT- 2017/09/14 06:00
PHST- 2017/09/14 06:00 [pubmed]
PHST- 2019/08/21 06:00 [medline]
PHST- 2017/09/14 06:00 [entrez]
AID - 10.1080/00015385.2017.1351237 [doi]
PST - ppublish
SO  - Acta Cardiol. 2018 Feb;73(1):85-90. doi: 10.1080/00015385.2017.1351237. Epub 2017 
      Sep 12.