PMID- 28899229
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20220408
IS  - 1557-9077 (Electronic)
IS  - 1050-7256 (Print)
IS  - 1050-7256 (Linking)
VI  - 28
IP  - 1
DP  - 2018 Jan
TI  - Thyroid Storm: A Japanese Perspective.
PG  - 32-40
LID - 10.1089/thy.2017.0243 [doi]
AB  - BACKGROUND: Thyroid storm (TS) is life threatening. In the mid-2000s, its 
      incidence was poorly defined, peer-reviewed diagnostic criteria were not 
      available, and management and treatment did not seem to be verified based upon 
      evidence and latest advances in medicine. METHODS: First, diagnostic criteria 
      were developed based on 99 patients in the literature and seven patients in this 
      study. Then, initial and follow-up surveys were conducted from 2004 through 2008, 
      targeting all hospitals in Japan to obtain and verify information on patients who 
      met diagnostic criteria for TS. Based on these data, the diagnostic criteria were 
      revised, and management and treatment guidelines were created. RESULTS: The 
      incidence of TS in hospitalized patients in Japan was estimated to be 0.20 per 
      100,000 per year and 0.22% of all thyrotoxic patients. The mortality rate was 
      10.7%. Multiple organ failure was the most common cause of death, followed by 
      congestive heart failure, respiratory failure, and arrhythmia. In the final 
      diagnostic criteria for TS, the definition of jaundice as serum bilirubin 
      concentration >3 mg/dL was added. Based upon nationwide surveys and the latest 
      information, guidelines for the management and treatment for TS were extensively 
      revised and algorithms were developed. CONCLUSIONS: TS remains a life-threatening 
      disorder, with >10% mortality in Japan. New peer-reviewed diagnostic criteria for 
      TS are presented and its clinical features, prognosis, and incidence are 
      clarified based on nationwide surveys. Furthermore, this information helped to 
      establish detailed guidelines for the management and treatment of TS. A 
      prospective prognostic study to validate the guidelines is eagerly anticipated.
FAU - Akamizu, Takashi
AU  - Akamizu T
AD  - The First Department of Medicine, Wakayama Medical University , Wakayama, Japan .
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20171005
PL  - United States
TA  - Thyroid
JT  - Thyroid : official journal of the American Thyroid Association
JID - 9104317
SB  - IM
MH  - Humans
MH  - Incidence
MH  - Japan/epidemiology
MH  - Prognosis
MH  - Survival Rate
MH  - Thyroid Crisis/*diagnosis/epidemiology/mortality
PMC - PMC5770119
OTO - NOTNLM
OT  - diagnostic criteria
OT  - guideline
OT  - management
OT  - thyroid crisis
OT  - treatment
COIS- The author has nothing to disclose, except for research grants from the Ministry 
      of Health, Labor, and Welfare of Japan.
EDAT- 2017/09/14 06:00
MHDA- 2018/12/12 06:00
PMCR- 2018/01/01
CRDT- 2017/09/14 06:00
PHST- 2017/09/14 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2017/09/14 06:00 [entrez]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.1089/thy.2017.0243 [pii]
AID - 10.1089/thy.2017.0243 [doi]
PST - ppublish
SO  - Thyroid. 2018 Jan;28(1):32-40. doi: 10.1089/thy.2017.0243. Epub 2017 Oct 5.