PMID- 28899642
OWN - NLM
STAT- MEDLINE
DCOM- 20180716
LR  - 20180716
IS  - 1097-6795 (Electronic)
IS  - 0894-7317 (Linking)
VI  - 30
IP  - 11
DP  - 2017 Nov
TI  - Evaluation of Myocardial Function According to Early Diastolic Intraventricular 
      Pressure Difference in Fetuses.
PG  - 1130-1137.e1
LID - S0894-7317(17)30559-X [pii]
LID - 10.1016/j.echo.2017.07.013 [doi]
AB  - BACKGROUND: Intraventricular pressure difference (IVPD), the diastolic suction 
      during early diastole, is known as a useful marker of myocardial diastolic 
      function in adults with different heart diseases, but there are no studies of 
      fetal IVPD. The aim of this study was to determine whether IVPD exists and 
      changes prenatally and whether IVPD correlates with preexisting parameters to 
      evaluate fetal cardiac diastolic function and ventricular dominance. METHODS: 
      Cross-sectional study data (stroke volume, fetal cardiac output, E/A ratio, and 
      myocardial performance index) from 117 healthy fetuses at 17 to 36 weeks of 
      gestation were retrospectively evaluated. The total IVPD was calculated using 
      Euler's equation with color M-mode data. Segmental IVPD was evaluated as apical, 
      mid, and basal IVPDs. RESULTS: The total IVPD in the right ventricle and left 
      ventricle significantly increased in late gestation compared with that in 
      different fetuses studied at midgestation (right and left ventricles, rho = 0.813 
      and rho = 0.895, respectively; P < .001). In both ventricles, the apical IVPD 
      percentage, but not basal or mid IVPD, significantly increased at late gestation 
      compared with that in different fetuses studied at midgestation. Both stroke 
      volumes were correlated with IVPD (right and left ventricles, rho = 0.796 and 
      rho = 0.784, respectively; P < .001). Although myocardial performance index in the 
      left ventricle did not show a significant correlation with IVPD, the E/A ratio 
      had a very weak correlation with IVPD (right ventricle, rho = 0.576, P < .001; left 
      ventricle, rho = 0.338, P < .01). CONCLUSIONS: IVPD has been proved to exist in 
      both ventricles during the fetal stage. The total IVPD increased in late 
      gestation, and the ventricular length increased because of increased apical IVPD 
      in both ventricles. Furthermore, the increase of IVPD in both ventricles was 
      correlated with stroke volume and, accordingly, cardiac output. Left ventricular 
      dominance in IVPD from the fetal stage may offer interesting insight into fetal 
      cardiac development.
CI  - Copyright (c) 2017 American Society of Echocardiography. Published by Elsevier Inc. 
      All rights reserved.
FAU - Yamamoto, Yuka
AU  - Yamamoto Y
AD  - Department of Obstetrics and Gynecology, Juntendo University Faculty of Medicine, 
      Tokyo, Japan.
FAU - Takahashi, Ken
AU  - Takahashi K
AD  - Department of Pediatrics, Juntendo University Faculty of Medicine, Tokyo, Japan. 
      Electronic address: kentaka@juntendo.ac.jp.
FAU - Takemoto, Yo
AU  - Takemoto Y
AD  - Department of Obstetrics and Gynecology, Juntendo University Faculty of Medicine, 
      Tokyo, Japan.
FAU - Kobayashi, Maki
AU  - Kobayashi M
AD  - Department of Pediatrics, Juntendo University Faculty of Medicine, Tokyo, Japan.
FAU - Itatani, Keiichi
AU  - Itatani K
AD  - Department of Cardiovascular Surgery, Kyoto Prefectural University of Medicine, 
      Kyoto, Japan.
FAU - Shimizu, Toshiaki
AU  - Shimizu T
AD  - Department of Pediatrics, Juntendo University Faculty of Medicine, Tokyo, Japan.
FAU - Itakura, Atsuo
AU  - Itakura A
AD  - Department of Obstetrics and Gynecology, Juntendo University Faculty of Medicine, 
      Tokyo, Japan.
FAU - Takeda, Satoru
AU  - Takeda S
AD  - Department of Obstetrics and Gynecology, Juntendo University Faculty of Medicine, 
      Tokyo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20170909
PL  - United States
TA  - J Am Soc Echocardiogr
JT  - Journal of the American Society of Echocardiography : official publication of the 
      American Society of Echocardiography
JID - 8801388
SB  - IM
MH  - Adult
MH  - Cardiac Output/*physiology
MH  - Cross-Sectional Studies
MH  - *Early Diagnosis
MH  - Echocardiography, Doppler, Color/*methods
MH  - Female
MH  - Fetal Heart/diagnostic imaging/*physiology
MH  - Gestational Age
MH  - Heart Defects, Congenital/diagnosis/embryology
MH  - Heart Ventricles/*diagnostic imaging/embryology
MH  - Humans
MH  - Pregnancy
MH  - Reference Values
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Ultrasonography, Prenatal/*methods
MH  - Ventricular Pressure/*physiology
OTO - NOTNLM
OT  - Diastolic function
OT  - Fetal cardiology
OT  - Intraventricular pressure difference
EDAT- 2017/09/14 06:00
MHDA- 2018/07/17 06:00
CRDT- 2017/09/14 06:00
PHST- 2016/10/23 00:00 [received]
PHST- 2017/09/14 06:00 [pubmed]
PHST- 2018/07/17 06:00 [medline]
PHST- 2017/09/14 06:00 [entrez]
AID - S0894-7317(17)30559-X [pii]
AID - 10.1016/j.echo.2017.07.013 [doi]
PST - ppublish
SO  - J Am Soc Echocardiogr. 2017 Nov;30(11):1130-1137.e1. doi: 
      10.1016/j.echo.2017.07.013. Epub 2017 Sep 9.