PMID- 28900083
OWN - NLM
STAT- MEDLINE
DCOM- 20180323
LR  - 20231213
IS  - 0026-8984 (Print)
IS  - 0026-8984 (Linking)
VI  - 51
IP  - 4
DP  - 2017 Jul-Aug
TI  - [The Effects of Chronic Alcoholization on the Expression of Brain-Derived 
      Neurotrophic Factor and Its Receptors in the Brains of Mice Genetically 
      Predisposed to Depressive-Like Behavior].
PG  - 647-655
LID - 10.7868/S002689841704005X [doi]
AB  - Brain-derived neurotropic factor (BDNF) plays an important role in mechanisms of 
      depression. Precursor protein of this factor (proBDNF) can initiate apoptosis in 
      the brain, while the mature form of BDNF is involved in neurogenesis. It is known 
      that chronic alcoholization leads to the activation of apoptotic processes, 
      neurodegeneration, brain injury, and cognitive dysfunction. In this work, we have 
      studied the influence of long-term ethanol exposure on the proBDNF and BDNF 
      protein levels, as well as on the expression of genes that encode these proteins 
      in the brain structures of ASC mice with genetic predisposition to 
      depressive-like behavior and in mice from parental nondepressive CBA strain. It 
      was shown that chronic alcoholization results in a reduction of the BDNF level in 
      the hippocampus and an increase in the amount of TrkB and p75 receptors in the 
      frontal cortex of nondepressive CBA mice. At the same time, the long-term 
      alcoholization of depressive ASC mice results in an increase of the proBDNF level 
      in the frontal cortex and a reduction in the p75 protein level in the 
      hippocampus. It has also been shown that, in depressive ASC mice, proBDNF and 
      BDNF levels are significantly lower in the hippocampus and the frontal cortex 
      compared with nondepressive CBA strain. However, no significant differences in 
      the expression of genes encoding the studied proteins were observed. Thus, 
      changes in the expression patterns of proBDNF, BDNF, and their receptors under 
      the influence of alcoholization in the depressive ASC strain and nondepressive 
      CBA strain mice are different.
FAU - Bazovkina, D V
AU  - Bazovkina DV
AD  - Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, 
      Novosibirsk, 630090 Russia.
FAU - Kondaurova, E M
AU  - Kondaurova EM
AD  - Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, 
      Novosibirsk, 630090 Russia.
FAU - Tsybko, A S
AU  - Tsybko AS
AD  - Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, 
      Novosibirsk, 630090 Russia.
FAU - Kovetskaya, A I
AU  - Kovetskaya AI
AD  - Novosibirsk State University, Novosibirsk, 630090 Russia.
FAU - Ilchibaeva, T V
AU  - Ilchibaeva TV
AD  - Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, 
      Novosibirsk, 630090 Russia.
FAU - Naumenko, V S
AU  - Naumenko VS
AD  - Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, 
      Novosibirsk, 630090 Russia.
AD  - naumenko2002@bionet.nsc.ru.
LA  - rus
PT  - Journal Article
PL  - Russia (Federation)
TA  - Mol Biol (Mosk)
JT  - Molekuliarnaia biologiia
JID - 0105454
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Protein Precursors)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - 0 (Ngfr protein, mouse)
RN  - 0 (brain-derived neurotrophic factor precursor)
RN  - 3K9958V90M (Ethanol)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Alcoholism/complications/*genetics/metabolism/pathology
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*genetics/metabolism
MH  - Depressive Disorder/complications/*genetics/metabolism/pathology
MH  - Disease Models, Animal
MH  - Ethanol/toxicity
MH  - Frontal Lobe/*drug effects/metabolism/pathology
MH  - Gene Expression Regulation
MH  - Genetic Predisposition to Disease
MH  - Hippocampus/*drug effects/metabolism/pathology
MH  - Male
MH  - Mice
MH  - Mice, Inbred CBA
MH  - Mice, Transgenic
MH  - Protein Precursors/genetics/metabolism
MH  - Receptor, trkB/*genetics/metabolism
MH  - Receptors, Nerve Growth Factor/genetics/metabolism
MH  - Signal Transduction
OTO - NOTNLM
OT  - BDNF precursor proBDNF
OT  - TrkB and p75 receptors
OT  - brain-derived neurotrophic factor BDNF
OT  - chronic alcoholization
OT  - hereditary predisposition to depressive-like behavior
OT  - mRNA and protein levels
OT  - mice
EDAT- 2017/09/14 06:00
MHDA- 2018/03/24 06:00
CRDT- 2017/09/14 06:00
PHST- 2016/07/15 00:00 [received]
PHST- 2016/09/29 00:00 [accepted]
PHST- 2017/09/14 06:00 [entrez]
PHST- 2017/09/14 06:00 [pubmed]
PHST- 2018/03/24 06:00 [medline]
AID - 10.7868/S002689841704005X [doi]
PST - ppublish
SO  - Mol Biol (Mosk). 2017 Jul-Aug;51(4):647-655. doi: 10.7868/S002689841704005X.