PMID- 28900681
OWN - NLM
STAT- MEDLINE
DCOM- 20190605
LR  - 20190605
IS  - 0070-217X (Print)
IS  - 0070-217X (Linking)
VI  - 410
DP  - 2017
TI  - Regulatory Dendritic Cells.
PG  - 47-71
LID - 10.1007/82_2017_60 [doi]
AB  - Dendritic cells (DCs) comprise heterogeneous subsets, functionally classified 
      into conventional DCs (cDCs) and plasmacytoid DCs (pDCs). DCs are considered to 
      be essential antigen (Ag)-presenting cells (APCs) that play crucial roles in 
      activation and fine-tuning of innate and adaptive immunity under inflammatory 
      conditions, as well as induction of immune tolerance to maintain immune 
      homeostasis under steady-state conditions. Furthermore, DC functions can be 
      modified and influenced by stimulation with various extrinsic factors, such as 
      ligands for pattern-recognition receptors (PRRs) and cytokines. On the other 
      hand, treatment of DCs with certain immunosuppressive drugs and molecules leads 
      to the generation of tolerogenic DCs that show downregulation of both the major 
      histocompatibility complex (MHC) and costimulatory molecules, and not only show 
      defective T-cell activation, but also possess tolerogenic properties including 
      the induction of anergic T-cells and regulatory T (T(reg)) cells. To develop an 
      effective strategy for Ag-specific intervention of T-cell-mediated immune 
      disorders, we have previously established the modified DCs with moderately high 
      levels of MHC molecules that are defective in the expression of costimulatory 
      molecules that had a greater immunoregulatory property than classical tolerogenic 
      DCs, which we therefore designated as regulatory DCs (DC(reg)). Herein, we 
      integrate the current understanding of the role of DCs in the control of immune 
      responses, and further provide new information of the characteristics of 
      tolerogenic DCs and DC(reg), as well as their regulation of immune responses and 
      disorders.
FAU - Sato, Katsuaki
AU  - Sato K
AD  - Division of Immunology, Department of Infectious Diseases, Faculty of Medicine, 
      University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan. 
      katsuaki_sato@med.miyazaki-u.ac.jp.
AD  - Japan Agency for Medical Research and Development (AMED), 1-7-1 Otemachi, 
      Chiyoda-Ku, Tokyo, 100-0004, Japan. katsuaki_sato@med.miyazaki-u.ac.jp.
FAU - Uto, Tomofumi
AU  - Uto T
AD  - Division of Immunology, Department of Infectious Diseases, Faculty of Medicine, 
      University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.
AD  - Japan Agency for Medical Research and Development (AMED), 1-7-1 Otemachi, 
      Chiyoda-Ku, Tokyo, 100-0004, Japan.
FAU - Fukaya, Tomohiro
AU  - Fukaya T
AD  - Division of Immunology, Department of Infectious Diseases, Faculty of Medicine, 
      University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.
AD  - Japan Agency for Medical Research and Development (AMED), 1-7-1 Otemachi, 
      Chiyoda-Ku, Tokyo, 100-0004, Japan.
FAU - Takagi, Hideaki
AU  - Takagi H
AD  - Division of Immunology, Department of Infectious Diseases, Faculty of Medicine, 
      University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.
AD  - Japan Agency for Medical Research and Development (AMED), 1-7-1 Otemachi, 
      Chiyoda-Ku, Tokyo, 100-0004, Japan.
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Curr Top Microbiol Immunol
JT  - Current topics in microbiology and immunology
JID - 0110513
SB  - IM
MH  - Animals
MH  - *Dendritic Cells
MH  - Humans
MH  - *Immune Tolerance
MH  - T-Lymphocytes, Regulatory
EDAT- 2017/09/14 06:00
MHDA- 2019/06/06 06:00
CRDT- 2017/09/14 06:00
PHST- 2017/09/14 06:00 [pubmed]
PHST- 2019/06/06 06:00 [medline]
PHST- 2017/09/14 06:00 [entrez]
AID - 10.1007/82_2017_60 [doi]
PST - ppublish
SO  - Curr Top Microbiol Immunol. 2017;410:47-71. doi: 10.1007/82_2017_60.