PMID- 28900721
OWN - NLM
STAT- MEDLINE
DCOM- 20190225
LR  - 20190225
IS  - 1863-2661 (Electronic)
IS  - 1863-2653 (Linking)
VI  - 223
IP  - 2
DP  - 2018 Mar
TI  - Effects of PER3 clock gene polymorphisms on aging-related changes of the cerebral 
      cortex.
PG  - 597-607
LID - 10.1007/s00429-017-1513-0 [doi]
AB  - Considerable evidence suggests that circadian rhythmicity is progressively 
      disrupted in senescence. Among clock genes, Period3 (PER3) has been associated 
      with circadian phenotypes, homeostatic regulation of sleep, and cognitive 
      performance in young adults. However, the effects of PER3 genotype on 
      aging-related changes in both cognitive function and cortical integrity remain 
      largely unknown. To shed light into this issue, we have investigated differences 
      in cognitive performance, patterns of cortical thickness, and cortical glucose 
      consumption in normal elderly subjects homozygous carriers of the short 
      (PER3(4/4), n = 32) and long repeat alleles (PER3(5/5), n = 32). Relationships 
      between cognitive performance and cortical thickness/metabolism were further 
      explored for each PER3 genotype. We found that PER3(5/5) carriers had poorer 
      cognitive performance (attention, executive function, semantic memory, and verbal 
      fluency) and lower cortical integrity (structural and functional) than PER3(4/4). 
      PER3(5/5) further showed thinning of temporo-parietal areas, and reductions of 
      glucose consumption in fronto-temporo-parietal regions bilaterally. Moreover, 
      PER3(5/5) subjects exhibited significant correlations between decreased glucose 
      metabolism in fronto-parietal regions and poorer cognitive flexibility, though 
      only correlations with lower glucose consumption of the supramarginal gyrus 
      distinguished PER3(5/5) from PER3(4/4) groups. Overall, these findings enhance 
      our understanding on the gene-brain interaction in aging, and may have further 
      implications for the detection of subclinical cognitive decline associated with 
      PER3 genotypes in late life.
FAU - Dewandre, Delphine
AU  - Dewandre D
AD  - Laboratory of Functional Neuroscience, Spanish Network of Excellence for Research 
      on Neurodegenerative Diseases (CIBERNED), Pablo de Olavide University, Ctra. de 
      Utrera Km 1, 41013, Seville, Spain.
FAU - Atienza, Mercedes
AU  - Atienza M
AD  - Laboratory of Functional Neuroscience, Spanish Network of Excellence for Research 
      on Neurodegenerative Diseases (CIBERNED), Pablo de Olavide University, Ctra. de 
      Utrera Km 1, 41013, Seville, Spain.
FAU - Sanchez-Espinosa, Mayely P
AU  - Sanchez-Espinosa MP
AD  - Laboratory of Functional Neuroscience, Spanish Network of Excellence for Research 
      on Neurodegenerative Diseases (CIBERNED), Pablo de Olavide University, Ctra. de 
      Utrera Km 1, 41013, Seville, Spain.
FAU - Cantero, Jose L
AU  - Cantero JL
AD  - Laboratory of Functional Neuroscience, Spanish Network of Excellence for Research 
      on Neurodegenerative Diseases (CIBERNED), Pablo de Olavide University, Ctra. de 
      Utrera Km 1, 41013, Seville, Spain. jlcanlor@upo.es.
LA  - eng
GR  - SAF2011-25463/Spanish Ministry of Economy and Competitiveness/
GR  - PSI2014-55747-R/Spanish Ministry of Economy and Competitiveness/
GR  - P12-CTS-2327/Regional Ministry of Innovation, Science and Enterprise, Junta de 
      Andalucia/
GR  - CB06/05/1111/CIBERNED/
GR  - 2017/Spanish Sleep Society/
PT  - Journal Article
DEP - 20170912
PL  - Germany
TA  - Brain Struct Funct
JT  - Brain structure & function
JID - 101282001
RN  - 0 (PER3 protein, human)
RN  - 0 (Period Circadian Proteins)
SB  - IM
MH  - Aged
MH  - Aging/*genetics
MH  - Cerebral Cortex/diagnostic imaging/metabolism/*physiology
MH  - Circadian Rhythm/genetics
MH  - Cognition/*physiology
MH  - Correlation of Data
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Period Circadian Proteins/*genetics
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Positron-Emission Tomography
MH  - Statistics, Nonparametric
OTO - NOTNLM
OT  - Aging
OT  - Cognitive function
OT  - Cortical metabolism
OT  - Cortical thickness
OT  - PER3
OT  - PET
EDAT- 2017/09/14 06:00
MHDA- 2019/02/26 06:00
CRDT- 2017/09/14 06:00
PHST- 2016/12/17 00:00 [received]
PHST- 2017/09/07 00:00 [accepted]
PHST- 2017/09/14 06:00 [pubmed]
PHST- 2019/02/26 06:00 [medline]
PHST- 2017/09/14 06:00 [entrez]
AID - 10.1007/s00429-017-1513-0 [pii]
AID - 10.1007/s00429-017-1513-0 [doi]
PST - ppublish
SO  - Brain Struct Funct. 2018 Mar;223(2):597-607. doi: 10.1007/s00429-017-1513-0. Epub 
      2017 Sep 12.