PMID- 28901742
OWN - NLM
STAT- MEDLINE
DCOM- 20190111
LR  - 20190111
IS  - 1944-8252 (Electronic)
IS  - 1944-8244 (Linking)
VI  - 9
IP  - 39
DP  - 2017 Oct 4
TI  - Surface Modification of Poly(dimethylsiloxane) with Polydopamine and Hyaluronic 
      Acid To Enhance Hemocompatibility for Potential Applications in Medical Implants 
      or Devices.
PG  - 33632-33644
LID - 10.1021/acsami.7b10260 [doi]
AB  - Poly(dimethylsiloxane) (PDMS) has been widely utilized in micro-electromechanical 
      systems (MEMS) and implantable devices. To improve the hemocompatibility of a 
      PDMS-based implant, a facile technique was developed by modifying PDMS with a 
      hyaluronic acid (HA) and polydopamine (PDA) composite (HA/PDA). Under appropriate 
      ratio of HA to PDA, platelet adhesion and activation were considerably reduced on 
      modified PDMS substrates, indicating an enhanced hemocompatibility compared to 
      native PDMS or those coated with HA or PDA solely. HA/PDA coating also posed 
      minimal cytotoxicity on the adhesion and proliferation of endothelial cells 
      (HUVECs). The anti-inflammation effect of the modified PDMS surface was 
      characterized based on the expression of critical cytokines in adherent 
      macrophages. This study revealed that the hemocompatibility, cytotoxicity, and 
      anti-inflammation properties could be tailored conveniently by adjusting the 
      ratio of HA and PDA composite on the modified PDMS surface, which has an 
      exceptional potential as the core or packaging material for constructing 
      implantable devices in biomedical applications.
FAU - Xue, Peng
AU  - Xue P
AD  - Institute for Clean Energy and Advanced Materials, Faculty of Materials and 
      Energy, Southwest University , Chongqing 400715, China.
AD  - Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and 
      Devices , Chongqing 400715, China.
FAU - Li, Qian
AU  - Li Q
AD  - Institute for Clean Energy and Advanced Materials, Faculty of Materials and 
      Energy, Southwest University , Chongqing 400715, China.
AD  - Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and 
      Devices , Chongqing 400715, China.
FAU - Li, Yuan
AU  - Li Y
AD  - Yongchuan Hospital, Chongqing Medical University , Chongqing 402160, China.
FAU - Sun, Lihong
AU  - Sun L
AD  - Institute for Clean Energy and Advanced Materials, Faculty of Materials and 
      Energy, Southwest University , Chongqing 400715, China.
AD  - Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and 
      Devices , Chongqing 400715, China.
FAU - Zhang, Lei
AU  - Zhang L
AD  - State Key Laboratory of Silkworm Genome Biology, Southwest University , Chongqing 
      400716, China.
FAU - Xu, Zhigang
AU  - Xu Z
AUID- ORCID: 0000-0003-1805-5061
AD  - Institute for Clean Energy and Advanced Materials, Faculty of Materials and 
      Energy, Southwest University , Chongqing 400715, China.
AD  - Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and 
      Devices , Chongqing 400715, China.
FAU - Kang, Yuejun
AU  - Kang Y
AUID- ORCID: 0000-0002-1021-0349
AD  - Institute for Clean Energy and Advanced Materials, Faculty of Materials and 
      Energy, Southwest University , Chongqing 400715, China.
AD  - Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and 
      Devices , Chongqing 400715, China.
LA  - eng
PT  - Journal Article
DEP - 20170925
PL  - United States
TA  - ACS Appl Mater Interfaces
JT  - ACS applied materials & interfaces
JID - 101504991
RN  - 0 (Dimethylpolysiloxanes)
RN  - 0 (Indoles)
RN  - 0 (Polymers)
RN  - 0 (polydopamine)
RN  - 9004-61-9 (Hyaluronic Acid)
SB  - IM
MH  - Dimethylpolysiloxanes/*chemistry
MH  - Hyaluronic Acid
MH  - Indoles
MH  - Polymers
MH  - Prostheses and Implants
MH  - Surface Properties
OTO - NOTNLM
OT  - anti-inflammation
OT  - hemocompatibility
OT  - hyaluronic acid
OT  - poly(dimethylsiloxane)
OT  - polydopamine
OT  - surface functionalization
EDAT- 2017/09/14 06:00
MHDA- 2019/01/12 06:00
CRDT- 2017/09/14 06:00
PHST- 2017/09/14 06:00 [pubmed]
PHST- 2019/01/12 06:00 [medline]
PHST- 2017/09/14 06:00 [entrez]
AID - 10.1021/acsami.7b10260 [doi]
PST - ppublish
SO  - ACS Appl Mater Interfaces. 2017 Oct 4;9(39):33632-33644. doi: 
      10.1021/acsami.7b10260. Epub 2017 Sep 25.