PMID- 28903047
OWN - NLM
STAT- MEDLINE
DCOM- 20180514
LR  - 20180514
IS  - 2211-1247 (Electronic)
VI  - 20
IP  - 11
DP  - 2017 Sep 12
TI  - Caloric Restriction Promotes Structural and Metabolic Changes in the Skin.
PG  - 2678-2692
LID - S2211-1247(17)31177-4 [pii]
LID - 10.1016/j.celrep.2017.08.052 [doi]
AB  - Caloric restriction (CR) is the most effective intervention known to enhance 
      lifespan, but its effect on the skin is poorly understood. Here, we show that CR 
      mice display fur coat remodeling associated with an expansion of the hair 
      follicle stem cell (HFSC) pool. We also find that the dermal adipocyte depot 
      (dWAT) is underdeveloped in CR animals. The dermal/vennule annulus vasculature is 
      enlarged, and a vascular endothelial growth factor (VEGF) switch and metabolic 
      reprogramming in both the dermis and the epidermis are observed. When the fur 
      coat is removed, CR mice display increased energy expenditure associated with 
      lean weight loss and locomotion impairment. Our findings indicate that CR 
      promotes extensive skin and fur remodeling. These changes are necessary for 
      thermal homeostasis and metabolic fitness under conditions of limited energy 
      intake, suggesting a potential adaptive mechanism.
CI  - Copyright (c) 2017 The Author(s). Published by Elsevier Inc. All rights reserved.
FAU - Forni, Maria Fernanda
AU  - Forni MF
AD  - Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Av. 
      Prof. Lineu Prestes, 748, 05508-000 Sao Paulo, Brazil.
FAU - Peloggia, Julia
AU  - Peloggia J
AD  - Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Av. 
      Prof. Lineu Prestes, 748, 05508-000 Sao Paulo, Brazil.
FAU - Braga, Tarcio T
AU  - Braga TT
AD  - Instituto de Ciencias Biomedicas, Universidade de Sao Paulo. Av. Prof. Lineu 
      Prestes, 1730, 05508-900 Sao Paulo, Brazil.
FAU - Chinchilla, Jesus Eduardo Ortega
AU  - Chinchilla JEO
AD  - Departamento de Fisiologia, Instituto de Biologia, Universidade de Sao Paulo, R. 
      do Matao, 321, 05508-090 Sao Paulo, Brazil.
FAU - Shinohara, Jorge
AU  - Shinohara J
AD  - Laboratorio de Quimica Supramolecular e Nanotecnologia - LQSN, Instituto de 
      Quimica, Universidade de Sao Paulo, Av. Prof. Lineu Prestes, 748, 05508-000 Sao 
      Paulo, Brazil.
FAU - Navas, Carlos Arturo
AU  - Navas CA
AD  - Departamento de Fisiologia, Instituto de Biologia, Universidade de Sao Paulo, R. 
      do Matao, 321, 05508-090 Sao Paulo, Brazil.
FAU - Camara, Niels Olsen Saraiva
AU  - Camara NOS
AD  - Instituto de Ciencias Biomedicas, Universidade de Sao Paulo. Av. Prof. Lineu 
      Prestes, 1730, 05508-900 Sao Paulo, Brazil.
FAU - Kowaltowski, Alicia J
AU  - Kowaltowski AJ
AD  - Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Av. 
      Prof. Lineu Prestes, 748, 05508-000 Sao Paulo, Brazil. Electronic address: 
      alicia@iq.usp.br.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cell Rep
JT  - Cell reports
JID - 101573691
SB  - IM
MH  - Adipose Tissue, White/anatomy & histology
MH  - Animals
MH  - Body Temperature Regulation
MH  - Body Weight
MH  - *Caloric Restriction
MH  - Dermis/anatomy & histology
MH  - Epidermis/anatomy & histology
MH  - Hair Follicle/cytology/growth & development
MH  - Locomotion
MH  - Mice
MH  - Oxidation-Reduction
MH  - Skin/*anatomy & histology/blood supply/*metabolism/ultrastructure
MH  - Stem Cells/cytology
MH  - Time Factors
OTO - NOTNLM
OT  - aging
OT  - calorie restriction
OT  - dietary restriction
OT  - fur
OT  - metabolism
OT  - mitochondria
OT  - skin stem cells
OT  - thermoregulation
EDAT- 2017/09/14 06:00
MHDA- 2018/05/15 06:00
CRDT- 2017/09/14 06:00
PHST- 2016/08/19 00:00 [received]
PHST- 2017/06/09 00:00 [revised]
PHST- 2017/08/16 00:00 [accepted]
PHST- 2017/09/14 06:00 [entrez]
PHST- 2017/09/14 06:00 [pubmed]
PHST- 2018/05/15 06:00 [medline]
AID - S2211-1247(17)31177-4 [pii]
AID - 10.1016/j.celrep.2017.08.052 [doi]
PST - ppublish
SO  - Cell Rep. 2017 Sep 12;20(11):2678-2692. doi: 10.1016/j.celrep.2017.08.052.