PMID- 28904917
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240326
IS  - 2229-516X (Print)
IS  - 2248-9606 (Electronic)
IS  - 2229-516X (Linking)
VI  - 7
IP  - 3
DP  - 2017 Jul-Sep
TI  - Evaluation of Leptin as a Marker of Insulin Resistance in Type 2 Diabetes 
      Mellitus.
PG  - 176-180
LID - 10.4103/ijabmr.IJABMR_278_16 [doi]
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) is a leading cause of mortality and 
      morbidity worldwide, whose incidence is rapidly increasing in India. T2DM is 
      caused by varying degrees of insulin resistance (IR) and relative insulin 
      deficiency. Leptin, an adipokine with the primary function of regulating energy 
      balance, is found to mediate insulin secretion and sensitivity in peripheral 
      tissues. Hence, we aimed to determine the role of leptin in the development of IR 
      in newly diagnosed T2DM patients. AIM: This study aims to compare the leptin 
      levels and homeostatic model assessment-IR (HOMA-IR) levels in the study 
      population. MATERIAL AND METHODS: The study included a total of sixty patients 
      newly diagnosed with T2DM. Their fasting blood samples were collected to estimate 
      the glucose, insulin, and leptin levels. IR was calculated using HOMA-IR formula. 
      Statistical analysis was done by Pearson's correlation, Spearman's correlation, 
      and One-sample Wilcoxon Signed Rank test. RESULTS: Leptin and HOMA-IR levels were 
      significantly high in T2DM patients (P < 0.001) when compared with reference 
      values. Body mass index showed a significant positive correlations with insulin 
      (r = 0.40, P < 0.01), HOMA-IR (r = 0.37, P < 0.01), and leptin levels (r = 0.90, 
      P < 0.01). Leptin levels showed significant positive correlations with plasma 
      insulin (r = 0.35, P < 0.01) and HOMA-IR levels (r = 0.31, P < 0.05). The 
      correlation between leptin and HOMA-IR levels was more pronounced and significant 
      among the obese T2DM subjects (r = 0.82, P = 0.01). CONCLUSION: Hyperleptinemia 
      reflecting leptin resistance plays an important role in the development of IR in 
      obeseT2DM patients, making leptin a possible biomarker for the same.
FAU - Moonishaa, Thiyagarajan Manjuladevi
AU  - Moonishaa TM
AD  - Department of Biochemistry, Chennai Medical College Hospital and Research Centre, 
      The Tamil Nadu Dr. M. G. R. Medical University, Trichy, Tamil Nadu, India.
FAU - Nanda, Sunil Kumar
AU  - Nanda SK
AD  - Department of Biochemistry, Pondicherry Institute of Medical Sciences, 
      Pondicherry University, Puducherry, India.
FAU - Shamraj, Muthukrishnan
AU  - Shamraj M
AD  - Department of Biochemistry, Pondicherry Institute of Medical Sciences, 
      Pondicherry University, Puducherry, India.
FAU - Sivaa, Rajendran
AU  - Sivaa R
AD  - Department of Biochemistry, Pondicherry Institute of Medical Sciences, 
      Pondicherry University, Puducherry, India.
FAU - Sivakumar, Periyasamy
AU  - Sivakumar P
AD  - Department of General Medicine, Chennai Medical College Hospital and Research 
      Centre, The Tamil Nadu Dr. M. G. R. Medical University, Trichy, Tamil Nadu, 
      India.
FAU - Ravichandran, Kandasamy
AU  - Ravichandran K
AD  - Department of Biostatistics, Pondicherry Institute of Medical Sciences, 
      Pondicherry University, Puducherry, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Int J Appl Basic Med Res
JT  - International journal of applied & basic medical research
JID - 101579831
PMC - PMC5590380
OTO - NOTNLM
OT  - Homeostatic model assessment-insulin resistance
OT  - insulin resistance
OT  - leptin
OT  - type 2 diabetes mellitus
COIS- There are no conflicts of interest.
EDAT- 2017/09/15 06:00
MHDA- 2017/09/15 06:01
PMCR- 2017/07/01
CRDT- 2017/09/15 06:00
PHST- 2017/09/15 06:00 [entrez]
PHST- 2017/09/15 06:00 [pubmed]
PHST- 2017/09/15 06:01 [medline]
PHST- 2017/07/01 00:00 [pmc-release]
AID - IJABMR-7-176 [pii]
AID - 10.4103/ijabmr.IJABMR_278_16 [doi]
PST - ppublish
SO  - Int J Appl Basic Med Res. 2017 Jul-Sep;7(3):176-180. doi: 
      10.4103/ijabmr.IJABMR_278_16.