PMID- 28906578
OWN - NLM
STAT- MEDLINE
DCOM- 20181127
LR  - 20181127
IS  - 1468-1331 (Electronic)
IS  - 1351-5101 (Linking)
VI  - 25
IP  - 1
DP  - 2018 Jan
TI  - Ultra-early hematoma growth in antithrombotic pretreated patients with 
      intracerebral hemorrhage.
PG  - 83-89
LID - 10.1111/ene.13458 [doi]
AB  - BACKGROUND AND PURPOSE: Patients with acute intracerebral hemorrhage (ICH) 
      pretreated with antithrombotic drugs may have increased early hematoma growth, 
      which would increase mortality risk. The effect of antiplatelet (AP) and vitamin 
      K antagonist (VKA) pretreatment on ultra-early hematoma growth (uHG) and its 
      relationship with mortality in patients with acute supratentorial ICH was 
      analyzed. METHODS: This is an observational retrospective study of a prospective 
      register of 197 ICH patients with first computed tomography (CT) scan taken <6 h 
      from ICH symptom onset. ICH volume was calculated by the ABC/2 formula and uHG by 
      the baseline ICH volume/onset-to-CT time (ml/h) formula. The uHG analysis took 
      into account the patient's pretreatment (none, AP or VKA) and the relationship 
      between uHG and very-early (first 24 h) and 3-month mortality. RESULTS: In the 
      pretreatment group, 50 (25.4%) patients were treated with AP and 37 (18.8%) with 
      VKA. The median (interquartile range 25-75) uHG was 19.7 ml/h (2.9-44.8) for AP 
      pretreated patients, 16.2 ml/h (5.1-42.5) for VKA pretreated patients and 8.4 
      ml/h (2.4-21.8) for non-pretreated patients, P = 0.019. The uHG was higher in 
      patients with very-early [42.1 ml/h (20.1-79.6)] and total 3-month mortality 
      [28.0 ml/h (15.8-52.5)] compared with survivors [3.9 ml/h (1.5-10.4)], P < 
      0.0001. Adjusted by ICH severity and previous functional status, uHG was an 
      independent factor related to very-early (P = 0.028) and total 3-month mortality 
      (P = 0.014). CONCLUSIONS: Patients pretreated with antithrombotics have much 
      higher uHG, which would explain the increased mortality in these patients 
      compared to untreated patients.
CI  - (c) 2017 EAN.
FAU - Roquer, J
AU  - Roquer J
AUID- ORCID: 0000-0001-5992-2606
AD  - Neurology Department, IMIM-Hospital del Mar, Barcelona, Spain.
AD  - Departament de Medicina, Universitat Autonoma de Barcelona, Barcelona, Spain.
FAU - Vivanco-Hidalgo, R M
AU  - Vivanco-Hidalgo RM
AD  - Neurology Department, IMIM-Hospital del Mar, Barcelona, Spain.
FAU - Capellades, J
AU  - Capellades J
AD  - Neuroradiology Unit Radiology Department, IMIM-Hospital del Mar, Barcelona, 
      Spain.
FAU - Ois, A
AU  - Ois A
AD  - Neurology Department, IMIM-Hospital del Mar, Barcelona, Spain.
AD  - Departament de Medicina, Universitat Autonoma de Barcelona, Barcelona, Spain.
FAU - Cuadrado-Godia, E
AU  - Cuadrado-Godia E
AD  - Neurology Department, IMIM-Hospital del Mar, Barcelona, Spain.
AD  - DCEXS, Universitat Pompeu Fabra, Barcelona, Spain.
FAU - Giralt-Steinhauer, E
AU  - Giralt-Steinhauer E
AD  - Neurology Department, IMIM-Hospital del Mar, Barcelona, Spain.
FAU - Soriano-Tarraga, C
AU  - Soriano-Tarraga C
AD  - Neurology Department, IMIM-Hospital del Mar, Barcelona, Spain.
FAU - Mola-Caminal, M
AU  - Mola-Caminal M
AD  - Neurology Department, IMIM-Hospital del Mar, Barcelona, Spain.
FAU - Serra-Martinez, M
AU  - Serra-Martinez M
AD  - Neurology Department, IMIM-Hospital del Mar, Barcelona, Spain.
FAU - Avellaneda-Gomez, C
AU  - Avellaneda-Gomez C
AD  - Neurology Department, IMIM-Hospital del Mar, Barcelona, Spain.
FAU - Jimenez-Conde, J
AU  - Jimenez-Conde J
AD  - Neurology Department, IMIM-Hospital del Mar, Barcelona, Spain.
AD  - Departament de Medicina, Universitat Autonoma de Barcelona, Barcelona, Spain.
FAU - Rodriguez-Campello, A
AU  - Rodriguez-Campello A
AD  - Neurology Department, IMIM-Hospital del Mar, Barcelona, Spain.
AD  - Departament de Medicina, Universitat Autonoma de Barcelona, Barcelona, Spain.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20171016
PL  - England
TA  - Eur J Neurol
JT  - European journal of neurology
JID - 9506311
RN  - 0 (Anticoagulants)
RN  - 0 (Antifibrinolytic Agents)
RN  - 0 (Platelet Aggregation Inhibitors)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Anticoagulants/pharmacology/*therapeutic use
MH  - Antifibrinolytic Agents/pharmacology/*therapeutic use
MH  - Brain/*diagnostic imaging/drug effects
MH  - Cerebral Hemorrhage/*diagnostic imaging/mortality
MH  - Female
MH  - Hematoma/*diagnostic imaging/mortality
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Platelet Aggregation Inhibitors/pharmacology/*therapeutic use
MH  - Prospective Studies
MH  - Retrospective Studies
MH  - Tomography, X-Ray Computed
OTO - NOTNLM
OT  - anticoagulant drugs
OT  - antiplatelet agents
OT  - cerebral hemorrhage
OT  - mortality
OT  - prognosis
EDAT- 2017/09/15 06:00
MHDA- 2018/11/28 06:00
CRDT- 2017/09/15 06:00
PHST- 2017/03/31 00:00 [received]
PHST- 2017/08/08 00:00 [accepted]
PHST- 2017/09/15 06:00 [pubmed]
PHST- 2018/11/28 06:00 [medline]
PHST- 2017/09/15 06:00 [entrez]
AID - 10.1111/ene.13458 [doi]
PST - ppublish
SO  - Eur J Neurol. 2018 Jan;25(1):83-89. doi: 10.1111/ene.13458. Epub 2017 Oct 16.